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210 SSRI’s > SSRI’S > Flashcards

SSRI’S Flashcards

1
Q

Ssri’s

A

Selectively reuptate serotonin in the synaptic space. Thereby intensify the effects of serotonin

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2
Q

Ssri’s

A

First line of pharmacological treatment for depression - months to show benefit months to show full therapeutic effect

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3
Q

Ssri’s

A

May increase the level of energy before mood.

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4
Q

Ssri’s side effects

A

Nausea, vomiting, diarrhea, weight loss, headache, sexual dysfunction (erectile disfunction ,sexual desire, difficulty reaching orgasm)

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5
Q

Ssri increase the risk for bleeding if they are taken with what medication?

A

NSAID’s, aspirin, warfarin, and other blood thinners

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6
Q

Ssri’s approved by FDA to treat
depression?

A
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7
Q

CITALOPRAN

A

CELEXA

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8
Q

ESCITALOPRAM

A

LEXAPRO

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9
Q

FLUOXETINE

A

PROZAC

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10
Q

PAROXETINE

A

PAXIL - PEXEBA

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11
Q

SERTRALINE

A

ZOLOFT

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12
Q

SNRI’S

A

Selectively block the uptake ofNOREPINEPHRINE and SERATONIN, intensifying the effect of neurotransmitters

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13
Q

WHAT ARE THE SIDE EFFECTS OF SNRI’S?

A

Nausea, sweating, insomnia, tremors, sexual dysfunction

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14
Q

SNRI’S approved by the FDA

A
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15
Q

DESVENLAFAXINE

A

PRISTIQ

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16
Q

DULOXETINE

A

CYMBALTA (also used for anxiety and chronic pain)

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17
Q

LEVOMILNACIPRAN

A

FETZIMA

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18
Q

VENLAFAXINE

A

EFFEXOR XR- also approved to treat certain anxiety and panic disorders

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19
Q

ATYPICAL ANTIDEPRESSANTS

A

Change levels of 1 or more neurotransmitters.
Dopamine
SERATONIN
Norepinephrine

20
Q

ATYPICAL ANTIDEPRESSANTS APPROVED BY THE FDA

A
21
Q

BUPROPION.

A

Low risk for sexual dysfunctions, and weight gain, lower threshold of seizures. Not recommended for ppl with history of head injury , seizure or eating disorder-

Wellbutrin SR,
-Wellbutrin XL
- Nefazodone
-Trazodone

22
Q

VILAZODONE

A

Viibryd

23
Q

VORTIOXETINE

A

Trintellix

24
Q

MIRTAZAPINE

A

Increases appetite
—Beneficial for those with low intake
-weight gain
- fatigue
-elevated cholesterol

25
Q

TRAZODONE

A

In combination with SSRI treats insomnia, side effects of sedation are rare( prolonged erection of penis)

26
Q

TRICYCLIC ANTIDEPRESSANTS - TCAs

A
27
Q

Adverse effects of TCA’S

A

Anticholinergic effects
-orthostatic hypotansion
-sedation
-arrhythmia
-tachycardia
Lethal toxicity - OD
- Excessive sweating
-Increase appetite/ weight gain
- Sexual dysfunction

28
Q

TCA’S are CONTRAINDICATED/ PRECAUTIONS for:

A
  • Seizure disorder
    -CAD
    -Diabetes
  • Urinary retention
    -HIGHLY TOXIC, ASSESS OD
  • MAY INCREASE SUICIDE RISK
29
Q

TCA’S approved by the FDA

A
30
Q

AMYTRIPTYLINE

A
31
Q

AMOXAPINE

A
32
Q

DESIPRAMINE

A

NORPRAMIN

33
Q

DOXEPIN

A
34
Q

NORTRIPTYLINE

A

Pamelor

35
Q

TCA’S treat……

A

-Depression
- OCD
- Anxiety
- Neuropathy

36
Q

WHEN TO TAKE TCA’S ?

A

At bed time because of drowsiness

37
Q

TCA’S that cause weight gain

A

-amitryptyline
-doxepin
-I I-famine
-trimipramine

38
Q

WHAT TCA’S ARE MORE TOLERATED

A

-NORTRYPTYLINE
-DESIPRAMINE

39
Q

MONOAMINE OXIDASE INHIBITORS (MAOI’s)

A

Increases :

Norepinephrine
-dopamin
-SERATONIN

40
Q

WHAT ARE THE RISKS FOR MAOI’s

A

Hypertensive crisis
-Orthostatic Hypotension
- Require a 14 day washout

41
Q

TCA’S interactions and contraindications

A

-SSRI’s
-TCA’S
-SSRI’s
-OTC decongestants
-Antihypertensive
- Amphetamines and caffeine
- HF and CVD
- Renal disease, pheochromocytoma, irregular secretion of epinephrine and norepinephrine
- IncreasesBP, palpitations and HA

42
Q

MAOI’S APPROVED BY THE FDA

A
43
Q

ISOCARBOXACID

A

MARPLAN

44
Q

PHENELZINE

A

Nardil

45
Q

SELEGILINE

A

Emsam

46
Q

TRANYLCYPROMINE

A

PARNATE

47
Q

ALL ANTIDEPRESSANTS CARRY A BLACK BOX WARNING FOR INCREASE RISK OF SUICIDE IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS SPECIALLY THE FIRST FEW WEEKS AFTER STARING , OR WHEN THE DOSE HAS CHANGED.

A

210 SSRI’s (1 decks)

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