Specification Of Cell Fates part 1 Flashcards
What are the three classes of adhesion molecules?
- Cadherins
- immunoglobulin superfamily
- intergrins
How do cadherins work?
In the presence of calcium ions they adhere to cadherins on another cell surface
Describe the immunoglobulin superfamily
These are calcium ion independent (ca2+).
Some of its members bind to similar molecules on other cells,
some bind to intergrins
What are intergrins?
They act as receptors for molecules of the extracellular matrix.
They mediate adhesion between a cell and its substratum
What are catenins?
The intracellular part of an adherent junction.
Where are cadherins found?
They span the membrane and into the extracellular space, in adherins junctions and desmosomes
What are CAMs?
Cell adhesion molecules
What is the other role of cadherins?
They interact with catenins, which interact with the intracellular cytoskeleton. Thus they are involved in transmitting signals to the cytoskeleton.
What is meant by ‘cell behaviour’
- patterns of growth
- patterns of division
- patterns of movement
Everything that converts an egg to an organism
What do and don’t fate maps show?
Do:
- show Where tissues come from
- show changes in cell behaviour
Not:
- tell us about states of determination
- the full potential of each embryonic region
What does ‘state of determination mean’?
Is it pre determined? Is it influence by its environment?
