stress and pain Flashcards

1
Q

what are the differences between slow and fast pain?

A

fast is A gamma fiber, sharp/pricking, high threshold, mechano and thermoreceptor, somatic sensations, withdrawal, discriminative
slow is C fibers, dull/burning/aching, high and low threshold, emotional, qualitatively complex

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2
Q

how do the somatosensory, cingulate and insular cortices, and PAG participate in the processing of pain?

A

X

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3
Q

What are the defense responses produced by the PAG?

A

X

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4
Q

Describe the descending control of pain: nuclei, paths, neurotransmitters, actions in the dorsal horn, role of opioids.

A

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5
Q

What are the distinguishing characteristics of acute, inflammatory and neuropathic pain?

A

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6
Q

What is the axon reflex?

A

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7
Q

What is meant by peripheral and central sensitization? What are the mechanisms of each?

A

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8
Q

What is the difference between hyperalgesia and allodynia?

A

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9
Q

What are the roles of the vmPFC and dlPFC in pain modulation? What

A

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10
Q

What happens to pain sensitivity with degeneration of the dlPFC?

A

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11
Q

In migraine, what is cortical spreading depression and how does it impact pain afferents and dural blood vessels?

A

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12
Q

What is the peripheral sensitization in this (MIGRAINE) case?

A

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13
Q

What are the major characteristics of the sympathoadrenal stress response system in terms of: LC and its projections, impact on the PFC and peripheral structures?

A

x

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14
Q

What are the structures that form the HPA axis?

A

x

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15
Q

What hormones do they (HPA axis) release and where do those hormones act?

A

x

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16
Q

Where are CRH neurons located?

A

x

17
Q

What impact does changing their number or activity have on HPA activity?

A

x

18
Q

What are the permissive/suppressive actions of cortisol on metabolism and inflammation?

A

x

19
Q

How does cortisol feedback impact CRH and ACTH release?

A

x

20
Q

What is cortisol resistance in the HPA axis and what impact does it have on cortisol release?

A

x

21
Q

What are the general functions of cortisol feedback in the hippocampus?

A

x

22
Q

Compare the 3 phases brain stress responses and how MR and GR receptors are involved.

A

x

23
Q

How does cortisol feedback affect the prefrontal cortex and amygdala?

A

x

24
Q

What are the major characteristics of hypercortisolism as seen in chronic stress?

A

x

25
Q

What role does cortisol resistance have in this?

A

x

26
Q

What impact does hypercortisolism have on circadian cortisol fluctuations, metabolism, limbic system (amygdla, hippocampus, PFC), development of CRH system, inflammatory actions?

A

x

27
Q

Compare the causes and manifestations of Addison’s and Cushing’s disease.

A

x