STD Dosing

Question 1

Uncomplicated gonorrhea therapy

Answer 1

1st Option:
- IM Ceftriaxone 500 mg (<150kg) - 1g (>150kg) single dose
- PO Doxycycline 100 mg BD for 7 days

2nd Option:
- IM Gentamicin 240 mg single dose
- PO Azithromycin 2g single dose

Question 2

Chlamydia therapy

Answer 2

• PO Doxycycline 100 mg BD 7 days
• PO Levofloxacin 750 mg OD 7 days
• PO Azithromycin 1g single dose

Question 3

Syphilis

Answer 3

Primary, Secondary, Early Latent
1) IM Benzathine Penicillin G 2.4 MU single dose
2) PO Doxycycline 100 mg BD 14 days

Late latent, Unknown duration, Tertiary
1) IM Benzathine Penicillin G 2.4 MU triple dose once weekly administration
2) PO Doxycycline 100 mg BD 28 days

Neurosyphilis
1) IV Crystalline Penicillin G 10-14 days
- 3-4 MU q4h OR
- Continuous infusion 18-24 MU/day
2) IM Procaine Penicillin G 2.4 MU daily + PO Probenecid 500 mg QDS 10-14 days
3) IV/IM Ceftriaxone 2g daily 10-14 days

Question 4

Genital Herpes

Answer 4

Acyclovir
- 1st episode:
(1) PO 400mg TDS 7-10 days OR
(2) IV 5-10 mg/kg q8h 2-7 days then PO to day 10
- Chronic Suppressive therapy:
PO 400mg BD
- Episodic therapy:
PO 800mg BD for 5 days or TDS for 2 days

Valacyclovir
- 1st episode: PO 1g BD 7-10 days
- Chronic Suppressive therapy: PO 500mg-1g OD
- Episodic therapy:
PO 500mg BD for 3 days or 1g OD for 5 days