Staphylococci

Question 1

Are staph spore-forming?

Answer 1

No

Question 2

S. epidermis is the most _______, inhabitant of the ______, foreign body infection due to ______ formation. Example is ______

Answer 2

ubiquitous; skin; exopolysaccharide; medical devices

Question 3

S. saprophyticus creates ______ ______ infections; commensal of ______ ______

Answer 3

urinary tract; GI tract

Question 4

S. aureus is the most ______

Answer 4

pathogenic

Question 5

S. aureus is found in the ______ ______ of 30% of people. Also found in ______, ______, ______

Answer 5

external nares; skin; oropharynx; feces

Question 6

S. aureus spreads from person-to-person through ______ and ______ contact, as well as ______

Answer 6

skin; mucus; aerosols

Question 7

S. aureus can be ______ ______, but is a particularly important nocosomial infection

Answer 7

community-acquired

Question 8

S. aureus promotes binding to ______ ______ proteins

Answer 8

extracellular matrix

Question 9

S. aureus secretes these factors:

1. ______
2. ______
3. ______
4. ______
5. ______

Answer 9

1. coagulase
2. Protein A
3. Catalase
4. Pore-forming toxins
5. Superantigens

Question 10

Coagulase

Answer 10

converts fibrinogen to fibrin, producing a fibrin capsule that impedes penetration of white blood cells

Question 11

Protein A

Answer 11

binds the Fc (opsonizing) portion of IgG

Question 12

Catalase

Answer 12

converts hydrogen peroxide to O2 + H2O and diminishes neutrophil killing

Question 13

Specific syndromes of S. aureus (5)

Answer 13

Furuncles; carbuncles; impetigo; cellulitis; toxigenic syndromes

Question 14

Scalded skin syndrome

Answer 14

exfoliative toxin. not necessarily the site where the focus of infection is. just where the toxin is working

Question 15

Toxic shock syndrome

Answer 15

superantigen illicit cytokine storm

Question 16

Acute food poisoning

Answer 16

staphylococcus enterotoxin

Question 17

S. aureus is a PAMPs and initiates an ______ immune response

Answer 17

innate

Question 18

S. aureus is a gram ______ ______ in ______

Answer 18

positive; cocci; clusters

Question 19

S. aureus colony color is ______

Answer 19

bronze/golden

Question 20

S. aureus has a vaccine: T/F

Answer 20

False

Question 21

S. aureus requires drainage: T/F

Answer 21

True, permit access of abx to site of infection

Question 22

S.aureus abx: ______, oxacillin, ______.

Answer 22

methicillin; nafcillin.

Question 23

S. aureus can be treated with penicillin: T/F

Answer 23

False!

Question 24

S. aureus when treated with methicillin can lead to ______

Answer 24

MRSA (methicillin-resistant staph aureus)

Question 25

S. aureus’s last line of abx drug is ______

Answer 25

Vancomycin