Step 2 CK Flashcards
(Glipizide, glyburide, glimepiride) What kind of medications are these and what do they do?
Insulin medications and they increase endogenous secretion of insulin
How does metformin work?
Increases insulin sensitivity
What are the side effects for glyburide, glipizide and glimepriride?
Hypoglycemia and weight gain
How does rosiglitazone work?
Increase insulin sensitivity
What is the side effect of rosiglitazone?
weight gain and edema
How do they alpha glucosidase inhibitors work?
decrease intestinal absorption of carbohydrates
Whats the symptomatic treatment for hyperthyroidism?
Propanolol
Whats the main treatment for hyperthyroidisim?
Methimazole or PTU
Whats the definitive treatment for hyperthyroidism?
radioactive thyroid ablation or surgery
How do you treat thyroid storm?
IV propanolol and steroids
What kind of thyroid nodules has an increase risk of malignancy?
Cold nodules
Does increased uptake or decreased uptake hold an increase risk of malignancy?
decreased
What condition gives you persistent serum hypercalcemia, low calcium in urine, and normal PTH and no symptoms?
Familial hypocalcuric hypercalcemia
How do you treat hypercalcemia?
IV fluids and loop diuretics
Which cushings is suppressed with high dose dexamethasone?
Cushing disease
What is the treatment for a Prolactinoma?
Dopamine agonist (bromocriptine, cabergoline)
What is the treatment for pheochromocytoma?
Alpha blockers and beta blockers
What is the neuroimaging finding for schizophrenia?
Enlargement of cerebral ventricles
What is the neuroimaging finding for panic disorder?
decreased volume of amygdala
What is the neuroimaging finding for autism?
increased total brain volume
What is the neuroimaging finding for obsessive compulsive disorder?
abnormalities in orbitofrontal cortex and striatum
What is the neuroimaging finding for post traumatic stress disorder?
decreased hippocampal volume
What drug is contraindicated in cocaine induced STEMI?
Beta blockers
What is the test of choice for meconium ileus and hirschsprung disease?
contrast enema
If a patient has recurrent nephrolithiasis what would be the best advice for prevention of stones?
decrease Protein in the diet
What kind of hemangioma do you get in infancy?
Strawberry hemangioma (superficial hemangioma)
What is the side effect for methimazole?
Agranulocytosis
What is the side effect for PTU?
Hepatic failure
What is the side effect for the calcium channel blocker amlodipine?
Peripheral edema
How do you treat a scaphoid fracture?
immobilization
What is the best test to diagnose stones?
CT scan without contrast or ultrasound
What is the side effect for amiodarone?
Pulmonary toxicity
What is plummer-vinson-syndrome?
Where you have esophageal webs, iron deficiency anemia and glossitis
What is the musculature made out of in the upper 3rd of the esophagus?
Skeletal muscle
What is the musculature made out of in the lower 3rd of the esophagus?
smooth muscle
If you have painfull swallowing what imaging test would you do? (odonophagia)
Endoscopy
If you had difficulty swallowing what imaging test would you do? (dysphagia)
Barium swallow then endoscopy
What condition gives you chest pain, dysphagia and odynophagia after ingestion of hot or cold liquids?
Esophageal spasm
What is the treatment for esophageal spasm?
Nitrates or CCB
What muscle is affected in a Zenker diverticulum?
cricopharyngeus muscle
What is the most common type of esophageal cancer worldwide?
Squamous cell carcinoma
What is the most common esophageal cancer in the United States?
Adenocarcinoma
What is the risk factors for squamous cell carcinoma of the esophagus?
Alcohol and smoking
What is the risk factors for adenocarcinoma od the esophagus?
Barrets esophagus from Chronic GERD
What is the location in the esophagus where you are most likely to find squamous cell carcinoma?
upper and middle 3rds of the esophagus
What is the location in the esophagus where you are most likely to find adenocarcinoma?
lower 1/3 of the esophagus
How would you diagnose gastritis?
upper endoscopy
What is the triple therapy for H.pylori infection?
amoxicillin, clindamycin, omeprazole
What are stress ulcers and how do you treat them?
Stress ulcers include curling ulcers from burn injuries and cushing ulcers from traumatic brain injury. Treat with prophylactic PPIs
What is a krunkenberg tumor?
It is a gastric adenocarcinoma that metastasizes to the ovary
What is MALT?
MALT is mucosa-associated lymphoid tissue lymphoma which is a rare gastric tumor associated with chronic H. pylori infection that can be cured with triple therapy
What cancer is associated with an enlarged left supraclavicular lymph node?
Gastric cancer
What is the treatment for diarrhea caused by campylobacter?
Erythromycin
What is the most common cause of bacterial diarrhea?
campylobacter
What is the most common cause of pediatric diarrhea?
rotavirus
Whats the most common complication of C. diff?
toxic megacolon
What is the treatment for C.diff
metronidazole or vancomycin
What is the treatment for entamoeba histolytica?
metronidazole
How do you treat salmonella and shigella?
