STIs Flashcards

1
Q

3 basic microbial testing for STIs

A
1. NAATs 
nucleic acid amplification testing 
rely on detection of DNA 
used for chlamydia and n.gonnorhoea 
PCR can also be used for herpes 
  1. microscopy, culture and sensitivity
    for gonorrhoea, candida, bacterial vaginosis, trichomonas vaginalis
  2. blood tests
    syphilis, HIV, hepatitis
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2
Q

chlamydia symptoms

A

Female

post-coital bleeding, abdo tender, pelvic tender, infertility, Reiter’s syndrome, proctitis, pharyngitis, perihepatitis

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3
Q

which serotypes of chlamydia give lymphogrnauloma venereum cancer

A

L1, L2, L3

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4
Q

complications of chlamydia

A

PID (1-30%)
sexually acquired arthritis (urethritis, arthritis, conjunctivitis = reiter’s)
epididymo-orchitis
peri-hepatitis

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5
Q

manifestations of neonatal chlamydia

A

conjunctivitis 5-12 days after births

pneumonia 1-3 months

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6
Q

chlamydia treatment

A

doxycycline 100mg for 7/7
avoid sexual contact for duration of treatment
partner notification

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7
Q

how does lymphogranuloma venerum present

A

solitary genital lesion
proctitis
lymphadenopathy

TREAT doxycycline

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8
Q

neonatal gonorrhea

A

opthalmia neonatorum - blindness :(

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9
Q

treatment for gonorrhoea

A

ceftriaxone 1g IM !!!!
ciprofloxacin 500mg orally

then test of cure NAAT if asymptomatic

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10
Q

when do you have to notify partner if gonorrhoea?
symptomatic male:
asymptomatic/other sites

A

all partners within preceding 2 weeks (or last partner if over 2 weeks ago)
asymptomatic/other sites: preceding 3 months

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11
Q

what’s the most common cause of abnormal vaginal discharge in women of child bearing age?

A

bacterial vaginosis
overgrowth of lactobacilli
offensive fishy odour withour itch/irritation

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12
Q

treating bacterial vaginosis

A

metronidazole

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13
Q

presentation of thrush

A

itch
vulval pain
superficial dyspareunia
curd like white vaginal discharge

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14
Q

treatment of thrush

A

topical clotrimazole

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15
Q

primary syphilis

A

hard genital or oral ulcer called a CHANCRE at site of infection for 3 weeks

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16
Q

secondary syphilis

A

red maculopapular rash anywhere plus pale moist papules in urogenital region and mouth (lies latent for 3-30 years)

17
Q

tertiary syphilis

A

degeneration of Ns
aneurysms
granulomatous lesions in liver, skin, bones (gummas) in 40% patients

18
Q

when does congenital syphilis get passed to child?

A

placental transfer after 10-15 weeks

can cause death or spontaneous abortion of foetus
survivors -> secondary syphilis symptoms

19
Q

what does HPV cause

A

hyperplastic epithelial lesions

20
Q

important HPV types

A

6, 11 = genital warts

16, 18 = cancer

21
Q

treatment for 6,11 HPV genital warts

A

podophyllum (cream)
cryo
laser
surgery

22
Q

HPV vaccine based on what?

Two types

A

VLP1 a major capsid protein

Cervarix (bivalent)
Gardasil (quadrivalent)

23
Q

Herpes Simplex Virus Type 1

A

affects oral region and causes cold sores

24
Q

Herpes Simplex Virus Type 2

A

genital infection (penis, anus, vagina)

25
Q

Genital herpes primary infection

A

febrile flu-like (5-7 days)
tingling neuropathic pain in genital area/buttocks/legs
extensive bilateral crops of PAINFUL blisters
tender inguinal lymph nodes
local oedema
dysuria
vaginal/urethral discharge

26
Q

treatment of primary genital herpes

A

saline bathing
local anaesthetics
aciclovir - if within 5 days of start of episode

27
Q

what happens to HSV following primary infection

A

latent in local sensory ganglia

28
Q

PrEP

A

pre-exposure prophylaxis for HIV

29
Q

treatment for herpes simplex virus type 2

A

genital warts

ACLICLOVIR

30
Q

solitary painless ulcer

A

primary syphilis

a CHANCRE

31
Q

symptoms of PCOS

A

hirsutism
acne
male pattern balding (receding hairline)

32
Q

three signs on examination suggestive of male infertility

A

variocele
undescended testes
hypogonadism
torsion

33
Q

which three treatments of PCOS can increase chance of conception

A

weight loss
metformin
clomifene