Small Animal GI & Dentistry Flashcards
Hematemesis
the vomiting of blood
Which of the following is considered a Primary GI cause of vomiting
Dysautonomia
Vestibular disease
Addison’s disease
Non-steroidal anti-inflammatory drugs
Non-steroidal anti-inflammatory drugs
Along with fresh blood in the stool, which of the following is most consistent with Large Bowel Diarrhea
A) large volume of feces
B) weight loss
C) tenesmus
D) melena
tenesmus
Along with blood in the feces, which of the following would most motivate you to submit a fecal culture for Salmonella
raw food diet
Both Whipworms & Hookworms cause anemia, which one of these is most likely to cause melena
Hookworks
(Small Bowel Diarrhea)
An elevation in which cell type on the CBC is most consistent with intestinal parasitism
eosinophils
The pancreas is critical for the absorption of which of the following in the distal small intestine
cobalamin
Young German Shepherds appear to be susceptible to a number of GI problems, including Exocrine Pancreatic Insufficiency (EPI). The best test for EPI is to measure
trypsin-like immunoreactivity
Are hookworms zoonotic
Yes
Which MDB abnormalities are most consistent with a protein-losing enteropathy
hypoalbuminemia & hypoglobulinemia
Physical examination confirms that Dixie’s belly is distended, and fluid analysis identifies a TRANSUDATE. Which of the following causes a transudate
hypoalbuminemia
Which Breed appears to be predisposed to developing Lymphangiectasia
Yorkshire terriers
What is the drug of choice for treating constipation in cats?
cisapride
Physical examination and minimum database suggest Rex has chronic kidney disease. Is this a Primary or Secondary GI rule-out for the clinical sign of vomiting
Secondary GI
Radiographs reveal that Rex is constipated. Could constipation cause Rex’s clinical signs of vomiting and decreased appetite ?
Yes due to the colonic input to the emetic center
Chronic diarrhea & weight-loss are most consistent with disease of the
A) Esophagus
B) stomach
C) Small Intestine
D) Large Intestine
Small Intestine
In a 14 yr old cat (geriatric) presenting for chronic diarrhea & weight-loss, the top 2 Primary GI rule-outs would be
1) IBD
2) Lymphoma
Because of the acute vomiting you suspect a GI foreign body and order abdominal radiographs. The radiographs reveal gas in the duodenum and loss of corrugated intestines; both of which might be seen with a GI FB. What 4 radiographic signs put Pancreatitis on your rule-out list
1) Gas-filled Duodenum
2) Soft Tissue Opacity
3) Decreased serosal detail
4) Wide Pyloric Duodenum Angle
Is the Pre- and Post Prandial Bile Acids test specific to diagnosing a Portosystemic Shunt?
NO
You run a SNAP for pancreatic lipase and it is elevated; do you consider this result definitive for the diagnosis of pancreatitis
No
Your physical examination reveals a “fluid wave”, consistent with abdominal fluid, or ascites. A sample of this fluid finds it to be a transudate. Which of the following results in a transudate
hypoalbuminemia
Physical examination reveals that Alpo is icteric (jaundice). If you could run only ONE diagnostic test to start your work-up of Alpo, it would be
Crit tube for packed cell volume and total protein
Physical examination reveals that Fred is jaundice and febrile. The minimum database is consistent with neutrophilic cholangitis. Abdominal radiographs reveal corrugated intestines and loss of serosal detail, consistent with what additional condition
pancreatitis
The 3 conditions are involved in the “Feline Triaditis”
Pancreatitis, Cholangitis, IBD
A chemistry panel reveals a significant elevation in ALP. Which other parameter is thought to be a measure of cholestatic liver disease
GGT
Hepatic lipidosis is the feline version of a K9 Reactive Hepatopathy. It represents intra-hepatic changes in metabolism secondary to a period of anorexia. The most important aspect of your treating Mouse would be
Esophageal feeding tube
What is seen in the vomiting process
Nausea/salivation
Retching (active process) +abdominal contractions
Bile (possible)
Is tenesmus seen in small or large bowel diarrhea?