TMP-SMX
What does lactose break down into and what enzyme facilitates this?
glucose and galactose facilitated by lactase
What condition present with abdominal cramps, wheezing, cutaneous flushing, diarrhea, and right sided cardiac valvular lesions?
Carcinoid syndrome
What is the treatment for carcinoid syndrome?
octreotide
How do you diagnose carcinoid syndrome?
Urine levels of 5-HIAA
What condition gives you periodic crampy abdominal pain, bilious vomiting, abdominal distention and tenderness, no passing of flatus or stools and hyperactive bowel sounds?
Small bowel obstruction
What condition gives you continuous diffuse abdominal pain, nausea and vomiting, abdominal distenstion and tenderness, hypoactive bowel sounds and no flatus or bowel movements?
Ileus
What is the most common cause of acute lower GI bleeding in older patients?
Diverticulosis
What is Charcot’s triad and what condition is it associated with?
- RUQ pain
- Jaundice
- Fever/chills
Associated with ascending cholangitis
What condition is associated with an increased alkaline phosphatase level and increased direct bilirubin?
Choledocolithiasis
What is the next step in management for acute ascending cholangitis and choledocolithiasis?
ERCP
What are anti-smooth muscle antibodies associated with?
Autoimmune hepatitis
What is the treatment for acute hepatitis?
supportive care
What is the treatment for chronic hepatitis B?
interferon and lamivudine
What is the treatment for chronic hepatitis C?
interferon and ribavirin
What condition is associated with increased alkaline phosphatase, jaundice, pruritus, and positive antimitochondrial antibodies?
Primary biliary cirrhosis
What is the treatment for primary biliary cirrhosis?
ursodeoxycholic acid
What is the treatment for wilsons disease?
penicillamine
What is the hallmark finding in pancreatic cancer?
nontender, palpable gallbladder
What is the initial workup for a postmenopausal women with an adnexal mass?
transvaginal ultrasound and CA-125 level
What is the treatment for a patient with WPW syndrome who is in atrial fibrillation?
Procainamide
What is the test of choice for malrotation/volvulus?
upper GI series
What medications can you use to drive potassium intracellularly?
- Insulin
- Glucose
- Sodium bicarbonate
- Albuterol
What is the treatment for pseudotumor cerebri?
Acetazolamide
If you have blood at the beginning of urination what should you think of?
urethral injury
If you have blood at the end of urination what should you think of?
Bladder or prostate problems
At what weight should an infant not get immunizations?
Whats the mutation in Marfans syndrome?
Fibrillin 1 gene
What are the treatments for BPH
Alpha blockers (terazosin, tamsulosin) or finesteride
What is the treatment for bullous impetigo?
Oral antibiotics like clindamycin, cephalexin, dicloxcillian
What is the treatment for non-bullous impetigo?
topical muciprocin
What is the problem with giving lidocaine to a person who had a MI?
It can increase risk for asystole
What is the treatment for measles?
vitamin A and supportive care
What are the complications of bronchiolitis in infants?
apnea or respiratory failure
What are the complications of subarachnoid hemorrhage?
- Rebleeding after day 1
- Vasospasm after day 3
- increased ICP
- Seizures
- SiADH
What in the spinal fluid and confirm the diagnosis of subarchnoid hemorrhage?
Xanthrochromia
recurrent stones since childhood, hexagonal crystals on urnalysis and positive cyanide nitroprusside test is associated with what condition?
Cystinuria
What is the abnormality in cystinuria?
Defective amino acid transport
Pagets disease of the breast is associated with what kind of cancer?
Adenocarcinoma
What biopsy finding are suggestive of bullous pemphigoid?
IgG and C3 deposits at the dermal-epidermal junction
What are the autoantibodies targeting in pemphigus vulgaris?
desmoglein
What are the autoantibodies targeting in bullous pemphigoid?
hemidesmosomes
Pronator drift is associated with what type of brain abnormality?
upper motor neuron disease
Which cause of direct hyperbilirubinemia gives you dark granular pigment in the hepatocytes?
Dubin johnson syndrome
Leads 2, 3, AVF correlates with what kind of MI?
Inferior MI
Whats the antidote to heparin?
Protamine sulfate
What is cryoprecipitate?
More concentrated form of fresh frozen plasma. Contains factor 8 and fibrinogen
What is the diagnostic test for vWD?
ristocetin cofactor assay
What is the treatment for vWD?
DDVAP(desmopressin)
What is the difference between the labs in vWD and hemophilia?
In vWD there is platelet dysfunction so the bleeding time and PTT is prolonged but in hemophilia PTT is prolonged
What 3 things can give you microangiopathic hemolytic anemia that leads to schistocyted on peripheral blood smear?
- HUS
- DIC
- TTP
What is the treatment for TTP?
steroids and plasmapheresis
What is the treatment for ITP?
Steroids and IVIG
What is contraindicated in patients with HUS?
antibiotics
What are some specific tests for iron deficiency anemia?
