Soft Tissue Tumors Flashcards
What is a lipoma/liposarcoma?
A lesion with very atypical cells and lipoblasts (atypical cell with bizarre nucleus and vesicles of lipid in the cytoplasm) - this is the strangest definition ever
What is nodular fasciitis?
Rapidly growing, small, benign, fibrous proliferation on the subcutis; prevalent in young adults and presents with a history of rapid growth
What is Myositis Ossificans?
Reactive bone formation in muscle as a result of injury; woven bone in granulation tissue
Is myositis ossificans benign?
Yes but it can mimic neoplasm
How does myositis ossificans occur?
Usually from blunt trauma, often in lower limb
Where is the woven bone of myositis ossificans prevalent?
In the periphery; immature at center, and late stages can contain cartilage/lamellar bone
What is superficial fibromatosis?
Small lesions of the hand, feet, and penis; occur in young males; arise in digits of infants and children and are characterized by peculiar inclusion like condensations of cytoplasmic action
What is characteristic of superficial fibromatosis?
Dupuytren contraction
What is deep fibromatosis?
Rare condition in which tumors are large, and local control is hard to achieve; they dont metastasize. In females in late 20’s it ail be in the abdominal wall; later on it will be fewer abdominal tumors and no sex predominance
What is a fibrosarcoma?
A tumor of mesenchymal cell origin that is composed of malignant fibroblasts in a collagen background; can occur as a soft tissue mass or bone tumor
Are fibrosarcomas painful? where in the bone do they occur?
Yes, and in the metaphysis of long bones and pelvis
At low power, what do fibrosarcomas demonstrate?
A herringbone pattern
What is a dermatofibroma?
A.k.a. fibrous histiocytoma and due to non-cancerous growth of dermal dendritic histiocyte cells; in some cases due to minor injury; cause is unknown
Where do dermatofibromas occur and how do they look?
Legs and arms and once they develop they persist for years; appear as firm nodules, often yellow-brown, sometimes pink and sometimes dark
What is dermatofibrosarcoma protuberans?
DFSP is relatively uncommon soft tissue neoplasm with intermediate to low grade malignancy; it is a locally aggressive tumor with high recurrence rate
What is malignany fibrous histiocytoma?
MFG is controversial; accounts for about a quarter of soft tissue sarcomas; it contains both fibroblast and histiocyte like cells in varying proportions with spindled and rounded cells exhibiting storiform arrangement
What is a rhabdomyosarcoma?
A fish flesh like white tumor made up of cancerous muscle cells called rhambdomyoblasts; they can arise in any muscle
What are most common sites for rhabdos?
Adjacent to the base of skull, around the eye, head and neck (nasopharyngeal), arms and legs, urinary system and repro tract
What cells are rhabdos usually made up of?
Bizarre elongated strap cells
What is a leiomyoma?
Neoplasm of smooth muscle, most common site is uterus; their etiology is unknown, they affect 25-40% of women in child bearing age, and are usually asymptomatic, only removed if painful, can be anywhere b/c smooth muscle is everywhere
What cell is typical of leiomyomas?
“cigar” shaped cells
What is a leiomyosarcoma?
Can arise anywhere in the body, more common in uterus abdomen, or pelvis; not much other info given except survival based on histological grade; size and invasiveness
Why do sarcomas met to the lung so easily?
They travel through the blood stream, not lymph; pulm mets major cause of mortality for all sarcoma patients (not just leiomyosarcoma)
