Spinal cord & ascending + descending pathways Flashcards

1
Q

Describe the relationship of the spinal cord and associated roots with the spinal canal and meninges

A

Anterior + posterior rootlets -> anterior and posterior root -> roots pass through subarachnoid space until they reach the appropriate intervertebral foramina -> as they pass through the foramina the posterior root is enlarged by the posterior root ganlgion -> roots fuse to form mixed spinal nerve -> anterior and posterior rami

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2
Q

What is the spinal cord called when it terminates?

A

Conus medullaris which in turn continues as a thin connective tissue cord called the filum terminale which is anchored to the dorsum of the coccyx

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3
Q

Where do the spinal cord and filum terminale end respectively?

A

L2 & S2

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4
Q

What structure anchors the spinal cord in the spinal canal?

A

The denticulate ligament suspends the lateral aspects of the spinal cord in the canal

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5
Q

What is the denitculate ligament composed of?

A

Pial and arachnoid tissue and attaches to the dura at various points along the length of the cord

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6
Q

At which spinal segments is there an additional lateral horn in the grey matter?

A

Levels T1-L2. The lateral horn contains preganglionic sympathetic neurons

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7
Q

Describe the central canal of the spinal cord

A

The central canal is small and runs the entire length of the spinal cord. Rostrally it opens into the 4th ventricle and caudally it is blind ending

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8
Q

Name the 3 types of artery that supply the spinal cord

A

Longitudinal (x3), segmental and radicular

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9
Q

Describe the longitudinal arteries of the spinal cord

A

3 major arteries - one anterior and 2 posterior that all originate from the vertebral arteries. These run the length of the spinal cord

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10
Q

Describe the segmental arteries of the spinal cord

A

Derived from vertebral, intercostal and lumbar arteries

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11
Q

Describe the radicular arteries of the spinal cord

A

Travel along the dorsal and ventral roots

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12
Q

Describe the venous drainage of the spinal cord

A

Similar to arterial supply with both longitudinal and segmental veins

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13
Q

How does the dura in the cranial cavity differ from that in the spinal canal?

A

In the cranial cavity the dura is directly attached to the periosteum whereas in the spinal canal there is a space between the dura and the bone, the epidural space, which contains adipose tissue and the anterior and posterior epidural venous plexuses. This space is utilised in epidural anaesthesia

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14
Q

Where is the primary somatosensory cortex?

A

Post-central gyrus

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15
Q

Sensory fibres cross the midline of the brain - what does this mean?

A

It means that the left side of the body is represented on the right cortex and vice versa

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16
Q

In which regions is the spinal cord larger?

A

Cervical and lumbar

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17
Q

What happens to white matter as you descend the spinal cord?

A

White matter occupies a smaller proportion of the cord as you descend

18
Q

What is the function of the dorsal column/medial lemniscus (DCML)?

A

Fine touch and conscious proprioception - particularly in the upper limb

19
Q

Where do the fibres of the DCML cross?

A

Medulla oblongata

20
Q

What is the function of the spinothalamic tract?

A

Pain, temperature and deep pressure

21
Q

Where do the fibres of the spinothalamic tract cross?

A

They cross segmentally!

22
Q

Where do the fibres of the DCML synapse?

A

Thalamus

23
Q

Where do the fibres of the spinothalamic tract synapse?

A

Thalamus

24
Q

Where is the primary motor cortex located?

A

Precentral gyrus

25
Q

The motor function on the left side of the body is controlled by the left side of the brain (T/F)

A

False - the motor fibres cross the midline thus the right cortex controls muscles on the left side of the body and vice versa

26
Q

What is the function of the corticospinal tract?

A

Fine, precise movement particularly of distal limb movements e.g. digits

27
Q

Why is the corticospinal tract also referred to as the pyramidal tract?

A

The tract forms visible ridges referred to as the pyramids on the anterior surface of the medulla

28
Q

Where do the corticospinal/pyramidal tract fibres cross?

A

About 85% of fibres cross in the caudal medulla at the decussation of the pyramids

29
Q

What do crossed and uncrossed fibres form?

A

Crossed fibres form the lateral CST and uncrossed fibres form the ventral CST. The ventral CST fibres cross segmentally

30
Q

What can happen as a result of CVA of the internal capsule?

A

Can result in a lack of descending control of the corticospinal tract which results in a spastic paralysis with hyperflexion of the upper limbs. This is sometimes referred to as decorticate posturing

31
Q

Name 3 extrapyramidal tracts

A

Tectospinal, reticulospinal and vestibulospinal

32
Q

What is the function of the tectospinal tract?

A

Thought to mediate reflex head and neck movements in response to visual stimuli

33
Q

What is the function of the reticulospinal tract?

A

Influences voluntary movement

34
Q

Where is the reticulospinal tract found?

A

Reticular formation forms the central core of the brainstem. It has many nuclei and receives input from virtually all parts of the CNS

35
Q

Where do the fibres of the reticulospinal tract originate?

A

Fibres originate in areas of the reticular formation in pons and medulla

36
Q

How does the function of the reticulospinal tract differ depending on where the fibres come from i.e. from pons or medulla?

A

Fibres originating in pons facilitate extensor movements and inhibit flexor movements, while those originating in the medulla do the opposite

37
Q

Where do fibres from the vestibulospinal tract originate?

A

Fibres originate in the vestibular nuclei of pons and medulla (these in turn receive input from vestibular apparatus and cerebellum).

38
Q

What is the function of the vestibulospinal tract?

A

Excitatory input to “antigravity” extensor muscles

39
Q

Which spinal tract is thought to play an important role in patients exhibiting decerebrate rigidity and paraplegia in extension?

A

The vestibulospinal tract

40
Q

What can happen as a result of a brainstem injury at the level of the midbrain?

A

Lesions of the brainstem at the level of the midbrain can result in a lack of descending cortical control of the vestibulospinal tract (plus others). This leads to domination of extensor muscle tone and hyperextended spastic paralysis

41
Q

What is the other name given to a lateral hemi-section of the spinal cord and what would be the clincial consequenes of this injury?

A

Brown-Sequard’s syndrome - ipsilateral paralysis, ipsilateral hyperreflexia & extensor plantar reflex, ipsilateral loss of vibratory sense and proprioception + contralateral loss of pain and temperature sense