Statins Flashcards
0
Q
What statins are fungal metabolites?
A
Lovastatin
Simvastati
Simvistatin
1
Q
What statin is liver friendly?
A
Pravastatin
No p 450 isoenzye 3a4
2
Q
What statins are synthetic
A
Atorvastatin Lipitor
Fluvastatin
Rosuvastatin
3
Q
What are the hydrophobic statins.
A
Pravastatin
Rosuvastatin
4
Q
What statin is hydrophobic?
A
Lovastatin
Simvastatin
Atorvastatin
5
Q
What does pleiotropic effects?
A
Non lipid lowering actions
6
Q
What are the pleiotropic effects of statins?
A
Vasodilation by NO eNoS Plaque stabalization Inhibition of thrombo genesis Attenuation of oxidative stress Reduction of inflammation IL 6 Blocks adhesion platelet aggregation
7
Q
Statin act on immune system by
A
Suppress T cell activation
monocytes, macrophage, fibroblasts
8
Q
What is special about simvastatin
A
Block free oxygen radicals
9
Q
What does statin do?
A
Converts acetoacetyl coA to mevalonic acid
10
Q
Main mechanism for pleiotropic effects of statin.
A
Iso pre noid intermediates inhibition
RAS rho system.
