Soft Tissue Sarcomas Flashcards
What is the origin of soft tissue sarcomas?
mesenchymal cells
- peripheral nerve sheath tumors
- hemangiopericytomas
- fibrosarcomas
- liposarcomas
- malignant fibrous histiocytomas
- myxosarcomas
- rhabdomyosarcomas
- leiomyosarcomas
How do soft tissue sarcomas act?
very locally invasive –> metastatic potential by histologic grade
- local recurrence common following conservative excision
How does diagnosing soft tissue sarcomas compare to MCTs?
OFTEN NOT DEFINITIVELY DIAGNOSTIC
- may read as spindle cell proliferation with well-differentiated tumors
- poorly exfoliates
What sample is required for grading soft tissue sarcomas?
biopsy
What is the site of preference for soft tissue sarcoma metastasis?
lungs –> appear as pulmonary nodules
When are CTs/MRIs recommended in cases of soft tissue sarcomas?
surgical planning for tumors on the trunk
- external palpable tumor is often the tip of the iceberg!
What type of surgery is recommended for treating soft tissue sarcomas?
wide excision with a minimum 3 cm margins
- amputation not needed unless painful or an open wound is present and a more conservative surgery would not be feasible or effective
When is radiation and chemotherapy recommended for cases of soft tissue sarcomas?
RADIATION - adjuvant to surgery if margins are incomplete or narrow
CHEMO - metastasis present, high grade tumors, visceral sites affected (splenic)
What chemotherapy protocols are most common for soft tissue sarcomas?
Doxorubicin (Adriamycin)
What 3 factors are assessed when grading soft tissue sarcomas?
- differentiation
- percent necrosis in tumor
- mitotic index