Large bowel
Is increased frequency of defecation seen in small or large bowel diarrhea?
Large bowel
Is increased fecal volume typically seen in small or large bowel diarrhea?
Small bowel
Is fecal mucus seen in small or large bowel diarrhea?
Large bowel
Is melena seen in small or large bowel diarrhea?
small bowel
Is hematochezia seen in small or large bowel diarrhea?
Large bowel
Is increased urgency to defecate seen in small or large bowel diarrhea?
Large bowel
Is vomiting typically also seen in small or large bowel diarrhea
Small Bowel
Is weight loss seen in chronic small or large bowel diarrhea?
Small Bowel
Is Steatorrhea seen in small or large bowel diarrhea
Small bowel
What is steatorrhea
the excretion of abnormal quanitities of fat with the feces owing to reduced absorption of fat by the intestines
Clinical sign of small bowel diarrhea
Will you get small or large bowel diarrhea due to Trichuris vulpis infection?
Large bowel- hematechezia, weight loss, dehydration, anemia, and death
Will you get small or large bowel diarrhea with Ancylostoma caninum and Uncinaria stenocephala infection?
Small Bowel- anemia, melena, death
respiratory manifestation and interdigital dermatitis
Will you get small or large bowel diarrhea with Toxocara canis and Toxascaris leonina infection?
Small Bowel
Pot-bellied, vomiting up worms, pulmonary disease, acute death
What are the two most popular GI parasites in cats
Giardia
Tritrichomonas
What is the cause of the microcytic hypochromic, often non-regenerative anemia seen with Chronic GI bleeds?
Iron deficiency anemia
A Blood Urea Nitrogen to Creatinine ratio of _______ is consistant with a GI bleed
30
A BUN:Cr ratio of 30 is consistant with what
a gastrointestinal bleed
If a dog has hypoalbuminemia and the globulins are decreased, what is the likely cause?
GI disease, likely protein losing enteropathy
If a dog has hypoalbuminemia and the globulins are increased, what are the likely cause
1) Liver disease - lack of production
2) Kidney - loss
What is a likely cause of a hypochloremic metabolic alkalosis
-A pyloric obstruction
HCl is lost through vomiting, bicarbonate is retained leading to alkalosis
What tests are included in the Texas A&M GI panel
-Colbalamin Fasting
-Folate fasting
-TLI fasting
-Pancreatic Lipase Immunoreactivity Fasting
Where is folate absorbed?
In the proximal small intestine
What makes intrinsic factor, which is important in the uptake of cobalamin in the small intestine
Pancreas
What are your two differentials for low cobalamin
1) Distal Small Intestine problem
2) Pancreas problem (decreased intrinsic factor)
Where is cobalamin (vitamin B12) absorbed
the distal small intestine
What is the test of choice for exocrine pancreatic insufficiency (EPI)
Trypsin-like immunoreactivity (TLI)
Parasites, infectious, idiopathic, anatomic, dietary, inflammation and neoplasia are all ruleouts for what
Primary Gastrointestinal Disease
Hypoadrenoacorticism, Hyperthyroidism, Pancreatitis, Exocrine Pancreatic insufficiency, Hepatopathy, and Renal disease are all ruleouts for what
Secondary Gastrointestinal Disease
Is Boxer colitis an acute or chronic GI disturbance
Chronic
What is pseudoanorexia
anorexia caused by either dental disease, oral cavity pain, musculoskeletal disorders, routine changes, anxiety/depression, Whisker fatigue, bowel design, etc.
Primary Anorexia is consistant with what?
CNS disease causes of not eating (Hypothalmus, Anosmia, Trauma, Mass, inflammation, neoplasia)
Secondary Anorexia is consistant with what?
Diseases not in the CNS like CKD, Cholangitis, Pancreatitis, Respiratory, Infection, DKA, DM, Hyperthyroidism
What is a likely cause of gastric ulceration discovered during endoscopy
NSAID toxicity
Patients with Addisons lack what finding on a CBC?
