STD

Question 1

HSV structure

Answer 1

ds DNA w lipid envelope

Question 2

HSV entry into host cell

Answer 2

directly fuses with PM in a pH-independent manner

Question 3

HSV IE, early, and late proteins

Answer 3

IE: transcriptional regulators (inc viral gene txn)

early: proteins involved in genome replication –> thymidine kinase, DNA pol
late: structural proteins

Question 4

HSV clinical importance of thymidine kinase

Answer 4

1: it phosphorylates ACV
2: mutations in TK lead to resistance to ACV

Question 5

HSV can form a specific cell type…

Answer 5

syncitia; infected cells can fuse with adjacent uninfected cells

Question 6

What test can dx HSV? what does it show?

Answer 6

Tzanck smear; multinucleated giant cells with NUCLEAR inclusion bodies

Question 7

HSV virus is maintained _____

Answer 7

extrachomosomally

Question 8

What is the only HSV gene expressed during maintenance of latency? what does it do?

Answer 8

LAT (latency-associated transcript)

prevents apoptosis of the infected neuron

Question 9

HSV 1 is associated with what diseases mainly?

Answer 9

fever blister
keratitis
encephalitis

Question 10

HSV 2 is associated with what diseases mainly?

Answer 10

cervicitis
vulvular and penile vesicles
meningitis

Question 11

T or F: skin, ocular, and urogenital lesions can be caused by either HSV1 or 2

Answer 11

T

Question 12

When is disseminated disease of HSV an issue?

Answer 12

immunocompromised pts and neonates

Question 13

recurrent infections are often limited due to presence of ___

Answer 13

neutralizing antibody

Question 14

Primary oral infection of HSV leads to ___

Answer 14

gingivostomatitis

Question 15

recurrent oral infection of HSV leads to ___

Answer 15

fever blisters