Specific Polyneuropathies

Question 1

2 mixed axonal and demyelinating neuropathies

Answer 1

Diabetes and uremia

Question 2

Nerve biopsy finding of leprosy

Answer 2

Foamy histiocyte invasion

Question 3

3 different uniform demyelinating mixed sensorimotor neuropathies

Answer 3

HMSN I, III, IV

Question 4

Which axonal sensorimotor neuropathy causes uveitis

Answer 4

Sarcoidosis

Question 5

What kind of neuropathy is multifocal motor neuropathy

Answer 5

Demyelinating motor neuropathy

Question 6

What distinguishes HMSN II from the other ones?

Answer 6

Less foot intrinsic involvement.

Question 7

3 segmental demyelinating motor and sensory neuropathies

Answer 7

AIDP (GBS), CIDP, leprosy (Hansen’s disease)

Question 8

What would CSF analysis show for HMSN I, III, IV?

Answer 8

Increased protein

Question 9

Is weakness in CIDP more proximal or distal

Answer 9

Proximal

Question 10

Which axonal sensorimotor neuropathy has foot or wrist drop

Answer 10

EtOH

Question 11

Which toxin causes blue lines in gums

Answer 11

Lead

Question 12

What would nerve biopsy show for HMSN I, III, IV

Answer 12

Onion bulb formation

Question 13

Which axonal sensory neuropathy results in nephrotoxicity

Answer 13

Cis-platinum toxicity

Question 14

3 axonal sensorimotor neuropathies

Answer 14

EtOH, amyloidosis, sarcoidosis

Question 15

Which toxin causes lower limb weakness

Answer 15

Vincristine

Question 16

3 main toxins that lead to neuropathy

Answer 16

Lead, vincristine, dapsone

Question 17

4 axonal sensory neuropathies

Answer 17

Cis-platinum toxicity, friedreich’s ataxia, sjogren’s, Vit b6 toxicity

Question 18

Most common CN affected in AIDP

Answer 18

CN 7

Question 19

Which axonal sensory neuropathy results in WC use by 16 yo

Answer 19

Friedreich’s ataxia

Question 20

Nerve biopsy of axonal sensory neuropathies

Answer 20

Abnormally large axons

Question 21

Which HMSN has retinitis pigmentosa

Answer 21

HMSN IV

Question 22

Which axonal sensorimotor neuropathy has birefringence with congo red staining

Answer 22

Amyloidosis

Question 23

HMSN I, III, IV are also known as

Answer 23

I = Charcot Marie Tooth
III = Dejerine Sottas
IV = Refsum's Disease

Question 24

UA findings seen in porphyria

Answer 24

Deep red

Question 25

Which axonal sensory neuropathy has pes cavus deformity

Answer 25

Friedreich's ataxia

Question 26

Amyloidosis neuropathy results from amyloid deposits in the ...

Answer 26

DRG

Question 27

3 Axonal motor > sensory neuropathies

Answer 27

1. Porphyria 2. Toxins 3. HMSN II

Question 28

First electrodiagnostic sign of CIDP

Answer 28

Abnormal F-wave

Question 29

Which toxin causes progressive onset upper limb weakness

Answer 29

Lead

Question 30

Which axonal sensory neuropathy is associated with RA

Answer 30

Sjogren's

Question 31

Most common cause of peripheral neuropathy worldwide

Answer 31

Leprosy

Question 32

Which axonal sensorimotor neuropathy causes bilateral hilar adenopathy

Answer 32

Sarcoidosis

Question 33

Which HMSN has floppy baby

Answer 33

HMSN III

Question 34

Which toxin causes ascending foot and hand neuropathy

Answer 34

Dapsone

Question 35

Which toxin causes blindness and epilepsy

Answer 35

Lead

Question 36

Which of HMSN has distal motor more than sensory of the LE > UE in stocking glove pattern

Answer 36

HMSN I

Question 37

Etiology of porphyria

Answer 37

Defect in heme synthesis

Question 38

Which toxin causes basophilic stippling in RBCs

Answer 38

Lead

Question 39

Which HMSN has bilateral foot drop

Answer 39

HMSN I

Question 40

EDx finding indicative of multifocal motor neuropathy

Answer 40

Multifocal motor conduction block

Question 41

Which toxin causes wrist drop

Answer 41

Lead

Question 42

Which of HMSN is autosomal dominant vs recessive

Answer 42

I, II = dominant | III, IV = recessive

Question 43

Which of HMSN I, III, IV has later onset?

Answer 43

HMSN IV - 3rd decade. The other 2 are within 1st 2 years

Question 44

What distinguishes demyelinating AIDP from axonal AIDP?

Answer 44

Axonal is areflexic

Question 45

Which toxin causes methemoglobinemia

Answer 45

Dapsone

Question 46

Which axonal sensorimotor neuropathy results in purpura

Answer 46

Amyloidosis

Question 47

Most common type of HIV related neuropathy

Answer 47

Distal symmetric polyneuropathy

Question 48

Csf findings of AIDP and CIDP

Answer 48

Increased protein

Question 49

What treatment do you use for CIDP that you do not use for AIDP

Answer 49

steroids

Question 50

Which axonal sensory neuropathy has lhermitte's sign

Answer 50

B6 toxicity

Question 51

Treatment of AIDP

Answer 51

Plasmapharesis, IVIG