A Stress Leukogram
(Lack of neutrophilia, Lymphopenia, Eosinopenia)
What will the basal cortisol be of a patient with Addisons disease
< 2.0 ug/dl
Patients with atypical Addisons will not have what?
Electrolyte disurbances
will only have GI signs of vomiting and diarrhea
What is the treatment for atypical Addisons
Prednisone 0.2mg/kg/day
How should you treat Granulomatous colitis of Boxer Dogs?
Enrofloxacin
How do you distinguish feline trichomoniasis from giardia in a fecal flotation
giardia moves like a fallen leaf under the microscope
What are your two differentials of a dog with diarrhea and eosinophilia
1) Parasitic infection
2) Allergies
A 2 year old male castrated german shepard presents to you with chronic small bowel diarrhea (large volume) with polyphagia and weight loss. Fecal, dewormers, antibiotics, and diet changes have all been failed treatments. What is your primary differential diagnosis? And what test should you order
Exocrine Pancreatic Insufficiency (EPI)
*Test trypsin-like immunoreactivity
What is the likely cause of an ascites that was determined to be a transudate upon aspiration?
1) Hypoalbuminemia from decreased oncotic pressure
-Renal loss
-Decreased hepatic production
-GI loss
-Severe starvation
-Third space sequestration of protein
2) Sustained portal hypertension (rare): intestinal lymph leakage and a transudate
What is the likely cause of an ascites that was determined to be a modified transudate upon aspiration (Protein 2.5-6g/dl ; Cells 500-20000)
1) Hepatic vascular congestion: causes leakage of high protein fluid from the hepatic lymph vessel.
-Right sided congestive heart failure
-Pericardial disease
-Obstruction of caudal vena cava or hepatic veins
also: Hepatic insufficiency, neoplasia, chyloperitoneum, inflammatory disease
What is the likely cause of an ascites that was determined to be an exudate upon aspiration (Protein >3.5 g/dl; Cells >5000/cmm)
1) Infectious/Inflammatory cause: Feline infectious peritonitis (FIP), Bacterial peritonitis
2) Chemical irritation: Pancreatitis, bile or urine leakage
What are your big three rule outs for a patient with protein-losing enteropathy
1) Lymphangiectasia
2) Inflammatory bowel disease
3) GI neoplasia- lymphoma
*dietary and heavy parasite burden may have some degree of PLN
*diagnose by biopsies and histopathology
What is megacolon in a cat
generalized dysfunction of the colonic smooth muscle in the cat
leads to recurrent constipation to obstipation to megacolon
poorly responsive to therapy
What are the clinical signs of megacolon in a cat
Constipation
Vomiting
Lethargy
Inappetence
Discomfort
Tenesmus
What are the steps in treating a constipated cat
1) Hydration (canned food/adding water, extra bowls, calm juice, low-sodium broth, Pedialyte, tuna juice)
2) Diet (Psyllium-enriched)
3) Laxatives
4) Prokinetics (Cisapride)
5) Treat underlying conditions
What are the effects of a congenital portosystemic shunt
1) Lead to hepatic encephalopathy
2) Develop Ammonia Biurate crystals w (PU/PD)
3) Growth abnormalities
4) Gastrointestional (Vomiting/Diarrhea)
5) Microcytosis on CBC
What are the symtpoms of hypoglycemia in dogs
Lethargy/weakness, confusion, restlessness, muscle incoordination, nervousness, trembling, seizures
What tube should you use for processing a CBC
purple top tube (EDTA)
What tube should you use for processing a chemistry panel
red top tube for blood serum
What will be seen in onion toxicity?
