Small Bowel Flashcards
Most common cause of pediatric diarrhea
Rotavirus
Types of diarrhea
Infectious, malabsorption, osmotic, increased motility, secretory
Ddx of chronic diarrhea
Secretory: carcinoid tumor or VIPoma
Malabsorption/maldigestive/osmotic: bacterial overgrowth, pancreatic insufficiency, mucosal damage, lactose intolerance, celiac dz, laxative abuse, short bowel syndrome
Inflammatory: IBD
Increased motility: IBS
When to workup acute diarrhea
Further workup if patient has a high fever, bloody diarrhea, or diarrhea > 4-5 days
Watery vs. bloody diarrhea organisms
Watery: Vibrio cholera, ETEC, Giardia, C diff, rotavirus, Cryptosporidium
Bloody: EHEC, Salmonella, Shigella, Campylobacter
Campylobacter:
-Hx, Exam, Tx
Hx: most common etiology of bacterial diarrhea; ingestion of contaminated food/water; affects young children and young adults
Exam: Fecal RBCs and WBCs; p/w bloody diarrhea, fever, and no abdominal pain
Tx: erythromycin
C diff
-hx, exam, tx
Hx: a/w recent antibiotic use (especially clinda) and recent hospitalization
-be careful about toxic megacolon
Exam: p/w fever, abdominal pain, systemic toxicity; fecal RBCs and WBCs
-causes colitis; dx w/ toxin in stool; sigmoidoscopy shows pseudomembranes
Tx: PO metronidazole or PO vanc; IV metronidazole if pt can’t tolerate PO
Entamoeba histolytica
-hx, exam, tx
Hx: 2/2 ingestion of contaminated food or water (Trave)
Exam: severe abdominal pain and fever; fecal RBCs and WBCs; endoscopy shows flask-shaped ulcers”
-mimics IBD if chronic
Tx: steroids can cause fatal perforation. DON’T USE STEROIDS; tx w/ metronidazole
E. coli 0157:H7
-Hx, exam, tx
Hx: bloody diarrhea, ingestion of raw meat; lasts 5-10 days
Exam: p/w severe abdominal pain, low-grade fever, vomiting, and bloody diarrhea; fecal RBCs and WBCs
-rule out GI bleed and ischemic colitis; HUR is a potential complication (thrombocytopenia and renal failure)
Tx: avoid antibiotics or antidiarrhea therapy because they increase HUS risk
Salmonella
-hx, exam, tx
Hx: 2/2 ingestion of contaminated poultry or eggs
Exam: p/w prodromal HA, fever, myalgia, and abdominal pain
- Fecal WBCs
- sepsis is a concern as 5-10% of pts become bacteremic; sickle cell pts are prone to osteomyelitis
Tx: oral quinolone or TMP-SM if pts are bacteremic or have sickle cell
Shigella
-Hx, exam, tx
Hx: very contagious, transmitted fecal-oral
Exam: fecal RBCs and WBCs; bloody diarrhea
-can cause severe dehydration and febrile seizures
Tx: TMP-SMX to prevent spread
Intestinal villous atrophy
a/w Celiac disease
Dermatitis herpetiformis
a/w celiac dz
grouped, papulovesicular pruritic skin lesions
symmetrically located on extensor surfaces of elbows, knees, buttocks, and posterior scalp
Frequent, loose, watery stools which are pale, foul-smelling, bukly
a/w abdominal pain, flatus, bloating, weight loss, nutritional deficiencies, and fatigue
Malabsorptive diarrhea
ddx: mucosal (Celiac, Whipples dz, tropical sprue), bile salt deficiency (bacterial overgrowth), pancreatic insufficiency, or short bowel syndrome
Pellagra
Sx: Diarrhea, dementia, dermatitis, death
-high sensitivity to sunlight; ataxia, confusion, insomnia; beefy, red glossitis; dilated cardiomyopathy;
Vitamin B3 (niacin) deficiency 2/2 decreased niacin or tryptophan intake