SSRI and SNRI Flashcards
List all SSRIs
Fluoxetine (Prozac)
Paroxetine (Paxil)
Sertraline (Zoloft)
Citalopram (Celexa)
Escitalopram (Lexapro)
Fluvoxamine (Luvox)
Fluoxetine Positives and Negatives
Positives- long half life (no need to taper, no d/c symptoms, better for ? Compliance)
Negative- drug interactions (2D6 metabolism), apathy at a higher dose
Paroxetine positives and negatives
Positive- sedating (use in place of benzo)
Negative- short half life (discontinuation symptoms), sedating, pregnancy SEs ( persistent plum htn)
Sertraline positives and negatives
Positives- low pregnancy side effects, large dosage range, small doses for SAD
Negatives- more nausea, shorter acting
Citalopram positives and negatives
Positives- longer half life
Negatives- QTc prolongation over 40 mg, more weight gain and sedation
Escitalopram positives and negatives
Positives- fewer drug drug interactions, weight neutral
Negatives- shorter acting, nausea and vomiting
Fluvoxamine positives and negatives
Positives- OCD!!! Anxiety in kids
Negatives- not responsive for depression
Side effects of SSRIs
Nausea- transient
Sexual side effects (delayed ejaculation) perpetuating
Weight gain
Platelet dysfunction
SSRIs okay in renal disease
Prozac, Paxil, Lexapro
SSRIs okay in liver disease
Prozac and Lexapro
List SNRIs
Duloxetine (Cymbalta)
Venlafaxine (Effexor)
Fetzima
Duloxetine positives and negatives
Positives- neuropathic pain
Negatives- hypertension
Venlafaxine positives and negatives
Positives- none?
Negatives- hypertension, lower dose is serotonergic and higher dose is adrenergic
Fetzima qualities
More adrenergic than serotonergic
SSRIs for PTSD
Sertraline, paroxetine, venlafaxine (gaining evidence)
Prazosin— nightmares
