Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharmacology 2nd Sem Finals > Steroids > Flashcards

Steroids Flashcards

1
Q

Most important mineralocorticoid

A

Aldosterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Major adrenal androgen

A

DHEA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Major endogenous precursor of estrogen in women after menopause

A

Adrenal androgen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Glucocorticoid synthesized from

A

Cholesterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Glucorticoids rate of secretion follows __________ governed by pulses of _______

A

Circadian rhythm

ACTH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Glucorticoids in plasma bound to circulating

A

Protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Glucorticoids

In plasma also

Alpha 2 globulin synthesized by the liver, 90% of circulating hormone

A

Corticosteroid binding globulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Glucorticoids

I plasma also, remaining free or loosely bound to

A

Albumin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Glucorticoids

Large capacity
Decrease affinity for cortisol

A

Albumin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Largely bound to albumin than CBG

A

Synthetic corticosteroids (dexamethasone)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Glucorticoids

1% excreted unchanged as free

A

Cortisol in urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cortisol

20% converted to cortisone by

A

11 hyroxysteroid dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Cortisol

Metabolism in

A

Kidney

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Cortisol

Excreted as

A

Dihydroxy ketone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Cortisol

Measured as

A

17 hydroxysteroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Cortisol

Conjugated with

A

Glucoronic acid or

Sulfate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

2 genes for corticoid receptor

A

Glucorticoids receptor

Mineralocorticoid receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Classic ligand activated glucocorticoid receptor

A

Hgr alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Dose not bind glucocorticoids

Inhibit effects of hormone activated hGR

A

hGR beta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Glucocorticoid binding domain

A

Carboxyl terminal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Cortisol

DNA binding domain

A

Middle of CHON
9 cysteine residues
2 fingers
ZINC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Transactivation activity of receptor

Increase specificity

A

Amino terminal domain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Cortisol

Steroids receptor co regulators

A

Co activator

Co repressors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Cortisol
Physiologic effect

Homeostatic responses by

A

Insulin and glucagon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Cortisol

Stimulate in fasting state

A

Gluconeogenesis

Glycogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Cortisol

Metabolic effects

A

Gluconeogenesis
Lipogenesis
Lipolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Cortisol

Catabolic and anti anabolic effect on bone

A

Osteoporosis

Cushing syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Catabolic and anti anabolic effects on children

A

Decrease growth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Cortisol

Effect in inflammation

A

Function of leukocyte
Suppress cytokines and chemokines
Increase neutrophils
Decrease lymphocyte, monocyte, eosinophils and basophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Cortisol

Anti inflammatory and immunosupresive effect

Lahat decrease, macrophage
Antigen or mitogen response
Prostaglandin (kaya na activate si phospholipase A2)
Mast cell
Capillary permeability
Decrease din si histamine na nag rerelease ng basophils

Except, kasi sya lang ang increase

A

Neutrophils

Kapag nakita mo si leukocytes, sama mo na rin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Increase amount of glucocorticoids

A

Initially - insomnia and euphoria lead to deppresion

Late- increase ICP (pseudo tumor cerebri)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Cortisol

If given chronically it will suppress

A

ACTH
Growth hormone
TSH
LH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Cortisol

If given in large dose for

A

Peptic ulcer

Fat redistribution Antgonize effect of vitamin D on Ca absorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Cortisol deficiency

A

Basta may kinalaman sa pag ihi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Synthetic corticosteroids

Source

A

Cholic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Synthetic corticosteroids

Prednisone rapidly converted to active product

A

Prednisolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Adrenocortical insufficiency

A

Acute and chronic Addison disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Chronic Addison

Characterized by

A

Weight loss
Hypotension
Hyperpigmentation
Inability to maintain blood glucose during fasting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Chronic Addison

Primary adrenal insufficiency

A

Hydrocortisone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Chronic Addison

Supplemented by

A

Fludrocortisone a salt retaining hormone

Synthetic long acting and devoid of salt retaining activity should not be administered

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Acute Addison

Immediate treatment

A

Large amount of parenteral hydrocortisone like
Sodium succinct and phosphate

Pwede ka mag bigay ng salt retaining hormone kung ang hydrocortisone level mo ay 50mg/day na

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Adenocortical hypo and hyper function

A

Congenital adrenal hyperplasia
Cushing syndrome
Aldosteronism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Congenital adrenal hyperplasia

Cause

A

Decrease or lack of 21 beta hydroxylase activity

Increase 17 hydroxy progesterone

44
Q

Congenital adrenal hyperplasia

If defects is in 11 hydroxylation

A

Increase deoxycorticosterone that leads to

HPN with or without hypokalemia

45
Q

Congenital adrenal hyperplasia

If defect is in 17 hydroxylation (adrenal and gonads)

A

Hypogonadism

46
Q

Congenital adrenal hyperplasia

Best treatment for infant

A

IV hydrocortisone

47
Q

Congenital adrenal hyperplasia

For stabilized patient

A

Oral hydrocortisone

48
Q

Congenital adrenal hyperplasia

Greater ACTH suppression with increasing growth hormone

A

Prednisone

49
Q

Congenital adrenal hyperplasia

Orally with added salt to maintain BP, renin activity and electrolytes

A

Fludrocortisone

50
Q

Cushing syndrome

Result of bilateral adrenal hyperplasia secondary to

A

ACTH secreting pituitary adenoma

51
Q

Cushing syndrome

Treatment

A

Surgery
Radiation
Resection

Drug- 300 mg soluble of Hydrocortisone ( continous on the day of surgery dapat slow lang ha.