Increased RDW and low ferritin levels
elevated MMA and elevated homocysteine is associated with what?
b12 deficiency
Normal MMA and elevated homocysteine levels are associated with that?
folate deficiency
What is indicative of a positive schilling test?
When a patient suspected of B12 deficiency is given radiolabed B12 and it comes out in the urine. Tell you there is a B12 deficiency
When you have increased LDH levels and decreased haptoglobin what does that tell you?
Hemolysis
The presence of auer rods are indicative of what condition?
AML
What is the translocation for the philadelphia chromosome and what condition is it associated with?
t(9;22) associated with CML
What is the preferred treatment for the M3 subtype of AML?
All trans-retnoic acid therapy
What chromosome translocations are associated with M3 subtype of AML?
Chromosome 15 and 17
Smudge cells are associated with what condition?
CLL
What is the treatment for CML
imtinab
Reed Sternberg cells are associated with what condition?
Hodgkins lymphoma
Which type of hodgkins disease has the best prognosis?
Lymphocyte predominant
What symptoms should raise suspicion for multiple myeloma?
anemia, renal failure and bone pain
Dutcher bodies are characteristic of what disease?
Waldenstrom’s macroglobulinemia
What is AL amyloid associated with?
multiple myeloma and Waldenstroms macroglobulinemia
What is AA amyloid associated with?
chronic inflammatory diseases
What is graft vs host disease?
Its a type of allogenic infection where donot T lymphocytes attack host tissues in the skin, liver and GI tract
What is the treatment for graft vs host disease?
high dose steroids
Whats the problem in hyperacute transplant rejection?
Preformed antibodies ABO incompatability
When would you see a reaction in hyperacute transplant rejection and what would that reaction be?
within minutes and vascular thrombi or ischemia
What is the problem in acute transplant rejection?
T cell mediated response
What are the side effects of HCTZ diuretic?
hyperglycemia, hyperlipidemia, hyperuricemia, hypokalemia, hypomaganesium, hyponatremia
What is bronchoalveolar lavage used for?
to evaluate for malignancy or opportunistic infections like PCP
What is the single most important prognostic factor in breast cancer?
TNM staging
Does central cord syndrome affect the lower extremeties or the upper extremeties?
upper extremeties
What is the treatment of choice for syphillis?
Penicillin
What is a patient is allergic to penicillin, what is the treatment for syphillis?
doxycycline
What is a patient is pregnant with syphilis and they are allergic to penicillin, what is the treatment?
desensitized penicillin
What is a patient has tertiary syphillis and they are allergic to penicillin, what is the treatment?
ceftriaxone
Ankylosing spondylitis is associated with what eye condition?
ANterior uveitis
What is the treatment for gastroparesis?
metoclopromamide
What is the management of suspected spleen injury?
If hemodynamically unstable do exploratory laparatomy. If hemodynamically stable do a CT scan and decide if surgery is needed
If you suspect endometriosis what is the best way to test for it?
Laparascopy
What is the treatment for Printzmetal angina?
Nitrates or CCB
What are the contraindications to rotavirus vaccination?
- History of intussusception
- History of GI abnormalities
- Anaphylaxis
- SCID
After diagnosing a patient with Guillain-Barre syndrome what is the most important next step in management?
Assess pulmonary function with spirometry
What receptors are affected in Lambert Eaton syndrome?
Presynpatic voltage gated calcium channels
What receptors are affected in Myasthenia gravis?
Postsynaptic acteylcholine receptors
Whats unique about blastomycosis?
Endemic in Wisconsin, Mississippi, Ohio. Has pulmonary, skin, and lytic bone lesion findings
What conditio can give you these findings; pericardial calcifications, prominent x and y descents, fatigue and dyspnea and fluid overload?
Constrictive pericarditis
Where are the endemic areas for tuberculosis constrictive pericarditis?
Africa, India and China
What is the treatment for tinea capitis?
Oral Griseofulvin
How do you treat uric acid stones?
Alkinaztion of the urine with potassium citrate
What is the management for spontaneous bacterial peritonitis?
Diagnostic paracentesis
What are the most likely cultured bacteria in spontaneous bacterial peritonitis?
E.coli and Klebsiella
Malabsorption, increased alk phos and PTH, decreased calcium and phosphorus are associatef with what condition?
Osteomalacia
What is the problem in osteomalacia?
Vitamin D deficiency and impaired osteoid matrix mineralization
What is the treatment for hairy cell leukemia?
Cladribine
What kind of gait do you get with parkinson disease?
hypokinetic gait
Malabsorption, increased alk phos and PTH, decreased calcium and phosphorus are associatef with what condition?
Osteomalacia
What is the problem in osteomalacia?
Vitamin D deficiency and impaired osteoid matrix mineralization
What is the treatment for hairy cell leukemia?
Cladribine
If i have a patient with increased serum iron, decreased TIBC and normochromic and hypochromic RBCs what condition should i be thinking of?
Sideroblastic anemia
What is the treatment for sideroblastic anemia?
Pyridoxine
What is the next step in treatment of a patient who is having an acute excerbation of COPD who has been given short acting beta agonists, steroids and antibiotics and still isnt responding to treatment?
Noninvasive positive pressure ventilation
What is the treatment for stable angina?
- Beta blockers
- CCB
- Nitrates
Menniers Disease affects which part of the ear?
Inner ear
What is the treatment for SVT?
Adenosine
What is the treatment for Ventricular tachycardia?
Amiodarone or lidocaine
What are the metabolic abnormalities in tumor lysis syndrome?
- Hyperuricemia
- Hyperkalemia
- Hyperphosphatemia
- Hypocalcemia
What is the most common cause of pneumonia from 6wks-18yrs?
RSV
What is the most common cause of pneumonia in the elderly?
Strep pneumo
What is the most common cause of pneumonia in young adults (18-40)?
Mycoplasma pneumonia
What is the most common cause of pneumonia in adults?
Strep pneumo
What is the most common cause of pneumonia in hospital setting?
Gram negatives
What is the most common cause of pneumonia in neonates?
Group B strep
What is the most common cause of pneumonia in COPD?
H. Flu
What is the most common cause of pneumonia in patients with cystic fibrosis?
kids-Staph aureus
Adults- psuedomonas
What is the most common cause of aspiration pneumonia?
Anaerobes
What is the most common cause of pneumonia in alcoholics/IV drug abusers?
Strep pneumo then klebsiella
What is the treatment for a patient with active TB?
2 months of isoniazide, rifampin, ethambutol and pyrazinamide then 4 months of isoniazide and rifampin.
What should you always give with isoniazide to prevent peripheral neuritis?
Vitamin B6
What is the treatment for latent TB with a positive PPD test?
9 months of isoniazide
What is the side effect of ethambutol?
optic neuritis
What is the side effect of rifampin?
turns body fluids orange
What is the side effect of isoniazide?
Peripheral neuropathy and hepatitis
What is the treatment for strep throat?
Penicillin
What can give you odynophagia, trismus, muffled voice, and deviated uvula away from lesion?
Peritonsillar abscess
What is the test of choice for sinus imaging?
CT scan
What is the treatment for acute bacterial sinusitis?
Amoxicillin/clavulanate
What is the treatment for coccidioidomycosis?
Fluconazole
What is the most common cause of postviral pneumonia?
Staph aureus
What is the prophylactic treatment for meningitis?
Rifampin
What is the most common cause of meningitis for elderly patients?
Strep pneumo
What is the most common cause of meningitis for patients 6-60yrs?
N. meningitidis
What is the most common cause of meningitis for neonates?
Group B strep
What is the most common cause of meningitis for kids from 6months-6yrs?
Strep pneumo
If you find RBCs in CSF without a history of trauma what should you start to think of?
HSV encephalitis
What is the treatment for HIV encephalitis?
IV acyclovir
What is the treatment for CMV encephalitis?
IV ganciclovir
What type of infection gives you CSF with elevated proteins, low glucose, and elevated WBCs?
Bacterial meningitis
What type of condition gives you CSF with high elevated opening pressure?
Pseudotumor cerebri
If you have a patient with a triad of headache, fever, and focal neurological deficit what should you be suspicious of?
Brain abscess
What is the treatment for a pregnant HIV+ patient who is not currently being treated?
zidovudine for mom and baby
What is the only live vaccine you can give HIV+ patients?
MMR
What is the treatment for cryptococcal meningitis?
IV amphotericin B
An HIV+ patient from Ohio presents with low grade fever, dry cough, malaise, weight loss, hepatosplenomegaly, pancytopenia, hilar lymphadenopathy and palatal ulcers. What condition is this?
Disseminated TB
What is the treatment for PCP?
TMP-SMX
What organs does CMV hit?
eyes, brain, GI, lungs
Foamy macrophages with acid fast bacilli?
mycobacterium avium
How do you treat mycobacterium avium?
Clarithromycin
If i have an HIV+ patient with a CD4 cell count
Azithromycin
What is the treatment for toxoplasmosis?
pyrimethamine+sulfadiazine
What is the prophylactic treatment for toxoplasmosis?
TMP-SMX or pyrimethamine+dapsone
If i have HIV and a CD4 cell count
PCP
If i have HIV and a CD4 cell count
Toxoplasmosis
If i have HIV and a CD4 cell count
Mycobacterium avium
What condition gives you these 3 stages….1. painless transient papule or ulcer, 2. painfull swelling of inguinal nodes, 3. anal pruritus with discharge, rectal strictures, elepantiasis?
Lymphogranuloma venereum
What is the treatment for chlamydia?
doxycycline
What is Reiters syndrome?
conjunctivitis, urethritis, arthritis
What is the treatment for gonorrhea?
ceftriaxone
If i have a patient with a suspected UTI and increased urine pH what should i think of?
infection with proteus mirabilis
What is the treatment for an uncomplicated UTI?
Nitrofurantoin or TMP-SMX 3-5days
What is the treatment for a UTI in a pregnant woman?
