Spasmolytics

Question 1

What is the target of Dantrolene?

Answer 1

decreases release from Ca2+ channels in the SR

Question 2

What drug is associated with liver toxicity

Answer 2

Dantrolene

Question 3

What drug targets the SNARE complex proteins?

Answer 3

Botulinum Toxins A and B

Question 4

What is the drug that targets GABA-B GPCR receptors?

Answer 4

Baclofen

Question 5

What is the MOA of Baclofen?

Answer 5

Serve as inhibitory NT or Activate channel by binding GPCR –> hyperpolarization –> no release of excitatory NT

Question 6

What drug is associated with minimal cognitive deficits?

Answer 6

Baclofen

Question 7

What is the older drug that causes sedation, confusion, hallucinations via the release of histamine?

Answer 7

Cyclobenzaprine

Question 8

What is the target of Riluzole?

Answer 8

Na+ channels

Question 9

What is the MOA of Riluzole?

Answer 9

Interferes with Na+ channels and inhibitrs release of glutamate

Question 10

Tizanidine is a…

Answer 10

centrally acting spasmolytic

Question 11

What drug has the following target: a2-adrenergic receptor agonist?

Answer 11

Tizanidine

Question 12

What is the MOA of tizanidine?

Answer 12

decreased release of excitatory NT via agonizing a2-adrenergic

Question 13

What drug is used for ALS and HD?

Answer 13

Riluzole

Question 14

What drug is associated with decreased lung function, vertigo, and pneumonia?

Answer 14

Riluzole

Question 15

What drug has both post and pre synaptic action on a2-adrenergic receptors?

Answer 15

Tizanidine

Question 16

What drug is used to treat malignant hyperthermia?

Answer 16

Dantrolene