Spirochetes Flashcards
Tertiary Syphilis characterised by appearance of?
chronic granulomas
If born alive, then the baby presents
with:
• Early congenital syphilis?
mucocutaneous lesions, osteochondritis,
anemia, and hepatosplenomegaly
If born alive, then the baby presents
with Late congenital syphilis
Interstitial keratitis •
Eighth-nerve deafness • Notched incisors
Laboratory diagnosis of syphilis
Direct methods
Specimen:Freshly collected exudates from
chancre in 1ry stage
»condylomas or ulcers in
2ry stag
Of Fontana Stained preparation By Light microscope
T.Pallidum appearance?
dark brown spiral organisms against yellowish background
False positive results: due to
formation
of reagins antibodies in a variety of diseases
What is the treatment that you use to treat primary and secondary sypilis
penicillin
It’s a systemic reaction due to rapid death
of treponemas and release of endotoxin-like
substance.
Jarisch-Herxheimer reaction
Patients with 3ry syphilis manifesting
with gummas or with cardiovascular are
treated with
3 doses of benzathine
penicillin G.
Patients with neurosyphilis receive high
dose of
intravenous aqueous penicillin G
as it crosses the BBB
Penicillin-allergic, nonpregnant patients
with early syphilis can be treated with
doxycycline
To prevent congenital syphilis, all
pregnant women should be screened by
using a treponemal test such as
FTA-ABS.
Nonvenereal Treponemal Diseases are transmitted by
direct contact