SOLID DOSAGE FORMS Flashcards
These are tablets designed to pass unchanged through the stomach to the intestines, where the tablet disintegrates
a. Layered tablets
b. RDTs
c. Sugar-coated tablets
d. Enteric-coated tablets
D.
These are compressed tablets coated with substances that resist dissolution in gastric fluid but integrate in the intestine.
I. Film-coated tablets
II. Sugar-coated tablets
III. Enteric-coated tablets
A. I only C. I and II E. I, II and III
B. III only D. II and III
B. III only
These tablets were originally used by physicians in the extemporaneous preparation of parenteral solutions.
I. Chewable tablets
II. Dispensing tablets
III. Hypodermic tablets
A. I only C. I and II E. I, II and III
B. III only D. II and III
B.
The following statement/s is/are true for compressed tablets:
I. These are tablets formed by compression and may contain another special coating if desired.
II. Tablet diameters and shapes are determined by the die and punches used in the compression of the tablet.
III. They are made from powdered, crystalline, or granular materials, alone or in combination with binders, disintegrants, controlled-release polymers, lubricants, diluents and colorants.
A. I only B. I and II C. II only D. II and III E. I, II and III
D.
This is a method of preparing tablets in which the powder mixture is compacted in large pieces and subsequently broken down or sized into granules.
A. Wet granulation
B. Dry granulation
C. Direct compression
D. Two of the choices
B.
The following statement/s is/are true for wet granulation method:
I. Liquid binder is added to the powder mixture to facilitate the adhesion of the powder particles
II. Over-wetting of the powder can result in granules that are too soft for proper tableting and under-wetting can result in tablets that are too hard
III. Granules may be dried in thermostatically controlled ovens which constantly record the time, temperature and humidity.
A. I only B. I & II C. I & III D. II & III E. I, II, III
C.
Dry granulation:
Used for tablet
I. Ingredients that is sensitive to moisture or unable to withstand elevated temperature during drying
II. One of the constituents, either the active ingredient or the diluents, must have cohesive properties
III. Includes more number of steps than wet granulation
A. I only
B. I & II
C. I & III
D. II & III
B.
This the only carbohydrate used in the preparation of compressed tablet which possesses high heat stability.
A. lactose B. mannitol C. sucrose D. starch E. fructose
B.
The following statement/s is/are true used in the preparation of sugar-free chewable tablets?
I. Mannitol is used as the excipient in most chewable tablets.
II. These tablets are formulated to disintegrate smoothly in the mouth with or without active chewing.
III. These tablets are particularly useful for children and adults who have difficulty swallowing other solid dosage forms
A. I only
B. I & II
C. I & III
D. II & III
E. I, II, III
E.
Which excipient/s is/are used in the preparation of sugar-free chewable tablets?
I. Lactose
II. Dextrose
III. Xylitol
A. I only B. III only C. I & II D. II & III E. I, II, III
C.
Tablet coating has the following advantage/s:
I. Protect the medicinal agent destructive exposure to air and/or humidity
II. Mask the unpleasant taste of the drug
III. Provide special characteristics of drug release
A. I only B. I & II C. II & III D. I & III E. I, II, III
E.
Tablet coating has the following advantage/s:
I. Protect the medicinal agent destructive exposure to air and/or humidity
II. Mask the unpleasant taste of the drug
III. Provide special characteristics of drug release
A. I only B. I & II C. II & III D. I & III E. I, II, III
E.
Film coated tablets possess the following characteristic/s:
I. Less resistant to destruction by abrasion than are sugar coated tablets
II. Coating may be colored to make tablets attractive and distinctive
III. Film-coating solutions may be non-aqueous or aqueous
A. I only B. I & II C. II only D. II & III E. III only
D.
This substance provides water solubility or permeability to the film to ensure penetration by body fluids and therapeutic availability of the drug.
A. alloying substance
B. Plasticizer
C. film former
D. surfactant
E. glossant
39. Problems encountered on the use of aqueous based film coating solution include:
I. Slow evaporation of the solvent-based solutions
II. Expensive as compared to volatile solvents
III. Increased likelihood of water interference with the tablet formulation
A.I only B. III only C. I & III D. II & III E. I, II, III
D.
This is a problem often encountered in film coating process characterized by roughness of the tablet surface due to failure of spray droplets to coalesce.
A. peeling B. picking C. orange-peel effect D. mottling E. bridging
C