Heinz body anemia from oxidative injury to the RBC (hemoglobin degradation, protein oxidation, lipid peroxidation)
What 4 findings will you see from decreased metabolic function of the liver
Hypoalbuminemia
Hypocholesterolemia
Low BUN
Hypoglycemia
Ingestion of food stimulates ______________ to signal the gallbladder to release bile into the cystic duct
Cholecystokinin (CCK)
An acquired liver shunt will cause the liver to become ___________
cirrhotic - decreased function
increased bile acids will be present
What two liver enzymes signify cholestatic issues
ALP and GGT
A yellow patient that is hyperbilirubinemic with pre-hepatic causes will have______________
Low PCV/Normal TP
(e.g RBC hemolysis from IMHA)
How do you diagnose post-hepatic causes of hyperbilirubinemia like a gall ballder mucocele, extrahepatic biliary obstruction, and pancreatitis
Ultrasound
What could be the reasons for an elevated ALP in a biochemistry panel?
1) Cholestasis (GB mucocele, EHBO, Pancreatitis, Fatty liver)
2) Infection/Inflammation/Metabolic
3) Induced (Steroids, Phenobarbital, Cushings Dz)
What CBC abnormality will you see in a patient with a congenital portosystemic shunt
Microcytosis of RBC
What urinalysis findings will you see in a patient with a congenital portosystemic shunt
1) Low urine specific gravity (PU/PD)
2) Ammonium biurate crystalluria
What Chemistry abnormality will you see in a patient with a congenital portosystemic shunt
Liver is not working well
-Hypoglycemia, low BUN, hypoalbuminemia, hypocholesterolemia,
-Elevated post prandial bile acids
-Liver enzymes?
What are the symptoms of copper-associated hepatitis in dogs?
Clinical signs: Anorexia, vomiting, weight loss, jaundice, hepatic encephalopathy, ascites, PU/PD
Lab abnormalities: Increased ALT (ALP), total bilrubin, clotting times, decreased PCV, Fanconis syndrome
What dog breeds are sensitive to copper associated hepatopathy
Labrador retrievers
T/F Patients with congenital portosystemic shunts typically present icteric
False
What does oral diazepam in cats cause?
acute hepatic failure
-administer IV, orally causes absorption and travel to the liver through the vascular portal where it is metabolized to a toxic metabolite and subsequent oxidative injury due to deficiencies in glucuronidation
Is diazepam given to cats orally or IV?
IV, orally will cause oxidative injury
What can be given to treat oxidative injury in cats
S-adenosylmethionine
If you can only run one diagnostic test to workup an icteric cat, what should it be
Check PCV/TP to rule out pre-hepatic causes of hyperbilirubinemia
What are your differentials for the etiologies of hemolytic anemia in an icteric cat?
Infectious: Mycoplasma hemofelis, FIV/FeLV, FIP, dirofilariasis, Cytauxoon felis
Chemicals/Toxins: onions, acetaminophen
Hypophosphatemia: DKA treatment
Methimazole drug reaction
Lymphoma
Transfusion reactions
Neonatal isoerthyrolysis
Primary IMHA
What is the most common cause of feline cholangitis and how should you diagnose it
Neutrophilic
Do a cholecystocentesis, cytology and culture to check for bacterial infection (Ecoli, Salmonella, Klebsiella, Enterobacter, Strep, Enterococcus, Actinomyces, Pasteurella, Clostridium)
Clinical signs: lethargy, anorexia, vomiting, ptyalism, janidce, febrile, dehydrate, cranial abdominal pain
Diagnostics: ALT, GGT, > ALP, elevated total bilrubin, leukocytosis
Abdominal US: thick gallbladder wall with echogenic particulate mater. tortuous and dilated cystic and common bile ducts
What will you see upon the ultrasound of a cat with feline cholangitis
Thick gall bladder wall
Echogenic particulate matter
Tortuous and dilated cystic and common bile ducts
What liver enzymes will be elevated in feline cholangitis of neutrophilic origin
ALT and GGT > ALP
How do yo treat feline cholangitis neutrophilic (acute or chronic)
Supportive Care, Fluids, Electrolytes, Nutrition, Pain management, Vitamin K, antibiotics