Stable & Vasospastic Angina Pharmacology

Question 1

Suffix for Nitrates

Answer 1

Nitrate

Isosorbide dinitrate
Isosorbide mononitrate
Nitroglycerin

Question 2

Suffix for non-cardiovascular (dihydropyridines) calcium channel blockers

Answer 2

Dipine

Amlodipine
Nifedipine
Nicardipine

Question 3

Suffix for Beta-blockers

Answer 3

Olol

Propranolol
Nadolol
Metroprolol
Atenolol

Question 4

What are the cardioactive calcium channel blockers used to treat stable angina & vasospatic angina

Answer 4

Diltiazem

Verapamil

Question 5

What are the drug classes used to treat stable angina and vasospastic angina

Answer 5

Nitrates
Calcium channel blockers
Beta blockers
Ranolazine

Question 6

Nitrates interact with drugs used in erectile dysfunction which can cause a dramatic drop in BP and acute MI. What is the suffix of these drugs

Answer 6

-afil

Sildenafil
Vardenafil
Tadalafil

Question 7

What is the mechanism of action of Nitrates, Beta blockers & calcium channel blockers in the treatment of stable angina

Answer 7

Decrease myocardial oxygen demand

Question 8

What drug is used in angina refractory to other medical therapies

Answer 8

Ranolazine

Question 9

What is the MOA of Ranolazine

Answer 9

Inhibits the late phase inward sodium current thereby reducing diastolic wall tension and oxygen consumption. Does not affect heart rate or blood pressure

Question 10

What is the best treatment for stable angina

Answer 10

Combination therapy: Nitrates w/ beta blockers or calcium channel blockers

Question 11

What is the first choice of drugs for treating vasospastic angina

If 1st choice is contraindicated, what is the next choice?

Answer 11

CCB - Amlodipine or Diltiazem

Long-acting nitrates (less desirable due to occurrence of tolerance but can be added to CCBs to improve efficacy)