Smooth Muscle Pharmacology

Question 1

Describe angina and the pharmacological manipulation of smooth muscle contraction.

Answer 1

• Angina is an inadequate myocardial oxygen supply that involves fixed vessel narrowing and endothelial dysfunction.
• Stable angina: borought on by exertion, relieved at rest
• unstable angina: symptomatic even at rest

Question 2

Describe effects of organic nitrates on venodilation.

Answer 2

• induces venodilation
• venodilation reduces venous pressure and venous return to the heart.
• reduces oxygen demand

Question 3

What is hypertension?

Answer 3

• Dialostic blood pressure 90 mmHg

- Systolic blood pressure 140 mmHg