Nitrofurantoin 3-7days
What is the treatment for complicated UTI?
TMP=SMX or nitrofurantoin for 7-14days
What is first line therapy for pyelonephritis?
Fluoroquinolones
What is the first line chemoprophylaxis for chloroquine resistant malaria?
Mefloquine
What happens if you give a patient with mono ampicillin?
They develop a maculopapular rash
What rash starts on the wrists and ankles and spread centrally?
Rocky mountain spotted fever
What is the imaging test of choice for osteomyelitis?
MRI
Which immunosuppressant can cause gum hypertrophy?
cyclosporine
What is the treatment for dermatitis herpatiformis?
Dapsone
What condition could give you proximal muscle weakness in the lower extremities, difficulty ascending or descending stairs or rising from a seated position?
Polymyositis
What condition gives you recurrent pyogenic infections at 6 months of age with decreased concentrations of IgG, IgA, IgM, and IgE along with decreased B cells?
Brutons agammaglobinemia
What is the treatment for malignant otitis externa?
Ciprofloxacin
What can give you envelope shaped crystals?
ethylene glycol poisoning
What back condition is excerbated by exstension of the spine (standing and walking downhill) and relieved by flexion (sitting and walking uphill)?
Lumbar spinal stenosis
What are the serious side effects associated with cyclophospamide?
hemorrhagic cystitis, bladder carcinoma, sterility and myelosuppression
How can you prevent the toxic affects of cyclophosphamide?
hydration and MESNA
What is the most common cause of pneumonia in nursing home residents?
Strep pneumo
What is the treatment for bacterial meningitis in immunocompromised patients?
Vancomycin, ampicillin, cefepime
What is the treatment for bleeding esophageal varices?
octreotide
If you have a patient in pre-term labor and it is determined that her baby has bilateral renal agenesis what is the next step in management of the patient?
Allow spontaneous vaginal delivery because the condition is incompatible with life
What condition can present after travel or being on a cruise ship and give you a pneumonia like illness with high fever, watery diarrhea, headache, confusion, and hyponatremia?
Legionella
How do you treat legionella?
Fluoroquinolone
What is advanced sleep phase disorder?
Inability to stay awake in the evening after 7pm. Leads to early morning insomnia
What is delayed sleep phase syndrome?
Inability to fall asleep at normal bedtimes (10pm-midnight)
What condition can give you acne with monomorphous erythematous papules distributed over the face, arms, and trunk with no open or closed comedones?
Sterid acne
what is the main pathopysiologic mechanism underlying acne vulgaris?
Androgen excess
When do you do hip ultrasound in a baby with hip dysplasia?
2wks-6months
When do you do hip x-ray in a baby with hip dysplasia?
4-6months
Which medication is contraindicated in cocaine induced chest pain?
Beta blockers
What is the drug of choice for cocaine induced chest pain?
Nitrates or calcium channel blockers
What condition can give you an IgM spike and hyperviscosity?
Waldenstroms macrogliobinemia
Patient has difficulty reading fine print and has to hold reading material at an arms length in order to read them. What condition does he have?
Presbyopia
What is the abnormality in presbyopia?
Loss of elasticity in the lens
What eye problem gives you central visual field loss in a patient over age 50?
Age related macular degeneration
What eye condition has increased lens opacity and difficulty with night vision and driving at night?
Cataracts
What eye condition has elevated intraocular pressure, peripheral visual field defects followed by central visual loss?
Open angle glaucoma
If a patient is determined to be legally brain dead do you need permission to take him off life support?
NO!
What radiologic finding is associated with pseudogout?
Chondrocalcinosis
What is the most common ear pathology in patient with HIV?
Serous otitis media
What kind of shoulder injury give you an abducted arm that externally rotated?
Anterior shoulder injury
What kind of shoulder injury gives you an adducted arm thats internally rotated?
Posterior disclocation
What kind of injury do you get when you fall on an outstretched hand?
Colles fracture (distal radius)
If you have a positive valgus stress test what does that tell you?
Medial collateral ligament tear
If you have a positve varus stress test what does that tell you?
Lateral collateral ligament
In a motor vehicle accident when you have a dashboard injury what conditions does that predispose you to?
Posterior disclocation of the hip and PCL injury
What nerve can cause wrist drop?
Radial nerve
What nerve can cause foot drop?
Peroneal nerve
What nerve can cause claw hand?
ulnar nerve
What nerve can be injured in a anterior shoulder disclocation?
Axillary nerve
What condition causes pain with reptitive stress and resisted strength testing?
Tendinitis
What condition can cause bowel or bladder dysfunction, impotence, and saddle area anesthesia?
cauda equina syndrome
What is the treatment for a herniated disk?
NSAIDS
What condition gives you lower back pain that radiates to the arms, buttocks, and legs and improves upon flexion at the hips?
Spinal stenosis
What condition can give you a soap buble appearance x-ray?
Giant cell tumor of bone
What is the treatment for an acute attack of gout?
