Stimulants Of Hepcidin

Question 1

Stimulants of Hepcidin

Answer 1

1. Lipopolysaccharides (LPS)
2. Inflammatory mediators (IL-6)
3. Increased ferrous iron in the blood (Fe2+)
4. Hemochromatosis Gene (HFE Gene)

Question 2

Among the 4 stimulants, what is the major regulator?

Answer 2

HFE Gene

Question 3

What happens in GFE gen mutation?

Answer 3

There will be less hepcidin and there will be no inhibitor of Ferroportin
⚡️ Continuous delivery of iron into the blood which is called HEMATOCHROMATOSIS