Sore Throat Flashcards

1
Q

Best LRS for diagnosing strep

A

Tonsillar exudates
pharyngeal exudates
exposure to strep in last 2 weeks

other good ones : 
scarletiform rash
palatine petichiae
pharyngeal exudate
vomitting
and tender cervical adenopathy associated with GABHS pharyngitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Best negative LRS for diagnosing strep

A

absence of enlarged tonsils
absence of tender cervical adenopathy
absence of exudate

decrease the chance of strep

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is GABHS pharyngitis?

A

Group A Beta hemolytic strepococal pharyngitis

strep throat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

FeverPAIN scale

A

fever, purulence, attend rapidly, inflammed tonsils, no cough or coryza

used for streptococcus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

WHO strep approch

A

treat all children with pharyngeal exudate and enlarged tender cervical lymph nodes

not recommended
specific but not sensitive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

High moderate and low risk patients with potential strep throat Tx

A

Empiric - Abx for high risk
symptomatic therapy and follow up for low risk

delayed prescription and rapid antigen testing for moderate risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

T or False

the absence of exudate is enough to effectively rule out streptococcal pharyngitis as the bacteria congregate on the tonsils. Thus, the lack of exudate indicated no bacteral infection.

A

False :

no individual element of history taking or physical exams are accurate enough alone to rule in or out strep

However : Creamy exudate from tonsillar pillars b/c pf pustular nature of the infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Why do we care about knowing if it’s strep or not?

A

complications from strep may arise such as scarlet and rheumatic fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which lymph nodes drain the pharynx?

relevance

A

Anterior cervical nodes – which may become tender and enlarged during infection. (strep)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Is GABHS a commensal bacteria?

A

No, not apart of the normal throat flora

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

DDxs of strep

A
pharyngitis
tonsilitis
viral infections
absecesses
epiglotitis
Epstein Bar Virus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Strep presentation in adults vs children

A

Strep in adults is rapid onset

Symptoms less focal and more gradual in children

Both:

Severe throat pain and difficulty swallowing
Fever 39-40.5
Also typically present with malaise, mild stiff neck, GI symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

PE for strep?

what will we see? (5)

A

Examination of throat – erythema, edema of pharynx and uvula

Diffuse erythema and hypertrophy of the lymphoid tissue

Post pharynx pillars covered with grey white exudate, and it is beefy bright red, colour ending abrumptly at soft palate

Petichae on soft palate

Tonsils swollen with exudate

Breath is characteristically foul

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which condition is a complication of GABHS?

how does it present? 4

A

Scarlet Fever

erythematous papules trunk spreading sparing the palsm and soles
Blanches,
strawberry tongue
Pharyngeal ulcers also suggest group a b hemplytic strep

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

At what age does Step peak?

A

5-10 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Centor’s 4 item clinical prediction rule

explain

A

tonsillar exudate, swollen tender anterior cervical nodes, absence of cough, and history of fever. 1 point assigned for each of the patients signs and symptoms

Subtract ones if older than 45

used for the diagnosis of strep

Score 3-4 increases strep prob
0-1 very low risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Most common and freuqnet sore throat cause

other common (5)

A

viral infection of the pharynx (pharyngitis)

common cold 
influenza
mononucleiosis
environmental exposure
strep
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which structures are vital in emergency throat issues?

A

epliglottis : if inflammed can close off airway - emergent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Common Strep thoriat ‘no’ signs

A

No nasal symptoms
no cough

maybe some anterior cervical lymph node swelling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Localized vs. diffuse thorat pain

A

localized : more suggestive of a bacteria

diffuse - more viral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

How long do bengin sore throats take to heal?

A

within 5 days to resolve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Worse on waking sore thorat

A

post nasal drip, mouth breathing, sleep apnea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

worse after meals sore throat

A

GERD maybe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Red flags for sore throat (5)

due to? (3)

A

Airway distress (stridor, tachypnea, tripod posture, drooling, cyanosis)

due to obstruction (abscess, edema, neoplasm)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Pain on swallowing ST
pharynx (vs. larynx)
26
Fever and ST
Fever | infectious cause
27
Nasal symptoms and ST
allergies, viral
28
Cough and ST
viral, reflux, post nasal drip
29
Lymphadenopathy and ST
mono(systemic) | , bacterial infection, neoplasm?
30
Voice change and ST
abscess or enlarged tonsils; laryngeal involvement
31
Globus (what is it?) and ST
foreign body sensation; throat clearing) | neoplasm, GERD, post nasal drip
32
Pharyngitis/Tonsilitis info presentation ddx?
Most commonly associated with viral upper respiratory tract infection Commonly associated with low fever, cough, runny nose, lethargy Rule out : Group A β-hemolytic Strep (and other bacterial causes) 15-30% of pediatric cases More likely to have fever, more pain, anterior cervical adenopathy; lacking nasal symptoms or cough
33
White exudate on tonsils that are enlarged DDX
Tonsiltis Strep tonsils can be enlarged in kids because the immune system is working
34
Red petichiae on palate and uvula ddx
strep mono increases suspicison of bacterial infection
35
Why do we care about strep with a ST? (6) Other 2
Only cause of pharyngitis for which antibiotics may be indicated Risk of otitis media, peritonsillar abscess, rate of rheumatic fever, glomerulonephritis BUT substantial decline of the incidence of complications in high-resource settings Most cases of pharyngitis will self-resolve
36
Testing for Strep
Throat culture  gold standard, high sensitivity BUT higher cost and delayed treatment Rapid strep test : quick (10-20 min), and high specificity (can rule in) BUT low sensitivity (can’t rule it out, especially in children)
37
limitations of testing for strep
Neither Rapid strep test or throat culture can distinguish between carriage (5-20% of children) and actual infection (some kids just habour the bacteia without active infection - this is a problem - leads to chronic infections etc. )
38
What is the most appropriate thing to do if there is a suspected absess? why?
Peritonsilar - clinical assessment ultrasound or CT (might not be able to see on PE) Retro/parapharyngeal abscess - MRI CT(might not be able to see on PE) CBC (septicemia might be suspected)
39
predictors / increased likelihood of strep ( 5) score /implcations
``` Age 3-14 Tonsillar swelling or exudate No cough Temperature > 38°C anterior cervical adenopathy ``` 1 point for each : low score - no culture of Abx high score - 4 : RST - throat culture and Abx medium more : RST, if negative proceed to culture because it's not sensitive enough to rule out
40
Main concerns with pharyngitis Sx
peritonsillar/retropharyngeal abscess, epiglottitis Worsening or persistence of symptoms (should peak at day 3) Drooling, difficulty swallowing, respiratory distress, tripod positioning, stridor Trismus, muffled voice (“hot potato voice”) Stiff neck, external/unilateral neck swelling (neuro signs - meningitis) High fever, shaking chills, night sweats
41
Supraglottitis/Epiglottitis what? cause? presentation?
medical emergency infection of epiglottis and larynx with H. influenza B or β-hemolytic Strep Severe sore throat, odynophagia, high fevers Varying degrees of airway involvement Muffled voice, stridor, tachypnea, drooling, tripod position, use of accessory muscles sudden swelling --> obstruction
42
What to do if you suspect Epiglottitis
Don't do a PE Call 911 if a child is in respiratory distress, call 911 and try to keep the child calm and comforatble
43
What might be done for a child with suspected e\piglottitis in the ER?
Intubate X ray - see a thumb sign Laryngoscope is most sensitive CT if suspect an associated abscess (secure the airway)
44
what is the thumb sign?
“thumb sign” Epiglottitis. Widened epiglottis and aryepiglottic folds
45
Epstein-Barr Virus class causes? transmission
Herpes virus Cause of mononucleosis : Lymphoproliferative disorder Transmission via oral ingestion of viral particles (kissing, sharing drinks, etc.)
46
Populations that get mono the most
young adults 10-48 in NA
47
Pathogenesus of EBV
ingested inhaled etc. infects B cells Rupture of B-cells and transmission of virus to new cells T ceel proliferates (CD8Ts, NKs) to destroy infect B cells B cell produce Abs IgM (acute), IgG (previous), Heterophil Abs
48
Why is there widespread lymphadonopathy in mono?
because T cells proliferate, infection of B cells therefore , the infection happens systemmically
49
Splenomegaly and relevance?
enlarged spleen relevant in acute EBV
50
Enlarged liver and releavnce
hepitis which may develop in EBV
51
What happens once EBV has been cleared by the body?
there are a small population of infectedB cells that may activate or proliferate rare IgG serology
52
Possible Mononucleosis presentation (12
Fever pharyngitis extreme fatigue swollen tonsils exudate petichiae body rash ( non specific) generalized lymphadenopathy Splenomegaly Hepatitis, pneumonitis, meningoencephalitis
53
Body rash with ST after amoxicicillin/penicillian use
treated on suspicion of GABHS treated for the wrong organism they have mono therefore non-specific body rash
54
How long does it take for mono to clear?
Can last 3 weeks fatigue can last for months
55
What to do if you suspect mono?
rapid strep test to rule out strep | culture
56
Clinical features of Mono
sore throat, lymph node enlargement, fever and tonsillar enlargement - 98% (very typical lof mono) pharyngeal inflammation - 85% petichiae (50%)
57
Posterior cervical lymphadenopathy
higher LR in Mono (3,1)
58
Confirmatiory labs for EBV/Mono (4) and why?
1. CBC and peripheral blood smear Lymphocytosis (increases WBC) Distinctive atypical lymphocytes (CD8) 2. Monospot (heterophil antibody) (doesn’t rule it out) 3. Rapid strep test … why? 4. Serology IgM and IgG for EBV (viral capsid antigen, nuclear antigen) Also titers (Abs) for Cytomegalovirus (looks like EBV)
59
What is a monospot test? | what does it test for?
Heterophil Antibodies blood mixed with sheep, and reacts and clumps if positive (doesn’t rule it out)
60
What do IgM Abs suggest? relevant condition?
Acute infection discussed in mono ( EBV)
61
Possible complications with EBV
Hepatic involement ( hepatistis) splenic rupture ( more sensitive)
62
Possible long term sequele of EBV (4)
Nasopharyngeal carcinoma Burkitt lymphoma Chronic Fatigue Syndrome? Fibromyalgia? more likely to be malignant if incapable of controlling B cell activity
63
Rhinosinusitis/post-nasal drip: | and ST presentation
Irritated throat, globus, excessive phlegm, cough Other manifestations of rhinorrhea, congestion, facial pressure, etc.
64
what is globus?
foriegn body sensation in the throat
65
Neoplasm and ST
Globus, irritation well localized pain voice change weight loss lymphadenopathy
66
Thyroiditis and ST
Hyperthyroid symptoms (heat intolerance, restlessness, agitation, diarrhea, tremor, etc.) Visibly enlarged thyroid gland
67
Hoarseness involves what? how long? red flags?
Involving the larynx (not typically painful) More concerning when persistent (ie. >3 weeks) voice overuse, steroid use, recurrent URTI etc. Red flags: smoking, dysphagia, odynophagia or otalgia, stridor, haemoptysis and recent fevers, night sweats and unexplained weight loss more concerned about persistant : want to rule out malignancy
68
Laryngitis what? why? predisposition? infancy?
typically d/t URTI, or smoking tobacco related presiposition for cancer serious in infancy due to croup , exudate, edema etc
69
Vocal cord polyps/nodes what? who? other 2
common begnin tumor nodes : bilat , polyps : unilat rarely develops into cancer due to irritation : heavy smokers and singers constant trauma : attempt to repair : other side might ulcerate with contact
70
Papilloma ST what? what might happen?
HPV 6 and 11 associated Soft neoplasms; fibrovascular core covered with stratified squamous epithelium Contact with opposing vocal cord may cause trauma or hemoptysis (coughing up blood)
71
Gonococcal Pharyngitis ST history PE/presentation next steps
His : orogenital sexual activity Pharyngeal exudate bilateral cervical lymphadenopathy gram stain and gonorrhea culture
72
Herpangia ST aka history PE/presentation next steps
coxsackievirus more common in children, immunosuppressed painful throat, fever, malaise Lymphadenopathy soft grey papulovesicular lesions on the soft palate and pharynx serology
73
Aphthois stomatis ST aka history PE/presentation next steps
canker sores oral trauma painful ulcers varying in size abscence of other symptoms shallow ulcers yellow membrane and red halo no fever or nodes no next steps
74
Fusospirochetal infection ST aka history PE/presentation next steps
Vincent angina Poor oral health painful ulcers foul breath bleeding gums grey necrotic ulcers on gingival margins gram stain reveals spirochetes
75
Herpes Simplex ddx ST history PE/presentation next steps
trauma to mucosa, pain, perioral lesions lymphadentitis (enlargment of 1 or more nodes) viral culture
76
Candidiasis ST history PE/presentation next steps
yeast infection immunosupressed , Abx use, diabetes curdlike white plaques that bleed when scraped off KOH prep