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dönem3komite1 > streptogramins > Flashcards

streptogramins Flashcards

1
Q

Quinupristin-dalfopristin is administered ….

A

intravenously

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2
Q

Streptogramins are…

A

Quinupristin-dalfopristin

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3
Q

Streptogramins, mechanism of action:

A

inhibit protein synthesis

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4
Q

Quinupristin-dalfopristin is rapidly bactericidal for most susceptible organisms except ……

A

Enterococcus faecium

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5
Q

Streptogramin Resistance is due to …

A

modification of the quinupristin binding site,
enzymatic inactivation of dalfopristin,
efflux.

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6
Q

Elimination of Streptogramins is principally by the ….route.

A

fecal

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7
Q

Dose adjustment is ………… for renal failure, peritoneal dialysis or hemodialysis for Streptogramins

A

not necessary

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8
Q

Quinupristin and dalfopristin significantly …..CYP3A4

A

inhibit

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9
Q

The principal toxicities of Streptogramins are ……

A

Infusion related events, such as pain at the infusion site, and an arthralgia-myalgia syndrome

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