Small molecule and Targeted therapy

Question 1

Name 3 Cancer Hallmarks

Answer 1

Induce angiogenesis
Resisting cell death
Activation invasion and metastasis
Enabling replicative immortality
Sustaining proliferative signaling
Evading growth suppressors

Question 2

mAb, what is the component?

Answer 2

Fab region: binds to the target antigen
Fc region: effector effect

Question 3

Direct mechansim of Immunotherapy

Answer 3

Bind to the target receptor of cancer cell, internalization and inhibit oncogenic cellular signaling

Question 4

What is the indirect mechanism of immunotherapy?

Answer 4

ADCP engulf and digest cells or particles that are coated with antibodies -> recognize and ingest these target cancer cell

ADCC NK cell (cytotoxic immune cell) kill the antibody-coated target cells

CDC means the complement cascade is a result of antibodies bind to the antigen, lead to a membrane attack that cause cell lysis