Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Epilepsy > Sodium Valproate > Flashcards

Sodium Valproate Flashcards

1
Q

HIGH RISK

A

Highly TERATOGENIC!!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Action

A

Weak inhibitor of neuronal sodium channels, stabilizes resting membrane potential and reduces neuronal excitability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Use

A

1st line in all generalised seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Pregnancy

A

MHRA: Valproate medicines (Epilim, Depakote) contraindicated in women of child-bearing ages unless in Pregnancy Prevention Programme and NO other alternative. Contraindicated in pregnant women with bipolar disorder and only used if NO alternative

Consult GP immediately if pregnant / planning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Valproate Pregnancy Prevention Programme

A

Specialist supervision
7 day prescription validity, 30 day supply
Use highly effective contraception
1. IUD, POP implant, sterilization
2. x2 methods COC + barrier + reg pregnancy testing
Exclude pregnancy before treatment
Fully informed patient info -signed risk acknowledgement form and annual review

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Risk minimisation material to support PPP

A

For patients - patient guide, patient card, risk acknowledgement form
For HCPs - Healthcare professional guide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Actions for pharmacist every time dispense

A
  1. provide patient card
  2. remind pt of risks
  3. remind pt of effective contraception
  4. annual review?
  5. dispense whole pack and PIL
  6. patient guide
  7. if of child-bearing age and not using effective contraception refer/contact GP
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Actions of GP

A
  1. Provide patient guide
  2. Check review date
  3. Check effective contraception
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Actions of specialist

A
  1. Book annual review

2. Risk Acknowledgement Form signed and keep copy for pt, specialist and GP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Side effects

A
  1. Hepatotoxicity (FATAL)- report persistent vomiting, abdo pain, jaundice, malaise, drowsiness. Discontinue if abnormally prolonged PROTHROMBIN TIME
    * Monitor LFTs
  2. Blood dyscrasias e.g. leucopenia, thrombocytopenia. Report infections signs
    * MONITOR FBC
  3. Pancreatitis - report abdo pain, nausea, vomiting
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Interactions - anticonvulsant effect antagonised

A

LOWER SEIZURE THRESHOLD 1. Quinolones

  1. Mefloquine
  2. SSRIs
  3. Antipsychotics
  4. TCAs / anti-depressants
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Interactions - increase risk of hepatotoxicity

A

HEPATOTOXIC DRUGS

  1. Statins
  2. Carbamazepine
  3. Tetracycline
  4. Fluconazole
  5. Isoniazid
  6. Itraconazole
  7. Methotrexate
  8. Sulfasalazine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Epilepsy (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions