Spondyloarthropathy

Question 1

The gut wall is a leaky barrier exposed to what?

Answer 1

Commensal and pathologic microorganisms

Question 2

Microbiota are essential for what in the immune system?

Answer 2

Maturation and regulation

Question 3

GI Lymphoid tissue-microbiota interaction balances between what?

Answer 3

Inflammatory defense and tolerance

Question 4

Genetic polymorphisms in Crohn’s dz can result in?

Answer 4

Relative immune deficiency

Question 5

Some types of joint dz in inflammatory bowel dz are determined by what?

Answer 5

Genetics

Question 6

What interacts with non-major histocompatibility genes?

Answer 6

HLA-B27

Question 7

Celiac dz is common in adults, 25% of those patients will have what?

Answer 7

Joint manifestation

Question 8

Patients with Whipples often present with?

Answer 8

Joint symptoms

Question 9

Microscopic colitis is accompanied with?

Answer 9

Extraenteric AI manifestations

Question 10

Psoriatic arthritis should be suspected in a patient who?

Answer 10

Has an asymmetric joint distribution pattern who may have addition clinical features such as dactylitis, enethesitis, or inflammatory type back pain, and who is negative for RH factor

Question 11

What are the new classification criteria for Psoriatic arthritis? (generally speaking)

Answer 11

the Classification of Psoriatic Arthritis (CASPAR)

Question 12

Psoriatic arthritis is a progressive dz, with 47% developing what within 2 years and what is a poor marker of the dz?

Answer 12

Developing erosions, and polyarticular dz and an elevated ESR

Question 13

An essential core set of domains and instruments is not agreed as being necessary for inclusion in what?

Answer 13

Clinical trials (had to make it a question somehow)

Question 14

Studies of synovial tissue have highlighted an increase in what? What is the outcome of this?

Answer 14

Increase in vascularity and presence of neutrophils to help distinguish spondyloarthropathy from RA

Question 15

What may change in synovial CD3+ T cell infiltration correlate with?

Answer 15

Clinical response to treatment

Question 16

Prominent entheseal involvement with bone marrow edema at entheseal insertions on MRI has prompted what hypothesis?

Answer 16

That psoriatic arthritis may originate at the enthesis

Question 17

A role for what has been proposed in psoriatic arthritis? (immune system related)

Answer 17

CD8+ T cells and the innate immune response

Question 18

Although there is a paucity of evidence for efficacy of disease-modifying antirheumatic drugs in psoriatic arthritis, what is effective for skin and joint dz?

Answer 18

TNF inhibitors