Smoking and Psychosis Flashcards
1
Q
What is the prevalence of smoking among people with Schizophrenia vs general population?
A
65% vs 20%
2
Q
What are the 3 main hypothesis for high smoking in Schizo?
A
1) Causal (smoking —> psychosis)
2) Self-medicating (Psychosis —> smoking)
3) Shared diathesis (stress/genetics -> smoking & psychosis)
3
Q
What part of smoking induced the metabolism of other substances?
A
Tabacco, not nicotine!
It induces the liver enzyme CYP1A2 – increasing the rate of metabolism of other 1A2 substrates = more dose of Clozapine/Olanzapine are needed
4
Q
How does nicotine affect metabolism?
A
Reduces insulin level, increasing blood glucose and insulin resistance
reduces cravings for sugary foods
risk of diabetes
Stimulates stomach/Gastric motility
Nausea
Reduced appetite
