STDs and a couple of add-ons Flashcards
High risk pops (STDs, chlamydia, syphilis)
youth
chlamydia: black>Hispanic>white
syphilis: MSM account for 72% cases 2011, high rate of HIV coinfection
Vulvovaginal Candidiasis causative organism(s)
NOT AN STD
(U) Candida albicans
can be caused by other Candida sp. or yeasts (Candida glabrata, Candida tropicalis or Torulopsis glabrata)
Vulvovaginal Candidasis epidemiology
COMMON!
at least 75% of women experience 1 episonde
40-45% experience>1 episode
Vulvovaginal Candidiases Clinical Presentation
-Vulvar pruritis, external dysuria, burning, dyspareunia, swelling, redness, excoriation
-thick, curd-like vaginal discharge
NORMAL VAGINAL pH (<4.5)
Vulvovaginal Candidiasis: Risk Factors
taking antibiotics
immunocompromise (eg. HIV, DM, steroids)
body w/warm, most environment
Vulvovaginal Candidiases: Dx
- clinical presentation
- Testing:
a. wet prep (saline & 10% KOH) w/microscope visualization of budding yeast & hyphae
b. Candida culture
- spaghetti & meatballs
Vulvovaginal Candidiasis: UNCOMPLICATED tx
Uncomplicated: short course (103 days) of topical (vaginal) azole e.g. clotrimazole (OTC)
Vulvovaginal Candidaisis: COMPLICATED definition and tx
def: Recurrent (> or =4 episodes in 1 yr), severe, non-albicans, patient has uncontrolled DM or immune compromise
-tx w/longer duration (7-14 d) topical azole or oral fluconazole (Diflucan)
IF NON-ALBICANS, AVOID FLUCONAZOLE-pick a different azole
Vulvovaginal Candidiasis: tx of male partner
male partner DOESN’T NEED TX
UNLESS HE HAS BALANTIS (inflammation of the skin covering the glans of the penis)
Vulvovaginal candidiasis: pregnant patients tx
ONLY use TOPICAL txs in pregnant pts
What do you do if a patient has recurrent or difficult to tx yeast infections?
evaluate for DM, HIV
Bacterial Vaginosis: an STD?
NOT an STD
Vulvovaginal Candidiasis: an STD?
NOT an STD
Bacterial Vaginosis causative organism/background
results from disruption of usual, "healthy" vaginal microflora (Lactobacillus sp)-allows overgrowth of bacturea cause is (U) polymicrobial, often a/w Gardnerella vaginalis & Mobiluncus sp (gram variable anaerobes)
Bacterial Vaginosis: Clinical Presentation
vaginal irritation, thin white or gray discharge w/strong fishy odor
Bacterial Vaginosis: Risk factors
(although NOT an STD),
- New or multiple sex partners
- douche
- can affect women that are NOT sexually active
Bacterial vaginosis diagnosis (clinical criteria)
Clinical criteria (Amsel’s criteria) at least 3 of 4 present
- Thin white homogenous discharge
- Clue cells on microscopy
- Vaginal fluid pH>4.5
- Release of fishy odor when adding KOH solution (+whiff test)
Bacterial vaginosis: lab test
best LAB test is Gram stain-shows anaerobes known to cause BV & lack of Lactobacilli
-Gold Standard but NOT generally used clinically
Bacterial Vaginosis: tx
treat ALL PATIENTS WITH SXS
Metronidazole (Flagyl) orally for 7 days
-avoid EtOH while taking metronidazole
Metronidazole gel intravaginally for 5 dyas
Clindamycin orally or intravaginally
PREGO PTs: USE ORAL MEDS [just incase they have an infection higher up & to avoid premature birth]
Bacterial Vaginosis: male partner tx
male partner DOES NOT need tx
Bacterial Vaginosis: complications
- increases risk of acquiring & transmitting HIV
- increases risk of acquiring herpes, gonorrhea (GC) & chlamydia
- a/w PID (but BV is not believed to he a causative factor)
Trichomoniasis: causative organism & description
Trichomonas vaginalis: single celled protozoan parasite
Trichomoniasis: how common is this?
