Solubility Flashcards

1
Q

Poor solubility/dissolution can affect

A

High-throughput screening (HTS ) assays
* The ability to achieve efficacious and toxicologically
relevant exposures in animals.
* The bioavailability of the drug from the formulation.
* Possibility of increased “food effect”
* Inability to provide liquid formulations e.g injections ,
paediatric / geriatric dosage forms

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