Statistics Flashcards
1++ evidence level
High quality systematic reviews of meta analysis of RCTs or RCTs with a very low risk of bias
1+ evidence level
Well conducted systematic reviews or metanalysis of RCTs or RCTs with a low risk of bias
1- evidence level
Systematic reviews or meta analysis of RCTs or RCTs with a high risk of bias
2++ evidence level
High-quality systematic reviews of case controls or cohort studies or high-quality case control or studies with a very low risk of confounding, bias or chance and high probability that the relationship is causal
2+ evidence level
Well conducted case control or cohort studies with a low risk of confounding, bias or chance and a moderate probability that the relationship is causal
2- evidence level
Case control or cohort studies with a high risk of confounding, bias or chance and a significant risk that the relationship is not causal
3 evidence level
Non-analytical studies e.g. case report, case series
4 evidence level
Expert opinions
A grade of recommendation
At least one systematic review met analysis or RCT rated as 1++ and directly applicable to target population
Or a systematic review of RCTs or a body of evidence consisting principle of studies rated as 1+ directly applicable to target population and demonstrating overall consistency results
B level recommendation
A body of evidence including studies rated as 2++ directly applicable to the target population and demonstrating overall consistency results.
Or extrapolated evidence from studies rate 1++ or 1+
C grade of recommendation
A body of evidence including studies rated as 2+ directly applicable to target population and demonstrating overall consistently of results.
Or extrapolated evidence from studies rated as 2+
D grade of recommendation
Evidence level 3 or 4
Or extrapolated evidence from studies rated as 2+
✔️ good practice points
Based on the clinical experience of the guideline development group
