Statins Flashcards
What are the main drugs in the statins class?
Atorvastatin, rosuvastatin, simvastatin, pravastatin, and fluvastatin
When is it recommended to take statins?
In the evening
Why should statins be taken in the evening?
Because your body makes most cholesterol at night
Which statins should be taken at night?
Pravastatin, simvastatin, and fluvastatin
Which statins can be taken at any time during the day?
Atorvastatin and rosuvastatin
What is the mechanism of action of statins?
Statins competitively inhibit HMG CoA reductase, reducing LDL-C levels
What does inhibition of HMG CoA reductase lead to?
Reduced production of cholesterol in the liver and increased removal of LDL-C from the blood
What is the effect of statins on cardiovascular disease risk?
They reduce the risk of cardiovascular disease, including myocardial infarction and stroke
What is the drug of choice for primary hypercholesterolaemia?
Statins
What condition is familial hypercholesterolaemia associated with?
High cholesterol concentration in the blood from birth due to an inherited genetic defect
What is the recommended statin treatment for familial hypercholesterolaemia?
Statins
What is the primary prevention recommendation for high-risk individuals for CVD?
High-intensity statin treatment (atorvastatin 20mg)
Who should receive atorvastatin 20mg for primary prevention?
People with a 10-year QRISK3 score of 10% or more, aged 85 and older, or adults with type 1 diabetes who meet specific criteria
What is the recommended statin treatment for secondary prevention of cardiovascular disease?
High-intensity statin treatment (atorvastatin 80mg)
What conditions qualify for secondary prevention with statins?
Established CVD, including history of myocardial infarction, angina, stroke, transient ischemic attack, or peripheral arterial disease
