Solubility and Dissolution

Question 1

Solubility decreases as

Answer 1

a molecule gets bigger (higher MW)

Question 2

Solubility increases as

Answer 2

a molecule gets smaller (lower MW)

Question 3

Aqueous solubility decreases with

Answer 3

increasing boiling and melting point

Question 4

Aqueous solubility increases with

Answer 4

decreasing boiling and melting point

Question 5

Ionization of substituents (incr. or decr. solubility)

Answer 5

increase solubility

Question 6

Polar functional groups (incr. or decr. solubility)

Answer 6

increase solubility

Question 7

Non-polar functional groups (incr. or decr. solubility)

Answer 7

decrease solubility

Question 8

What is the most common cosolvent?

Answer 8

alcohols

Question 9

Henderson Hasselbach equation

Answer 9

pH=pKa + log(concentration of conjugate base (A)/concentration of weak acid (HA))

Question 10

ADME

Answer 10

absorption–> distribution–> metabolism–> elimination

Question 11

Cmax

Answer 11

maximum concentration

Question 12

Tmax

Answer 12

the time Cmax happens

Question 13

AUC

Answer 13

area under the curve

Question 14

t 1/2

Answer 14

half-life (time for drug concentration to fall by half)

Question 15

Cmin

Answer 15

minimum concentration

Question 16

MTC

Answer 16

maximum therapeutic concentration

Question 17

MEC

Answer 17

minimum effective concentration