SSRI's, MAOI's, TCA's, Atypicals

Question 1

What can you take with Fluoxetine to help with sexual dysfunction?

Answer 1

Bupropion

Question 2

Name 2 MAO-A inhibitors and raise norepinephrine, epinephrine, serotonin, and tyramine, dopamine

Answer 2

Phenelzine, Tranylcypromine

Question 3

2x potency, all active form basic SSRI

Answer 3

Escitalopram

Question 4

SSRI’s inhibit (2)

Answer 4

P450, 5HT reuptake

Question 4

What will increase serum Lithium levels?

Answer 4

Diuretics, NSAIDs, ACE-inhibitors

Question 5

2 SSRI’s for PTSD

Answer 5

Fluvoxamine

Paroxetine

Question 6

Action of Bupropion

Answer 6

Reuptake inhibitors of DA

Question 9

Reversible inhibitor of MAO-A

Answer 9

Moclobemide

Question 10

Trade name of Fluoxetine

Answer 10

Prozac

Question 11

Irreversible MAO-B inhibiter: elevates dopamine and phenylethylamine and used in Parkinson’s

Answer 11

Selegiline

Question 13

TCA’s net effect

Answer 13

Elevate 5HT and NE transmission

Question 14

4 other receptors blocked by TCA’s

Answer 14

Sodium channels
Histamine-1 receptor
Alpha-receptors
Muscarinic receptors

Question 15

DOC bipolar disorder

Answer 15

Lithium

Question 16

4 Indications for TCA’s

Answer 16

Major depression
Phobias, anxieties, OCD
Chronic pain disorders
Enuresis

Question 17

MAOI’s are used to treat:

Answer 17

Atypical depression (patient eats and sleeps a lot)

Question 18

Which basic SSRI doesn’t inhibit P450

Answer 18

Citalopram

Question 19

SSRI’s ______ CYP2D6 and will _______(increase/decrease) TCA levels

Answer 19

Inhibit CYP2D6

Increase TCA levels

Question 20

4 notable adverse effects of Lithium

Answer 20

Polyuria/polydipsia
Ataxia
Goiter; Hypothyroidism
Weight gain

Question 21

You should wait _______days to switch from prescribing a TCA to SSRI’s

Answer 21

14 days

Question 23

Trade name of Paroxetine

Answer 23

Paxil

Question 24

2 specific norepinephrine reuptake inhibitors

Answer 24

Maprotiline and Reboxitine

Question 26

Trade name of Escitalopram

Answer 26

Lexapro

Question 27

Half life of Fluoxetine’s metabolites

Answer 27

10 days

Question 28

Some patients experience an increase in anxiety or agitation during early treatment of this SSRI.

Answer 28

Fluoxetine

Question 30

Noradrenergic/Specific serotonergic antidepressant

Answer 30

Mirtazapine

Question 31

(2) Serotonin 5HT2, 5HT7 antagonists/reuptake inhibitors

Answer 31

Trazodone and Nefazodone

Question 32

2nd line drug for patients who cannot tolerate Lithium is:

Answer 32

Carbamazepine

Question 33

Half life of lithium

Answer 33

20 hours

Question 34

Venlafaxine elevates synaptic levels of:

Answer 34

NE and serotonin

Question 35

3 drugs with selective blockade of NET and SERT

Answer 35

Venlafaxine
Desvenlafaxine
Duloxetine

Question 36

Lithium inhibits recycling of

Answer 36

Inhibits recycling of neuronal membrane phosphoinositides

Question 38

Trade name of Citalopram

Answer 38

Celexa

Question 39

Lithium MOA:

Answer 39

Blocks 5-monophosphatase. Alters Na transport; decreases inositol (Gq not active)