Stomach Flashcards
What cells give rise to gastric neuroendocrine tumors
Enterochromaffin like cells
What is the most common type of gNET in stomach most associated with
Autoimmune chronic gastritis
Which cell is targeted by antibodies in autoimmune chronic gastritis
Gastric parietal cell
What is a consequence of achlorhydria
Increased gastrin production and ECL hyperplasia
Is intrinsic factor increased or decreased in autoimmune chronic gastritis
Decreased
What vitamin is absorbed with a co-factor
Vitamin B12
Type II lesions are known as what syndrome
Zollinger Ellison
What condition is associated with ZE
MEN-1, dx serum sequencing MEN1 gene16
On biopsy, which condition is associated with absent parietal cells and neuroendocrine cell hyperplasia with high pH
Type I gNET
On biopsy, which condition is associated with normal or hypertrophic mucosa, and low pH
Type 2 gNET
What nuclear medicine study can be done to localize Type 2 NETs?
Octreotide
What gNET commonly presents as a single gastric lesion
Type 3 gNET
What modalities are recommended for staging type I and II gNETs >2cm, and all type III lesions?
CT scan,> MRI, ocreotide, scitinigraphy and PET-CT
Which gNET should be managed by subtotal gastrectomy and lymphadenectomy
Type III
