Specific diseases Flashcards

1
Q

What pathogen causes feline infectious anaemia and how is it spread?

A
Mycoplasma haemofelis (intra-RBC)
Spread by fleas, blood transfusions or vertically
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2
Q

How is feline infectious anaemia treated?

A

Doxycycline or prednisolone

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3
Q

What 3 factors make up Virchows triad for risk of thromboembolism?

A

Endothelial injury
Hypercoaguability
Abnormal blood flow

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4
Q

How is polycythaemia treated?

A

Phlebotomy
Replace with colloids or electrolytes to relieve hyperviscosity
Hydroxycarbamide

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5
Q

How can you tell the difference between polycythaemia and dehydration based on clinical signs?

A

Dehydrated - tacky mucus membranes

Polycythaemia - hyperaemic mms +/- neuro signs, retinal detachment and blind

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6
Q

What is the treatment for multiple myeloma?

A

Chemotherapy - melphalan

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7
Q

What are the symptoms of Von Willebrand’s disease?

A

Mucosal bleeding
GI tract, epistaxis, haematuria
Increased bucosal bleedig time but normal PT/PTT

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8
Q

What breed is predisposed to Von Willebrand’s?

A

Dobermann

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9
Q

What is the treatment for Von Willebrand’s?

A

Cryoprecipiate (transfusion of vWF +/- whole blood if anaemic)
(Desmopression before procedure to cause release of vWF from endothelium)

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10
Q

Von Willebrand’s can be inherited or acquired. Give an example of a condition that may cause acquired vWF

A

Severe aortic stenosis

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11
Q

IMTP is primarily in what sex?

A

Females

Spaniels

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12
Q

Haemophila A and B are sex linked and are diagnosed by specific clotting assays. What is the difference between A and B?

A
A = deficiency of factor 8
B = deficiency of factor 9
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13
Q

What abnormal blood cells are often seen with DIC?

A

Shistocytes (fragmented RBC)

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14
Q

What is DIC?

A

Disseminated intravascular coagulopathies
Excessive coagulation causing microthrombi in organs
Leads to ischaemia, encrosis and organ failure
(Chronic better Px than acute)

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15
Q

What is the treatment for DIC?

A

Treat underlying cause
Heparin
Whole blood or plasma transfusion

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16
Q

What is neonatal isoerthrolysis?

A

Specific time of IMHA
Neonates’ RBCs destroyed by maternal antibodies
(Type A or AB kittens born to type B queen)

17
Q

What breed of cats is prone to neonatal isoerythrolysis?

A

British Shorthair

18
Q

How can neonatal isoerthrolysis be prevented/treated?

A

Avoid B queens mating with A/AB toms

Foster kittens for first 24 hours, give milk from cat with same blood type

19
Q

What type of anaemia does Mycoplasma haemofelis cause?

A

Regenerative anaemia
(Immune mediated haemolysis)
May be non regenerative if associated with FeLV or FIV

20
Q

How is Mycoplasma haemofelis diagnosed?

A

PCR (definitive)

21
Q

What anaemia does anaemia of chronic disease cause?

A

Normocytic, normochromic non-regenerative

e.g. kidney disease - decreased erythropoietin

22
Q

What is the treatment for anaemia of chronic disease?

A

No specific therapy - treat underlying cause

23
Q

What type of anaemias do FeLV and FIV cause?

A

Non-regenerative

24
Q

What may be an underlying cause of DIC?

A
Septicaemia
Immune mediated disease
Neoplasia
Cardiac disease
Trauma, heat stroke
25
Q

How does acute and chronic DIC affect clotting times and coagulation screening?

A

Acute - prolonged PT/PTT, thrombocytopenia

Chronic - normal coagulation screen, maybe thrombocytopenia

26
Q

What inherited coagulation defect causes prolonged PT without prolonged PTT?

A

Hereditary factor VII deficiency

27
Q

How is Anaplasma transmitted?

A

Flies

28
Q

How is Ehrlichiosis transmitted?

A

Ticks

29
Q

How is Babesiosis transmitted?

A

Ixodes ricinus ticks

30
Q

What is the treatment for Babesiosis?

A

Imidocarb

31
Q

What type of anaemia does a ruptured haemangiosarcoma cause?

A

Regenerative anaemia

32
Q

What type of anaemia does oestrogen toxicity cause?

A

Non-regenerative anaemia