splitsingscondities

Question 1

merrifield resin

Answer 1

HF

Question 2

wang resin

Answer 2

95% TFA

Question 3

sasrin resin

Answer 3

1% TFA

Question 4

HAL resin

Answer 4

0,1% TFA

Question 5

Rink-amide resin

Answer 5

10-50%TFA

Question 6

Rink-acid resin

Answer 6

0,2% TFA

Question 7

trityl resin

Answer 7

2%TFA

Question 8

2-chloro tritylresin

Answer 8

1% TFA

Question 9

nucelofiel: NaOH

Answer 9

carbonzure functie, hydrolyse

Question 10

nucelofiel: amine

Answer 10

amide functie, aminolyse

Question 11

nucelofiel: hydrazine

Answer 11

hydrazide , aminolyse

Question 12

nucelofiel: alcohol

Answer 12

ester , transesterificatie

Question 13

1- (9-hydroxymethyl)-fluorenyl resin

Answer 13

15% piperidine

Question 14

HMBA-AM resin

Answer 14

NaOH, methanol, NH3, hydrazine

Question 15

bromoacetyl resin

Answer 15

NaOH, amine, hydrazine

Question 16

1-bromoethyl-3-nitrophenyl resin

Answer 16

UV licht

Question 17

4-(2-aminoethyl)-2-methoxy-5nitrophenoxy resin

Answer 17

UV licht

Question 18

4-(2-hydroxyethyl)-2-methoxy-5nitrophenoxy resin

Answer 18

UV licht

Question 19

SCAL

Answer 19

1) reductie sulfoxide=> sulfide

2) zure afsplitsing TFA (benzhydril linker)

Question 20

Kenner’s resin

Answer 20

1) activatie van het sulfonamide met iodoacetonitrile (ICH2CN) of diazomethaan (CH2N2) tot een tert amide
2) amino( amine of OH) of hydrolyse met vorming van een amide of carbonzuur

Question 21

4-(4-hydroxymethyl-phenoxymethyl-dimethylsilyl-bromobenzeen resin

Answer 21

TFA, CsF (cesiumfluoride)

Question 22

4-metoxymethyl-oxyphenyl-diisopropyl-hydroxysilyl resin

Answer 22

TBAF

Question 23

Boc/Bn strategy

Answer 23

Boc=tert-butyloxycarbonyl =tijdelijke beschermgroep afsplitsing: 20% TFA
Bn= benzyl= permanente beschermgroep
afsplitsing: HF

Question 24

FMOC/tert-Bu

Answer 24

FMOC=fluorenylmethoxycarbonyl = tijdelijke bescherm
afsplitsing: piperidine (base)
tert-butyl= permanente beschermgroep
afsplitsing: 1%-95%TFA

Question 25

polysterin resin

Answer 25

lading: 0,5-1,6 mmol/g
splitsingcondities: HF, NaOH, THA
zwelling: DCM, DMF
krimpen: MeOH, water en Et2O
functionalisatie: aromatische substitutie

Question 26

tentagel resin

Answer 26

polysterin + PEO
lading: 0,1-0,4 mmol/g
zwelling: polaire en organische solventen
mech stabieler dan PS resin, maar chemisch minder stabiel
functionalisatie: aromatische substitutie

Question 27

pepsyn resin

Answer 27

polyamide resin
functionalisatie: via ester functie
zwelling: polaire aprotische solventen: DMF en NMP
lage mech stabiliteit

Question 28

pepsyn K

Answer 28

polyamide
functionalisatie: via ester functie
beter mech stabiliteit
beperkte zwelling => klein porie grootte=> kleine belading (0,1mmol/g)

Question 29

polyhipe

Answer 29

= tentagel met acrylamide ipv PEO, polyamide
functionalisatie:ester
zwelling in veel solventen
hoge belading (5mmol/g)

Question 30

PEGA resin

Answer 30

poly(acrylamide-ethyleenglycol) resin
hydrofiele matrix met amfifile eig
functionalisatie: via amine
hoge crosslinking+ sterke zwellling: water, alcohol, DCM en DMF
belading: 0,3-0,4 mmol/g

Question 31

chemmatrix

Answer 31

100% PEG-gebaseerde resin
belading:0,4-0,7 mmol/g
zwelling: polaire solventen: water, THF, DMF, methanol en acetonitrile
grote of hydrofobe peptide