NSAIDS
Whats a side effect of hydroxychloroquine?
retinal toxicity
What condition gives you splenomegaly, rheumatoid arthritis and neutropenia?
Felty syndrome
Which joint is spared in RA but is present in OA?
DIP joint
What endocarditis is associated with lupus?
libman Sacks endocarditis
What is the treatment for Raynauds phenomenon?
Calcium channel blockers
What is the treatment for fibromyalgia?
Antidepressant
What condition causes pain and stiffness in the shoulder and pelvic girdles?
polymalgia rheumatica
What is the treatment for polymalgia rheumatica?
Steroids
What condition presents in a kid with arthritis and evanescent salmon colored rash?
Juvenile idiopathic arthritis
What is the time frame to use tPA in a stroke?
within 3hrs from onset of symptoms
How do you treat increased ICP?
Mannitol and hyperventilation raising the head of the bed
In the setting of severe hypertension or hemorrhagic stroke what is the treatment?
IV labetalol or nicardipine
If you have 100% occlusion of a carotid artery should you do a carotid endarterectomy?
NO!!!!
What is the single greatest risk factor for stroke?
HTN
What kind of condition can cause pseudodementia in the elderly?
subdural hematoma
If you have an intracerebral hemorrhage and start to develop a fixed dilated pupil that goes down and out what should you think of?
Uncal herniation
What neurotransmitter is associated with migraine headaches?
Serotonin
red wine in a young female is a trigger for what condition?
migraine
How do you prophylactically treat a migraine headache?
Anticonvulsants, beta blockers, CCB, TCA’s
If you have already developed a migraine headache what is the treatment?
NSAIDS or triptans
What bacteria is the most common cause of carvernous sinus thrombosis?
Staph aureus
What is the imaging test of choice for cavernous sinus thrombosis?
MRI
What kind of seizure has progressive jerking of body regions, hallucinations, but no loss of consciousness?
Simple partial seizure
What kind of seizure has episodes of lip smacking associated with impaired level of consciousness followed by confusion?
Complex partial seizure
What is the treatment of choice for partial seizures?
phenobarbital
What is the treatment for acute seizures lasting longer than 2 minutes?
benzodiazepine
What is the treatment for generalized tonic clonic seizures?
Phenytoin
What condition gives you a 3 second spike and wave discharge pattern?
Absent seizure
What is the first line treatment for an absent seizure?
Ethosuximide
What is the second line treatment for an absent seizure?
Valproic acid
How do you induce an absent seizure?
hyperventilation
What conditions gives the following EEG finding…. hypsarrhythmia?
infantile spasm
What is the treatment for infantile spasm?
ACTH
What condition gives you an EEG finding of slow spike and wave complexes?
Lenox-Gastaut syndrome
What is benign paroxysmal positional vertigo?
Condition where you get episodic short lived vertigo and nystagmus induced by postitional head changes. Not associated with nausea or vomiting
What is the abnormality in benign paroxysmal positional vertigo?
dislodged otolith
What is the treatment for benign paroxysmal positional vertigo?
Modified Epley maneuver
What condition can give you recurrent vertigo with auditory symptoms?
Menieres disease
What condition can give you acute onset of severe vertigo, gait instability, nausea, vomiting and nytstagmus?
Acute vestibular neuritis or labyrinthitis
What condition causes recurrent vertigo without auditory symptoms?
Vestibular migraine
What condition gives you proximal muscle weakness that gets worse as the day progresses. Also has dysarthria, dysphagia, ptosis and double vision?
Myasthenia Gravis
What are some associated finding with mysthenia gravis?
thyrotoxicosis and thymoma
What is the diagnostic test for myasthenia gravis?
Edrophonium (tensilon) test
What is the treatment for myasthenia gravis?
pyridostigmine
What type of multiple sclerosis gives you the best prognosis?
relapsing and remitting
What is the treatment for multiple sclerosis?
interferon
What is the treatment for acute excerbations for multiple sclerosis?
Corticosteroids
How do you diagnose guillian-barre syndrome?
nerve conduction studies and CSF with elevated proteins
What is the treatment for guillian-barre syndrome?
Plasmapheresis and IVIG
What is the most common cause of death in alzheimers patients?
aspiration pneumonia or other infections
How do you definitively diagnose alzheimers disease?
autopsy
What condition causes significant changes in behavior and personality?
Picks disease
Whats abnormal in Picks disease?
Atrophy of the frontal and temporal lobes
What condition gives you myoclonic jerks, ataxia and dementia?
Creutzfeldt-Jakob disease
What is the inheritance for hungtington disease?
Autosomal dominant
bilateral hand tremor is associated with what condition?
Essential tremor
What is the inheritance for neurofibromatosis?
Autosomal dominant
What chromosomes can you find defect on for neurofibromatosis 1 and 2?
Chromosome 17 and 22
What are some symptoms of neurofibromatosis type 1?
cafe au lait spots, optic glioma, lisch nodules, neurofibromas
Bilateral acoustic neuromas are associated with what condition?
Neurofibromatosis type 2
What condition is associated with ash-leaf spots, mental retardation and convulsive seizures?
Tuberous sclerosis
What heart condition is associated with tuberous sclerosis?
Rhabdomyoma
What is the dominant hemisphere?
left hemisphere
Where is broca’s area located?
posterior inferior frontal gyrus
In Brocas aphasia what happens to repetition?
Repetition is impaired
Where is the defect in Wernickes’s aphasia?
posterior superior temporal gyrus
A hard dilated painful red eye is associated with what condition?
closed angle glaucoma
What medication should you avoid in closed angle glaucoma?
Atropine
Headaches triggered by darkness is associated with what condition?
closed angle glaucoma
A fundoscopic exam that shows cupping of the disc and loss of peripheral vision is associated with what condition?
open angle glaucoma
What is the diagnostic test for open angle glaucoma?
Tonometry
What condition is associated with a cherry red spot and sudden painless unilateral blindness?
Central retinal artery occlusion
When should you hear fetal heart tones?
10-12wks
When should you appreciate fetal movement?
17-18wks
When is ultrasound most reliable to determine gestational age?
first trimester
When can you start to see a intrauterine pregnancy on ultrasound?
B-hCG of 1000-1500
When should you get a B-hCG level?
- Diagnose pregnancy
- Diagnose and follow ectopic pregnancy
- monitor trophoblastic disease
- Screen for fetal aneuploidy
How is the renal flow and GFR affected in pregnancy?
Both increases
How much folic acid is needed to prevent neural tube defects in a lady with history of neural tube defects in previous pregnancy?
4mg
How much folic acid is needed in pregnant women?
0.4mg
On your initial OB visit what test are you ordering?
CBC, Rh factor, type and screen, UA and culture, rubella antibody titer, HBsAg, RPR/VDRL, gonorrhea and chlamydia, PPD, HIV, Pap smear, tay-sachs and cystic fibrosis
When should the Quad screen be offered?
15-22wks
When do you do the glucose tolerance test in pregnancy?
24-28wks
When do you do the RhoGAM for Rh- women?
28wks
When do you do the GBS culture?
35-40wks
What does the QUAD screen consist of?
- MSAFP
- Inhibin A
- B-hCG
- Estriol
What is the QUAD screen useful for?
Detecting chromosomal abnormalities
What things can cause an elevated AFP level?
neural tube defects, incorrect dating, abdominal wall defects, fetal death, multiple gestation, placental abruption
What things can cause a reduced AFP?
Trisomy 21 and 18, incorrect dating, fetal demise
What is PAPP-A?
This is an associated pregancy protein that is screened for at 9-14wks that can detect trisomy 18 and 21
What would the quad screen show for a patient with down syndrome?
- AFP decreased
- Estriol decreased
- B-hCG increased
- Inhibin A increased
What would the quad screen show for a patient with edwards syndrome?
- AFP decreased
- Estriol decreased
- B-hCG decreased
- Inhibin A decreased
What is chorionic villus sampling?
Test done around 10-12wks gestation where you aspirate placental tissue for genetic diagnosis.
What is amniocentesis?
Test done around 15-20wks gestation where you aspirate amniotic fluid for genetic diagnosis.
When is an amniocentesis indicated?
- Advanced maternal age(>35)
- RH sensitized pregnancy
- Abnormal quad screen
- determine fetal lung maturity
What is a spontaneous abortion?
Loss of pregnancy prior to 20th wk of pregnancy
What is the most common cause of first trimester spontaneous abortion?
chromosomal abnormalities
What torch infection gives you periventricular calcifications?
CMV
What torch infection gives you blueberry muffin purpuric rash, hearing loss and cataracts?
Rubella
What torch infection gives you hydrocephalus, chorioretinitis, and intracranial calcifications?
Toxoplasmosis
What torch infection gives failure to thrive, bacterial infections and increase incidence of upper and lower respiratory tract infections?
HIV
What torch infection gives you snuffles, saddle nise, maculopapular rash, and hepatomegaly?
Syphilis
What is the treatment for an incomplete spontaneous abortion?
manual aspiration or a D&C
What is the treatment for intrauterine fetal demise?
Induce labor
What is the management of HSV in a pregnant women in the third trimester?
If the patient has active lesions upon delivery then perform a C-section
How many cm is the active stage of labor?
4cm-10cm
What are the stages of labor?
- Onset of cervical dilation
- Complete cervical dilation until the delivery of the baby
- Delivery of baby until the delivery of placenta
What are some reasons for fetal bradycardia on heart rate monitor?
Cord prolapse, uterine hyperstimulations, and rapid fetal descent
What are some reasons for fetal tachycardia on heart rate monitor?
maternal fever, hypoxia, fetal anemia
What is a normal reactive non stress test?
Greater than 2 accelerations of 15bpm above baseline lasting for 15 seconds over a period of 20minutes
If you have a nonreactive stress test what is the next step in management?
