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Dermpath > Staining > Flashcards

Staining Flashcards

1
Q

Cytokeratin

A

Normal: epidermis and adnexal epithelium
Useful: SCC

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2
Q

S-100 protien

A

Normal: melanocytes, Langerhans, eccrine glands, chondrocytes, adipose tissu, nerves
Use: melanoma, adnexal tumors, neural tumors

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3
Q

HMB-45

A

Normal: melanocytes
Useful: some melanomas, nevi

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4
Q

MelanA/MART-1

A

Normal: melanocytes
Use: melanomas, some nevi

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5
Q

Mel-5

A

Normal: melanocytes

Useful for: some melanomas/nevi, vitiligo

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6
Q

Vimentin

A

Normal: tissue with mesenchymal derivation
Use: AFX, sarcomas, melanomas, some SCCs

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7
Q

Desmin

A

Normal: smooth/skeletal muscle
Use: muscle tumors

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8
Q

Smooth muscle actin (SMA)

A

Normal: smooth muscle, myofibroblastic cells
Use: smooth muscle tumors, some AFXs

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9
Q

Carcinoembryonic antigen (CEA)

A

Normal: eccrine/apocrine glands
Use: Adnexal tumors, Paget’s of the breast, fibroxanthomas

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10
Q

Epithelial membrane antigen (EMA)

A

Normal: sebacerous, eccrine, apocrine glands
Use: sebaceous tumors, SCC, epitheliod sarcoma, anaplastic large cell lymphoma

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11
Q

Neuron-specific enolase (NSE)

A

Normal: non-specific neuroendocrine marker
Use: Merkel

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12
Q

Chromogranin

A

Normal: neuroendocrine cells
Use: Merkel

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13
Q

Synaptophysin

A

Normal: neuroendocrine cells
Use: Merkel

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14
Q

Cytokeratin 20

A

Normal: neuroendocrine cells
Use: Merkel, trichoepithelioma

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15
Q

Fctor VII-related antigen

A

Normal: endothelial cells, platelets, megakaryocytes
Use: Vascular tumors

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16
Q

CD34

A

Normal: endothelial cells, stem cells
Use: DFSP, vascular tumors

17
Q

Factor XIIIa

A

Normal: dermal dendrocytes
Use: DF

18
Q

Cytokeratin 6/5, p63

A

Normal: epithelial cells

P63 use for: primary cutaneous adnexal tumors, negative in metastatic adenocarcinomas

19
Q

TTF-1

A

Normal: thyroid tissue
Use: lung carcinoma, negative in Merkel

20
Q

Adipophilin

A

Use: sebaceous carcinoma

Dermpath (3 decks)

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