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H&D T3Q7 > Smith NSAIDs, Glucocorticoids, DMARDs > Flashcards

Smith NSAIDs, Glucocorticoids, DMARDs Flashcards

1
Q

Mechanism of NSAIDs

A

Inhibit Cyclooxygenase enzymes

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2
Q

Mech of Glucocorticoids

A

Inhibit phospholipase A2 (PLA2)

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3
Q

WHat does DMARD stand for

A

Disease modifying anti-rheumatic drugs

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4
Q

Types of DMARDs

A

1) Non - biologic

Biologic

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5
Q

What are eicosanoids

A

Oxygenation products of poly-unsaturated long-chain FA

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6
Q

In what fashion do eicosanoids act?

A

Autocrine

Paracrine

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7
Q

What type of proteins are eicosanoids

A

G coupled protein

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8
Q

Prostanoid is a sub classification of

A

Eicosanoids

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9
Q

Types of prostanoids

3

A

Prostaglandins
Thromboxanes
Prostacyclins

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10
Q

Prostanoids have major effects on?

5

A

1) Platelets and blood cells
2) Adipose Tissue
3) nerve terminals
4) endocrine organs
5) smooth muscle
BANES

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11
Q

Difference in function b/w COX1 or COX 2 inhibitors

A

COX 2 selective inhibitors do NOT inhibit platelet aggregation or cause GI upset/ulceration

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12
Q

3 NSADIS are

A

aspirin
ibuprofen
naproxen

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13
Q

contraindication of aspirin

A

Bleeding disorders
ace nhibitor
methotrexate
children with viral induced illness (reyes syndrome)

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14
Q

mechanism of nsaids

A

non - selective cox1 and 2 inhibition

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15
Q

what is the only nsaid to inhibit both COXs in an irreversible manner?

A

aspirin

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16
Q

what is aspirin primarily valued for?

A

anti-platalet aggregation effects

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17
Q

when is aspirin used for anti-inflammatory purposes?

A

RARE bc needs too high of a dose

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18
Q

ibuprofen function

A

analgesic
antipyretic
anti-inflammatory

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19
Q

what does ibuprofen interfere with

A

antiplatalet effect of aspirin

20
Q

what makes naproxen unique?

A

slow-release

21
Q

adverse effects of all nsaids

A

GI problems

Reyes syndrome

22
Q

what is the name of a cox 2 selective inhibitor

A

celecoxib

23
Q

celecoxib functions

A

analgesic
antipyretic
anti-inflammatory

24
Q

what effect does celecoxib have on platalet aggregation

A

none

25
Q

how much more selective for cox 2 is celecoxib

A

10-20x

26
Q

acetaminophen mechanism

A

effect on hypothalamus to reduce fever

analgesic mech through elevation of pain threshold

27
Q

what is adverse effect of acetaminophen

A

liver failure

28
Q

is acetaminophen anti-inflammatory

A

NOOO!O

29
Q

Glucocorticoids mech in depth

A

prevents conversion of membrane phospholipids to arachidonic acid by inhibiting the phospholipase A2 enzyme

30
Q

short to medium actic glucocorticoids are

A

hydrocortisone
cortisone
prednisone

31
Q

ling acting glucocorticoid is

A

dexamethasone

32
Q

prednisone mech

A

blocks phospholipase A2, thus shutting down immune response

33
Q

non-biologic dmard mech

A

supress progression of disease by actions against underlying immunological abnormalities

34
Q

two non biologic dmards are

A

methotrexate

azathioprine

35
Q

what is the 1st line dmard for rheumatoid arthritis

A

methotrexate

36
Q

methotrexate mech

A

inhibits transformylase and thymidylate synthetase

37
Q

methotrexate adverse efects

A

contraindicated in pregnancy

contraindicated with nsaids

38
Q

azathioprine mech

A

supresses dna synthesis and production of b-cells and t cells

39
Q

azathioprine adverse effects

A

bone marrow supression

40
Q

what size of molecules are biologic dmards

A

large molecules

41
Q

two biologic dmards are

A

(abatacept) t-cell modulators

(adalimumab) tnf alpha blocking agents

42
Q

abatacept mech

A

fusion protein that prevents activation of t-cells

43
Q

abatacept monthly cost?

A

3700

44
Q

adalimumab mech

A

prevents ligand from binding to tnf alpha receptor

45
Q

4 human monoclonal antibody options are

A

1) infliximab
2) adalimumab
3) certolizumab pegol
4) golimumab

H&D T3Q7 (1 decks)

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