common (most common NON-VIRAL)
Trichomoniasis: sxs appear when
1-4 weeks after exposure
men (U) ASYMPTOMATIC: sxs<10% of cases [male sx: clear or mucopururent urethral dc &/or dysuria]
Trichomoniasis clinical presentation
- INCREASED VAGINAL pH (>4.5)
- vaginal irritation & malodorous, frothy, yellow-green discharge
- may see petechiae on cervix or vagina (“strawberry cervix”)
[although these are the classical sxs, they occur only in some cases]
Trichomoniasis: dx
-visualize motile organisms on wet mount
-swab (vaginal, cervical, some tests appropriate for male urethra)
-culture (may take up to 7 days)
other technologies: eg NAAT
-pap test may identify trich
-testing is difficult in males (a little “trick”:5-20% of men w/non-gonococcal urethritis (NGU) have trich
Nucleic Acid Amplification test (NAAT)
- biochemical technique used to detect the genetic material of an infecting organism
- faster than culture
- very sensitive (also preferred in males)
Trichomoniasis: tx
- treat everybody (pt & sex partners)
- Metronidazole (Flagyl) orally
- pt&partners should abstain from sex until tx is complete (high recurrence rate)
Trichomoniasis complications
increases risk of acquiring & transmitting HIV
Trichomoniasis: pregnancy considerations
trich increases risk of premature rupture of membranes, preterm delivery, low birth wt BUT TX NOT SHOW TO REDUCE RISKS
- tx recommended for pts with symptoms
- lactating women should withhold breastfeeding while taking metronidazole
Bacterial Vaginosis: microscopic appearahce
increased WBCs
decreased lactobacilli
many CLUE CELLS
Candidiasis: microscopic appearance
hyphae and buds
Trichomoniasis: microscopic appearance
normal epithelial cells
increased WBCs
trichomonads
Normal vaginal microscopic appearance
normal squamous epithelial cells
numerous lactobacilli
Bacterial Vaginosis common sxs
- discharge
- odor that gets works after intercourse, may be asymptomatic
Candidiasis: common sxs
- itching
- burning
- irritation
- thick, white discharge
Trichomoniasis: common sxs
- frothy d/c
- bad odor
- dysuria
- dyspareunia
- vulvar itching & brining
Normal vagina: amount of d/c, appearance of d/c
small amount of d/c
d/c is white, clear, flocculent
Bacterial vaginosis: amt of d/c and appearance of d/c
amt: often increased
appearance: thin, homogenous, gray-green, white, adherent
Candidiasis: amount of d/c & appearance of d/c
amt: sometimes increased
appearance: white, curdy, “cottage cheese-like”
Trichomoniasis: amount of d/c & appearance of d/c
Amt: increased
appearance: gray-green, frothy, adherent
Normal vaginal pH
3.8-4.2
Bacterial vaginosis vaginal pH
> 4.f
Candidiasis vaginal pH
normal (3.8-4.2)
Trichomoniasis vaginal pH
> 4.5
KOH “whiff test” (amine odor) present in?
Bacterial vaginosis (fishy) possibly present in Trichomonaisis (fishy)
Chlamydia: causative organism & gram stain
Chlamydia trachomatis
GRAM NEGATIVE BACTERIUM
Chlamydia epidemiology
most common BACTERIAL STI in the US
peaks in late teens, early 20s
Chlamydia: screening recommendations
- women < or =25 should be screened for chlamydia every year (screen older women w/risk factors)
- only screen higher risk males (correctional facilities, etc.)
- screen ALL PREGNANT PATIENTS
Patients infected with chlamydia are frequently co-infected with what
gonorrhea
Chlamydia presentation (in women, in men)
often asymptomatic, sxs 1-3 weeks after exposure
WOMEN: cervical d/c, vaginal bleeding, low abdominal pain, fever/chills, adnexal tenderness [adnexal=pain from ovary & fallopian tube]
MEN: irritated urethra(urethritis), penile d/c, dysuria
can cause oral & rectal infections
Chlamydia dx
Swab: cervical, vaginal or male urethral; various technologies (eg NAAT-gen most sensitive)
Urine: NAAT
Pharynx or rectal swab: NAAT, check w/lab to determine if there is a specific swab for the pharynx or rectal swab you need to use
Chlamydia tx: who do you treat
treat everybody [test(if possible) & tx pt & partners]
Chlamydia tx
tx everybody
Doxycycline orally x7d
OR
Azithromycin (Zithromax) single dose
no sex during tx
consider tx for gonorrhea too (assume coinfection)
retest in 3-4 months
pregnant pts: avoid doxycycline, pregnancy cat D
perform test-of-cure 3 weeks after therapy completion
Chlamydia complications
increases risk of acquiring & transmitting HIV
if left untx, can cause PID and associated complications
in males, can cause epididymitis
Chlamydia: pregnancy considerations
- may lead to preterm delivery
- may transmit to neonate during delivery
- a leading cause of CONJUNCTIVITIS(ophthalmia neonatorum) & PNEUMONIA in newborns
- can cause other respiratory tract infections
- AVOID DOXYCYCLINE IN PREGNANCY
Gonorrhea: causative organism & morph/gram
Neisseria gonorrhea-gram NEGATIVE DIPLOCOCCI bacterium
Gonorrhea background: when to symptoms occur, who do you screen
symptoms may occur 1-14 days after exposure
screen pts at risk
-pts often co-infected with chlamydia
Gonorrhea clinical presentation (women[W,4]and males[M,3], both [B,])
(like Chlamydia but more severe)
W: vaginal d/c, low abdominal pain, fever, cervical motion tenderness
M: irritated urethra (urethritis), white-yellowish-or green penile d/c, dysuria
B: can cause oral & rectal infections