SNRIs

Question 1

MOA: inhibitor of SERT and weak inhibitor of NET without much affinity for histamine, alpha-adrenergic and cholinergic receptors (unlike TCAs); better tolerated as a result of this selectivity
Use: treatment of MAJOR DEPRESSION, neuropathies, fibromyalgia, generalized anxiety, stress urinary incontinence, vasomotor symptoms of menopause

Answer 1

venlafaxine

Effexor

Question 2

MOA:balanced inhibitor of NET and SERT without affinity for histamine, alpha-adrenergic or cholinergic receptors, making them better tolerated than TCAs
Use: MAJOR DEPRESSION, CHRONIC PAIN, PTSD, OCD, social anxiety disorder, GAD & panic disorder
-chronic pain is associated with depression, and inhibition of NE and 5-HT reuptake is useful for treating pain

Answer 2

duloxetine

Cymbalta

Question 3

MOA: balanced inhibitor of NET and SERT without affinity for histamine, alpha-adrenergic or cholinergic receptors, making them better tolerated than TCAs
Use: MAJOR DEPRESSION, PTSD, OCD, social anxiety disorder, GAD & panic disorder

Answer 3

desvenlafaxine

Pristique