Stem cells (Hibaoui)

Question 1

What cells should be studied for understanding the molecular mechanisms of acute lymphoblastic leukemia in Down syndrome ?

Answer 1

Hematopoietic cells and B lymphocytes derived from iPSCs from monozygotic twins discordant for trisomy 21 (D21-iPSCs and T21-iPSCs).

Question 2

What are hematopoietic stem cells (HSCs) ?

Answer 2

Hematopoietic stem cells are stem cells that can give rise to specialized blood cells such as platelets, white blood cells and red blood cells.
Origin : bone marrow.