STDs Flashcards
STDs that increase risk of HIV (7)
Chlamydia, gonorrhea, bacterial vaginosis, herpes, syphilis, chancroid, Klebsiella granulomatosis
Gonococcal urethritis
Incubation period
Dysuria
Discharge
Less than 4 days
Severe
Profuse yellow / green
Incubation period for nongonococcal (chalmydial) urtheritis
7-14 days
Severity of dysuria w/ gonococcus
Severe. Like peeing out glass shards.
Severity of dysuria w/ non gonococcus
Mild / moderate / intermittent.
Type of male discharge w/ gonococcus
Profuse yellow or green
Type of male discharge w/ nongonococcus
Slight, grey, can be mixed w/ mucous. May only be noticed in underwear upon wakening.
What stain is used for urethritis?
Diagnostic criteria
- Gram stain / methylene blue / gentian violet stain of discharge
- > 2 WBC per oil immersion field + gram neg intracellular diplococci (GNID)
- > 2 WBC per oil immersion field w/o GNID = NGU
Diagnosing urethritis (4)
Discharge seen on exam
Gram stain
Urinalysis: >10 WBC/HPF or positive leukocyte esterase (LE) on first void urine
PCR
Treating urethritis
GC
NGU
- N gonorrhoeae: ceftriaxone + azithromycin or doxycycline (if allergic to azithro)
- NGU: azithromycin or doxycycline
- ALL pxs treated for GC should be treated for Chlamydia
What is most common cause of persistent / recurrent NGU? What do you use to treat?
Mycoplasma genitalium is most common cause of persistent / recurrent NGU. Tx w/ azithro
Follow up for urethritis
Repeat testing in 3 months to check for reinfection.
Complications of urethritis (2)
C teach may cause epididymitis or reactive arthritis
Sxs of cervicitis
- Asymptomatic is common
- Sxs include abnormal vaginal discharge and intermenstrual bleeding (especially after sex). Usually NOT painful (pain may indicate PID).
2 most common causes of cervicitis
Neisseria gonorrheae and Chlamydia trachomatis
Diagnosing cervicitis
2 major
3 others
- Major diagnostic criteria (need at least one): (Muco)purulent endocervical exudate or sustained endocervical bleeding induced by cotton swab through os.
- Others – leucorrhea, gram stain, PCR of cervical / vaginal / urine specimens
- Neg gram stain does not rule out
What must always be done in the case of cervicitis?
Must ALWAYS evaluate for upper tract disease (PID), looking for adnexal / uterine tenderness
Treating cervicitis
- Treatment – same as urethritis
- N gonorrhoeae: ceftriaxone + azithromycin or doxycycline (if allergic to azithro)
- NGU: azithromycin or doxycycline
- ALL pxs treated for GC should be treated for Chlamydia
Follow up for cervicitis
- No test of cure, except for pregnancy or if GC regimen did not include ceftriaxone
- Repeat testing at 3-6 months
What is the #1 bacterial STD in the US?
Chlamydia
Pxs at risk of Chlamydia
Women 2x risk. Women under 25 y/o should be screened yearly.
Most common in ages 15-24. South.
AA’s at highest risk.
Serotypes of Chlamydia
- D-K: urethritis, cervicitis, neonatal infection
* L1-L3: lymphogranuloma venerum (LGV)
Elementary Body vs Reticulate Body
- Elementary body (EB) – Enters & Exits the cell
* Reticulate Body (RB) – Replicates in the cell
Gram stain for Chlamydia
Abundant WBCs but not intracellular diplococci (gonorrhea)
What percentage of pxs w/ Chlamydia are asymptomatic?
Men 42%, women 70%
Sxs of Chlamydia
Men: dysuria, discharge, pruritis
Women: discharge, bleeding, painful sex, dysuria
Both: proctitis
Complications of Chlamydia
Men: epididymitis, prostatitis, reactive arthritis
Women: PID (occurs in 20%), tubal infertility, ectopic pregnancy, chronic pelvic pain
Neonatal inclusion conjunctivitis Other name Cause Onset Treatment
- aka Opthalmia neonatorum
- Caused by Chlamydia
- Acquired during birth. Onset 5-12 days after birth.
- Tx w/ oral erythromycin
Neonatal C trach pneumonia
Onset
Associated sxs
Treatment
- Acquired during birth. Onset w/in 8 weeks.
- 50% of pxs will also have conjunctivitis. Peripheral eosinophilia may be present.
- Tx w/ ORAL erythromycin
Diagnosing Chlamydia
Women (3)
Men (2)
Both (1)
- Women – Mucopurulent discharge from cervix, sustained bleeding via cotton swab through os, always evaluate for PID
- Men – gram stain, UA on first void urine looking for nucleic acids
- PCR for both
Screening for Chlamydia
- Annual screening for sexually active women less than 25 y/o, or > 25 y/o w/ risk factors (new partner, poor condom use, sex work)
- Screening in 3rd trimester for pregnant women
- Annual screening for syphilis, Chlamydia, gonorrhea, and HIV for men at adolescent clinics, STD clinics, jail, or MSM
STD screening for men
Annual screening for syphilis, Chlamydia, gonorrhea, and HIV for men at adolescent clinics, STD clinics, jail, or MSM
Treating Chlamydia
Azithromycin or doxycycline
Follow up for Chlamydia
No test of cure unless pregnant
Repeat testing in 3 months
2nd most common bacterial STD in US
Gonorrhea
Epidemiology of gonorrhea
More common in women.
Age 15-24 is highest.
AA’s at highest risk.
South.
Risk of gonorrhea transmission (male vs female)
- Male → female 50-70% per exposure
* Female → male 20% per exposure
Mechanism of gonorrhea infection
Infects columnar / cuboidal epithelium. Pili help w/ attachment. Internalized, then released via basolateral membrane to disseminate.
What percentage of pxs w/ gonorrhea are symptomatic?
Men 90%
Women only 20%
1 complication of gonorrhea in men
Epididymyitis
How common is pharyngeal gonorrhea?
25% of pxs w/ urogenital gonorrhea. Almost always asymptomatic.