SSRI’S Flashcards
Ssri’s
Selectively reuptate serotonin in the synaptic space. Thereby intensify the effects of serotonin
Ssri’s
First line of pharmacological treatment for depression - months to show benefit months to show full therapeutic effect
Ssri’s
May increase the level of energy before mood.
Ssri’s side effects
Nausea, vomiting, diarrhea, weight loss, headache, sexual dysfunction (erectile disfunction ,sexual desire, difficulty reaching orgasm)
Ssri increase the risk for bleeding if they are taken with what medication?
NSAID’s, aspirin, warfarin, and other blood thinners
Ssri’s approved by FDA to treat
depression?
CITALOPRAN
CELEXA
ESCITALOPRAM
LEXAPRO
FLUOXETINE
PROZAC
PAROXETINE
PAXIL - PEXEBA
SERTRALINE
ZOLOFT
SNRI’S
Selectively block the uptake ofNOREPINEPHRINE and SERATONIN, intensifying the effect of neurotransmitters
WHAT ARE THE SIDE EFFECTS OF SNRI’S?
Nausea, sweating, insomnia, tremors, sexual dysfunction
SNRI’S approved by the FDA
DESVENLAFAXINE
PRISTIQ
DULOXETINE
CYMBALTA (also used for anxiety and chronic pain)
LEVOMILNACIPRAN
FETZIMA
VENLAFAXINE
EFFEXOR XR- also approved to treat certain anxiety and panic disorders
ATYPICAL ANTIDEPRESSANTS
Change levels of 1 or more neurotransmitters.
Dopamine
SERATONIN
Norepinephrine
ATYPICAL ANTIDEPRESSANTS APPROVED BY THE FDA
BUPROPION.
Low risk for sexual dysfunctions, and weight gain, lower threshold of seizures. Not recommended for ppl with history of head injury , seizure or eating disorder-
Wellbutrin SR,
-Wellbutrin XL
- Nefazodone
-Trazodone
VILAZODONE
Viibryd
VORTIOXETINE
Trintellix
MIRTAZAPINE
Increases appetite
—Beneficial for those with low intake
-weight gain
- fatigue
-elevated cholesterol
TRAZODONE
In combination with SSRI treats insomnia, side effects of sedation are rare( prolonged erection of penis)
TRICYCLIC ANTIDEPRESSANTS - TCAs
Adverse effects of TCA’S
Anticholinergic effects
-orthostatic hypotansion
-sedation
-arrhythmia
-tachycardia
Lethal toxicity - OD
- Excessive sweating
-Increase appetite/ weight gain
- Sexual dysfunction
TCA’S are CONTRAINDICATED/ PRECAUTIONS for:
- Seizure disorder
-CAD
-Diabetes - Urinary retention
-HIGHLY TOXIC, ASSESS OD - MAY INCREASE SUICIDE RISK
TCA’S approved by the FDA
AMYTRIPTYLINE
AMOXAPINE
DESIPRAMINE
NORPRAMIN
DOXEPIN
NORTRIPTYLINE
Pamelor
TCA’S treat……
-Depression
- OCD
- Anxiety
- Neuropathy
WHEN TO TAKE TCA’S ?
At bed time because of drowsiness
TCA’S that cause weight gain
-amitryptyline
-doxepin
-I I-famine
-trimipramine
WHAT TCA’S ARE MORE TOLERATED
-NORTRYPTYLINE
-DESIPRAMINE
MONOAMINE OXIDASE INHIBITORS (MAOI’s)
Increases :
Norepinephrine
-dopamin
-SERATONIN
WHAT ARE THE RISKS FOR MAOI’s
Hypertensive crisis
-Orthostatic Hypotension
- Require a 14 day washout
TCA’S interactions and contraindications
-SSRI’s
-TCA’S
-SSRI’s
-OTC decongestants
-Antihypertensive
- Amphetamines and caffeine
- HF and CVD
- Renal disease, pheochromocytoma, irregular secretion of epinephrine and norepinephrine
- IncreasesBP, palpitations and HA
MAOI’S APPROVED BY THE FDA
ISOCARBOXACID
MARPLAN
PHENELZINE
Nardil
SELEGILINE
Emsam
TRANYLCYPROMINE
PARNATE
ALL ANTIDEPRESSANTS CARRY A BLACK BOX WARNING FOR INCREASE RISK OF SUICIDE IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS SPECIALLY THE FIRST FEW WEEKS AFTER STARING , OR WHEN THE DOSE HAS CHANGED.