Biophysical profile
What is a biophysical profile?
A test that uses a real time ultrasound to assign a score measuring fetal tone, fetal breathing, amniotic fluid, movement, and NST
What is the amniotic fluid value for oligohydramnois?
AFI
If morning sickness persists beyond the first trimester what condition should you think of?
hyperemesis gravidarum
What are some causes of hyperemesis gravidarum?
Multiple gestations, first pregnancy, or molar pregnancy
What is the next step in management if you suspect a patient to have hyperemesis gravidarum?
rule out molar pregnancy with ultrasound and BhCG
What is considered abnormal for a 50gram glucose tolerance test performed at 24-28wks gestation?
> 140mg/dL
If you have an abnormal 50gram glucose tolerance test what is the next step in management?
Confirm with a 3hr 100gram oral glucose tolerance test
What are the abnormal valies for a 3hr 100 gram oral glucose tolerance test?
- Fasting >95
- 1hr >180
- 2hr >155
- 3hr> 140
What are the goal glucose numbers for a patient with gestational diabetes?
Fasting
What is the most common complication for a pregnant women with uncontrolled pregestational diabetes?
congenital malformations
What if a patient is a prediabetic and is pregnant what are her glucose goals?
Fasting is
What is the cutoff to be diagnosed as gestational HTN?
HTN that develops >20wks gestation
What are the appropriate HTN medications to use in pregnancy?
Methyladopa, labetalol, nifedipine
What is preeclampsia?
Condition in pregnancy occurring after 20wks gestation where the patient develops HTN, proteinuria and edema
What is the cutoff to be determined to have proteinuria associated with preeclampsia?
> 300mg
What are the characteristics of severe preeclampsia?
- BP >160/110
- proteinuria >5g
- headache
- blurred vision
- HELLP syndrome
- RUQ pain
- Clonus
What are some signs of magnesium toxicity?
Loss of DTRs, respiratory paralysis and coma
How do you treat magnesium toxicity?
IV calcium gluconate
What is the karotype for a complete molar pregnancy?
46XX
Which molar pregnancy contains fetal tissue?
Incomplete molar pregnancy
What is the karotype for incomplete molar pregnancy?
69XXY
Which molar pregnancy does not contain fetal tissue?
complete molar pregnancy
A snowstorm appearance on pelvic ultrasound is characteristic of what condition?
Molar pregnancy
What is considered postpartum hemorrhage?
> 500ml for vaginal deliveries
>1000ml for C-section
What is the management for severe postpartum hemorrhage?
uterine artery embolization
What condition causes hypogonadotropin deficiency and anosmia?
Kallman syndrome
What is the age for premature menopause
before age 40
What is the diagnostic test sequence for a patient with suspected secondary amenorrhea?
- pregnancy test
- TSH/prolactin
- progestin challenge
What is the meaning of a progestin challenge test coming back positive?
Means there is anovulation.
What is the meaning of a progestin challenge test coming back negative?
Means there is estrogen deficiency
The classic triad of pain, menorrhagia, and enlarged uterus is associated with what condition?
Adenomyosis
What is the test of choice for endometriosis?
Laparoscopy or laparotomy
What is the treatment for endometriosis?
OCPs
What is the most common complication of endometriosis?
Infertility
What is treatment for menorrhagia?
OCPs or mirena IUD
A young female presents with a fever and abdominal pain with a positive chandelier sign what condition are these symptoms associated with?
Tubo-ovarian abscess
What is the most common complication of tamoxifen therpay?
Endometrial cancer
If your pap smear shows ASCUS what is the next step in management?
HPV test
If your pap smear shows ASCUS and you do a HPV test and it comes back negative what is the next step in management?
repeat pap smear in 1yr
If your pap smear shows ASCUS and you do a HPV test and it comes back positive what is the next step in management?
Colposcopy
What is urinary incontinence caused by coughing, sneezing or lifting?
Stress incontinence
What is the treatment for urinary stress incontinence?
Pessary, kegal exercises and vaginal vault suspension surgery
What kind of urinary incontinence is caused presented by a strong urge to void?
Urge incontinence
What is the treatment for urge incontinence?
Anticholinergics or TCAs
What type of urinary incontinence is presented by chronic urinary retension?
Overflow incontinence
What is the treatment for overflow incontinence?
Urethral catheter
What breast condition causes bloody nipple discharge?
Intraductal papilloma
What is the screening test for a female under 30 who presents with a breast mass?
Ultrasound
If you have a HER2/neu positive cancer what is the treatment?
Trastuzumab
If you have a estrogen and progesterone positive breast cancer what is the treatment?
Tamoxifen
What is the prophylactic treatment for a transplant patient against opportunistic infections?
TMP-SMX
What are the PFT finding is COPD?
- decreased FEV1/FVC ratio
- normal-decreased FVC
- normal -increased TLC
- decreased DLco
What drugs can cause interstitial lung disease?
Amiodarone, bleomycin, and nitrofurantoin
What is the treatment for sarcoidosis?
steroids