52
Q

Cushing syndrome

If rapid reduction of hydrocortisone

A

Withdrawal syndrome

Joint pain
Fever

53
Q

Aldosteronism

Primary aldosteronism

Clinical findings

A 
HPN
Weakness
Tetany - dahil sa renal loss of K
Hypokalemia
Alkalosis
Increase Na
54
Q

Aldosteronism

Secondary aldosteronism

A

Decrease renin and angiotensin 2 activity

55
Q

Aldosteronism

Treated with

A

Fludrocortisone or

Deoxycorticosterone acetate IM for 3 days

56
Q

Aldosteronism

Diagnostic and therapeutic

A

Spironolactone

57
Q

Diagnosis of Cushing syndrome

A

Dexamethasone suppression test

58
Q

Urine is assayed for cortisol or metabolites

A

Liddle’s test

59
Q

Lung maturation in the fetus

A

IM betametasone

60
Q

Medium and intermediate acting Glucorticoids

A

Prednisone and prednisolone

61
Q

Prolonged therapy is anticipated

A

CXR and tuberculin test for TB

62
Q

Major undesirable effect

A

Iatrogenic Cushing syndrome

63
Q

Patients treated with glucocorticoids should be on

A

Increase CHON and potassium enriched diets

64
Q

Aldosterone

Synthesized in

A

Zona glomerulosa

65
Q

Aldosterone

Produce stimulation of its release

66
Q

Decrease section of Cortisol while increasing secretion of aldosterone

A

Decerebration

67
Q

Aldosterone

Promotes

A

Reabsorption of Na in distal convoluted and cortical collecting tubules
Excretion of K and hydrogen

68
Q

Precursor of aldosterone

A

Deoxycorticosterone

69
Q

Deoxycorticosterone DOC for

A

Adenocortical carcinoma

Congenital adrenal hyperplasia

70
Q

Potent steroid with both glucocorticoid and mineralocorticoid activity

A

Fludrocortisone

71
Q

DHEA additional effects

A

Interaction with GABA and glutamate receptors
LUPUS
Women with adrenal insufficiency

72
Q

Blocks conversion of cholesterol to pregnenolone

A

Aminoglutethimide

73
Q

Aminoglutethimide

Decrease or eliminate estrogen production in patients with

A

Carcinoma of the breast

74
Q

Aminoglutethimide

Adverse effect

A

Lethargy and skin rash

75
Q

Aminoglutethimide

Can be use in conjunction with

A

Metyrapone or

Ketoconazole

76
Q

Aminoglutethimide

Decrease secretion in patients with Cushing do not respond to

77
Q

Aminoglutethimide

Enhance metabolism of

A

Dexamethasone

78
Q

Anti-fungal imidazole

A

Ketoconazole

79
Q

Potent, nod selective inhibitor of adrenal and gonadal steroid synthesis

A

Ketoconazole

80
Q

Ketoconazole

Treatment

A

Cushing syndrome

81
Q

Ketoconazole

Adverse effect

A

Hepatotoxicity

82
Q

Selective inhibitor of steroid 11 hydroxylation, interfering with corticosterone synthesis

A

Metyrapone

83
Q

Metyrapone

Related to

84
Q

Metyrapone

Adverse effect

A

Transient dizziness and GIT disturbance

85
Q

The only adrenal inhibiting medication that can be administered to pregnant women with Cushing syndrome

A

Metyrapone

86
Q

Metyrapone

Major adverse effect

A

Salt and water retention

Hirsutism

87
Q

Metyrapone

Pituitary function

A

Midnight orally

Blood drawn at 8am

88
Q

38 hydroxysteroid dehydrogenase inhibitor

A

Trilostane

89
Q

Trilostane

Adverse effect

A

Gastrointestinal

90
Q

Newest of the steroid inhibitors

A

Arbiraterone

91
Q

Arbiraterone

Blocks

A

17 alpha hydroxylase and 17,20layse

92
Q

Arbiraterone

Prevented by concomitant administration of

A

Dexamethasone

93
Q

Arbiraterone

Treatment

A

Refractory prostate cancer

94
Q

RU 486

Antagonist at steroid receptor

A

Mifepristone

95
Q

Mifepristone

Blocking the

A

Glucocorticoid receptors

96
Q

Mifepristone

Bind to

A

Albumin

No affinity to CBG

97
Q

Drug related to DDT class of insecticides

98
Q

Mitotane

Non selective cytotoxic action on adrenal cortex in

99
Q

Mitotane

Treatment

A

Adrenal carcinoma

100
Q

Mitotane

Adverse effect

101
Q

Antagonist of mineralocorticoids

A

Spironolactone
Eplerenone
Drospirenone

102
Q

Spironolactone

A

7 alpha acethylthispironolactone

Slow onset

103
Q

Spironolactone TREATMENT

A

Primary aldosteronism

Hirsutism in women

104
Q

More selective than Spironolactone

A

Eplerenone

Adverse effect for hyperkalemia
Treatment for hypertension

105
Q

Antagonize the effect of aldosterone

A

Drospirenone

Progestin
Oral contraceptive

106
Q

Major glucocorticoid

Pharmacology 2nd Sem Finals (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions