Solid Dosage Forms I Flashcards
What is a dosage form?
It is the physical form by which drug molecules are delivered to their site of action.
What are solid dosage forms?
Solid dosage forms are dosage forms which are solid in physical
form.
They are made up of an active pharmaceutical ingredient
or a combination of active pharmaceutical ingredients and
excipients, most of which occur in solid state.
What is a powder?
A pharmaceutical powder is defined as a dry, solid dosage form, composed of finely divided drugs with or without excipients and intended for internal or external use
What are the 2 forms in which powders may exist?
- Crystalline
- Amorphous
Mention 5 chemical and physical features used to characterise powders.
- Morphology
- Purity
- Solubility
- Flow properties
- Bulk and tapped densities
- Particle size
- Compatibility with other formulation components.
Mention 4 advantages of powders.
- Better physicochemical stability than liquid dosage forms.
- Suitable for children or adults who have difficulty swallowing capsules and tablets.
- Effective for providing larger dose than other dosage forms
- Mixing of multiple medical agents provides great versatility to the medicine through therapeutic synergy
Mention 4 disadvantages of powders.
- Drugs with unpleasant taste are difficult to consume in powder form.
- Powdered medicine is heavy and bulky
- Hygroscopic drugs cannot be dispensed in powdered form
- May not be suitable for oral administration where the medicine my harm the stomach or be inactivated in the stomach.
What are the processes involved in the preparation of powders?
i. Particle size reduction
ii. Sieving
iii. Weighing each ingredient
iv. Mixing
v. Packaging
Size reduction is also called:
- Comminution
- Pulverization
- Grinding
Mention 4 methods of large-scale size reduction with examples.
- Compression: Application of positive pressure e.g. ball mill.
- Impact: Hitting stationary material e.g. hammer mill
- Shear: cutting force e.g. colloid mill
- Attrition: breaking the edges of the solid by impact or particle collision e.g roller mill, fluid energy mill
Mention 4 methods of mixing powders.
- Spatulation
- Trituration
- Geometric dilution
- Tumbling
Spatulation is suitable for large quantities of powders or for powders containing one or more potent substances.
True or False
False.
It is not suitable because homogenous blending may not occur.
Which mixing method is most suitable when potent substances are to be mixed with large amounts of diluent?
Geometric dilution.
How are powders to be packaged?
Powders may be wrapped in paper or dispensed in bulk powder in a wide
mouth container.
Mention 6 types of powders.
- Bulk powder
- Insufflations
- Powder sprays
- Effervescent powder
- Divided powders
- Dusting powder
- Douche powder
- Dentifrices
BIPED4
How are bulk powders packaged?
They are supplied in wide-mouthed containers that permit easy removal of a spoonful powder.
The major problem with bulk powders is inaccuracy of dose. Mention 2 factors that may affect dosage.
- Measuring spoon
- Humidity
How are dusting powders packaged?
In a glass/metal container with a perforated lid (sifter top containers)
to allow powders be dusted to the affected area.