Staudinger Influenza Drugs Flashcards
What drug class prevents viral reproduction by budding from the host cell by cleaving sialic acid found on glycoproteins
Neuraminidase Inhibitors
What drug is indicated for influenza A and B infections that have been symptomatic for no more than 48 hours
Tamiflu (Oseltamivir)
Oseltamivir (tamiflu) can cause what type of reaction?
hypersensitivity
How does oseltamivir (tamiflu) interact with the flu vaccine?
don’t give flu vaccine within 48 hours after taking tamiflu and don’t take tamiflu until 2 weeks after flu vaccine
Is oseltamivir phosphate or oseltamivir carboxylate a substrate for cytochrome P450 or UGT enzyme isoforms?
neither
How is Zanamivir metabolized?
Zanamivir is not metabolized and is excreted almost exclusively by the kidney. It does not interact with CYP liver enzyme
What is peramivir?
IV neuraminidase inhibitor to treat uncomplicated flu for pts over 18 within 2 days of onset
How is peramivir administered?
IV
What is an example of a polymerase acidic endonuclease inhibitor that inhibits mRNA virus replication used to treat the flu?
Baloxavir
Who can take Baloxavir?
Children 12 and older who have had sx for 48 hours or less
What is peramivir BBW?
none
What is Baloxavir BBW
none
What drug interferes with the function of the transmembrane domain of viral M2 protein to prevent the release of infectious viral nucleic acid into the host cell in the tx of the flu?
Amantadine
How does Amantadine affect the immunogenicity of inactivated influenza virus?
It does not appear to interfere with the immunogenicity of inactivated influenza A virus vaccine
What is indicated for the prophylaxis and treatment of signs and symptoms of infection caused by various strains of influenza A virus?
Amantadine
