Staphylococci

Question 1

Staphylococci; description

Answer 1

GPC in clusters, catalase +ve

Question 2

Coagulase +ve Staphs?

Answer 2

Staph aureus

Question 3

How to test for coagulase?

Answer 3

Tube coagulase test

Question 4

Staph. aureus; vir. factors

Answer 4

cell wall – protein A; extracell. – enz and toxins

Question 5

Staph. aureus toxins

Answer 5

Alpha; entero-; TSST-1; epidermolytic

Question 6

Which outbreak in USA associated w/ hyperabsorbent tampons?

Answer 6

A TSST-1-producing Staph aureus

Question 7

TSST-1 not an superantigen?

Answer 7

F

Question 8

SSSS mediated by which toxin of which microbe?

Answer 8

Staph aureus that produces epidermolytic toxins

Question 9

Tx of Staph aureus inf?

Answer 9

(1) surgical drainage & debridement; (2) 1st line = cloxacillin (or other B-lactams) & 2nd line = erythromycin; (3) topical such as mupirocin

Question 10

Gene that contributes MRSA’s R?

Answer 10

mecA

Question 11

Which classes of ABx is MRSA R to?

Answer 11

B-lactams; penicillins + cephalosporins + carbapenems

Question 12

MRSA S to?

Answer 12

Ceftaroline/ ceftobiprole

Question 13

Empirical Tx of HAI of MRSA?

Answer 13

Vancomycin

Question 14

Severe Staph aureus infs leads to?

Answer 14

Septic arthritis; osteomyelitis; bac endocarditis; staph pneumonia (generally post-influenza); abscesses; TSS; SSSS

Question 15

Which other Staph like Staph aureus?

Answer 15

Staph lugdunensis! Chk for endocard

Question 16

Are CNS usually R to vancomycin?

Answer 16

No

Question 17

Line-associated infections most common microbe?

Answer 17

Often Staph aureus, CNS common

Question 18

Staph aureus causing line-associated inf particularly serious?

Answer 18

T

Question 19

Line-assoc inf w/ staph aureus require only short ABx Tx?

Answer 19

F

Question 20

staph pneumonia usually ____

Answer 20

occurs aft influenza inf