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Pathology images > St Adrenals and Paragangliomas > Flashcards

St Adrenals and Paragangliomas Flashcards

1
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Fetal adrenal with primitive sympathetic cells forming neuroblastic nodules

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2
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Newborn adrenal with focal cytomegaly of fetal cortex

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3
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Newborn adrenal of Beckwith-Wiedemann syndrome with widespread cytomegaly

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4
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Atrophic adrenal gland:

  • fibrotic capsule and cortical layer is atrophic but medulla unaffected.

DDx adrenal hypofuntion:

  • _atrophic:_autoimmune (lymphocytes and plasma cells, abs sto P450 enzyme), Type I polyglandular autoimmune sydrnome (APECED, AR), Type II polyglandular autoimmune syndrome (AD), previous Waterhouse-Friderichsen (fibrosis), exogenous corticosteroid, Cushing syndrome
  • necrotic: CMV
  • replacement: TB (caseous), fungus (caseous), Amyloidosis, tumour, Waterhouse-Friderichsen (blood), anticoagulatn tx (blood)
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5
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Adrenocortical hyperplasia

  • vacuolated fasciculata
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6
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Primary hyperaldosteronism

  • Hyperplasia of zona glomerulosa
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7
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Primary pigmented nodular adrenocortical disease - microadenomatous hyperplasia:

  • Nodules of large, granular eosinophilic cells with enlargec hyperchromatic nuclei with prominent nucleoli
  • filled with lipochrome
  • associated with Carney complex (PRKAR1A)
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8
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Pigmented (black) adrenocortical adenoma

  • associated with Cushing syndrome
  • compact cells with lipochrome pigment
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9
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Adrenocortical adenoma with stromal fibrosis

  • associated with Cushing syndrome
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10
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Adrenocortical adenoma, myelolipomatous change

  • Associated with Cushing syndrome
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11
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Adrenocortical carcinoma

  • areas of necrosis
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12
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Adrenocortical carcinoma

  • marked nuclear pleomorphism
  • intranuclear pseudoinclusions
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13
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Adrenal cyst, endothelial type (+ Factor VIII)

  • other types: epithelial, parasitic, endothelial and psuedocysts
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14
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Adrenal myelolipoma

  • hematopoeitic tissue scattered among fat
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15
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Metastatic pulmonary adenocarcinoma

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16
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Adrenal gland with metastatic bronchogenic adenocarcinoma, FNA

17
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Adrenocortical hemangioma

18
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Adenomatoid tumour

  • glands and tubules
  • +: calretinin and CK
19
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Ganglioneuroma

20
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Pheochromocytoma

21
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Pheochromocytoma

  • +: Chromogranin A
22
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Diffuse hyperplasia of adrenal medulla

  • anisonucleosis of cells expected
23
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Pheochromocytoma, S100+ sustentacular cells

Pathology images (4 decks)

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