SM Flashcards
Provides nutrients to the sperm
Seminal vesicle
Round ligament of the uterus is a fibrous cord that’s continuous with…
Ovarian ligament
Space with the clitoris and openings of the vagina and urethra
Vestibule
Paramesonephric duct persists as
Opening at the end of the uterine tubes
Embryonic ureter
Mesonephric duct (Wolffian duct)
Exstrophy of bladder/cloaca is caused by
Failure of mesoderm migration into cloacal membrane/ventral abdominal wall
Gartner duct cysts
Abnormal persistence of mesonephrinc duct in females
Double uterus/vagina
Results from failure of fusion of paramesonephric duct with each other or with the UG sinus
Induces Sertoli cell differentiation and male-specific vasculature
SRY
WNT4 mutation in 46 XX female
Mayer-Rokitansky-Kuster-Hauser syndrome
Sox9 suppressed and WNT4 active for
Ovarian development
Cells that make AMH
Sertoli cells
Works in paracrine fashion
Persistent mullein duct syndrome
mutations in AMH in 46 XY male
Placenta previa
Late implantation over cervical os
Accreta
Implantation on myometrium
Increta
Invasion into myometrium
Percreta
Invasion through uterine serosa into adjacent structures
3 stages of maternal response to infections of ascending infections in pregnancy
- Subchorionitis
- Chorioamnionitis
- Necrotizing amnionitis
3 stages of fetal response to infection
- Phlebitis (vein)
- Arteritis (artery)
- Necrotizing funisitis (necrosis in Wharton’s jelly)
Ascending infections of pregnancy
Mycoplasma Gardnerella Group B strep E. coli Enterococcus Candida HSV
Hematogenous infection of pregnancy
Syphilis TB Listeria CMV, Rubella Toxoplasmosis
Acute villitis
Listeria, E.coli, TB
Chronic villitis
CMV, toxoplasmosis, syphilis
Presentation of retroplacental hematoma/abruption
Painful bleeding
Virchow’s triad
Stasis
Hyper-coagulability
Vascular damage
Consequence of FVM
Fetal neurologic damages (cerebral palsy)
Monochorionic twin placenta complications
Preterm labor Twin twin transfusion Twin reversed arterial perfusion Cord entanglement Congenital malformations
P57KIP2
Differentiates complete and partial moles because it’s only expressed from maternal chromosomes
Choriocarcinoma metastasizes to where?
Lung, brain, liver
Passes through the lesser sciatic foramen
Pudenal nerve
Widest dimension of pelvis
Between arcuate lines of ilia
Narrowest dimension of pelvis
Between ischial spines
Fat filled space that allows for distention of rectum or vagina
Ischio-anal (rectal) fossa
Things that attach to the perineal body (central tendon of the perineum)
Pelvic diaphragm
Rectum
Urogenital diaphragm
Common sites for kidney stones
Renal pelvis
Common iliac vessels
Entrance to bladder
Adenomyosis
Presence of endometrial glandular tissue within myometrium.
Present with menorrhagia and dysmenorrhea with a uniformly enlarged uterus
STI that’s symptomatic in women
Chlamydia
Factors that increase risk of transmission of HIV
Hormonal effects
Nonoxynol - disrupts mucosal surface
Trauma
Microbicides
Tenofovir gel and barrier placement
HPV subtypes that cause genital warts
6, 11
HPV subtypes that cause cervical cancer
16, 18
Loose adherence of gonorrhea
Pili
Tight adherence of gonorrhea
Opa proteins
Charcot joint results from
Tabes dorsalis due to tertiary syphilis
Tx for syphilis
Penicillin
Remains unchanged during pregnancy
Gastric emptying time
Effect of pregnancy on hepatic labs
Increased D-dimer and Alk phos
Decrease albumin
Change in immune cell types during pregnancy
Increase CD8 and granulocytes
Decrease CD4 and monocytes
Fetal breathing movements begin when?
16-22 weeks
Stages of lung development
Pseudoglandular stage (5-16 weeks) Canalicular stage (16-25 weeks) Terminal sac/alveolar stage (25 weeks - 8 yrs of life)
Given to maintain PDA
Prostaglandins
Women who have delivered before have a —- during delivery
Sharper acceleration curve
4th generation of progestins and analogue of spironolactone
Drospirenone
Hepatic changes from ethinyl estradiol exposure
Decrease albumin, LDL
Increase goblins, coagulation proteins, angiotensinogen, sex hormone binding proteins, TG and HDL
Medical abortion agents
Mifepristone
Misoprostol
Contraindications to medical abortions
Ectopic pregnancy IUD Corticosteroid Hemorrhagic disease/porphyrias Anticoagulants Adrenal failure Prostaglandin allergy
Osmotic dilators
Laminaria, lamicel, dilapan
Cycle fecundability
Single menstrual cycle results in pregnancy
Cycle fecundity
Single cycle results in live birth
Iatrogenic intrauterine adhesions
Asherman’s syndrome
Causes of ovarian dysfunction
PCOS Hypothalamic amenorrhea Hyperprolactinemia Thyroid disease POI
When to check serum progesterone when assessing ovulation
day 21 of cycle
Good sperm volume
> 1.5 ml
Good sperm concentration
> 15 million/ml
Good sperm motility
> 40%
Good sperm morphology
> 4%
First line tx for ovulatory dysfunction in woman with PCOS
Letrozole
Most predictive for IVF success
Age and ovarian reserve
Connective tissue disease increases risk of what during pregnancy
Cervical insufficiency
Contraindications to cerclage in CI
Contractions/labor PPROM Infection Fetal demise Major fetal anomaly
Contraindications to expectant management
Labor
Significant vaginal bleeding
Infection
Maternal symptoms from preeclampsia
Headache
Visual changes
RUQ pain
Used to prevent eclampsia
MgSO4
Presentation of spontaneous abortion
Vaginal bleeding
Pelvic pain
Incidental finding on US
What should you absolutely screen women for that are going through menopause?
Depression!
FDA approved SSRI for VMS
Paroxetene
What menopausal symptoms don’t resolve without treatment
Local vuvlovaginal symptoms
What layer is missing from the uterine tube?
Submucosa
Cervical glands
Branched and often with cysts
Estrogen effects on breast tissue
Elaboration of glands and ducts
Progesterone effects on breast tissue
Dilated ducts with milk
Placenta previa
No pain
Fetal heart rate monitoring normal
Vasa previa
Active, heavy bright red bleeding compromising fetus
Fetal heart rate monitoring abnormal
Causes nausea and vomiting of pregnancy
HCG
Causes GERD, constipation, decreased gallbladder motility of pregnancy
Progesterone
Etiology for anovulation
PCOS Hypothalamic amenorrhea Hyperprolactinemia Thyroid disease Premature ovarian failure
For women age 40-45 with irregular menstrual cycles, exclude
pregnancy, hyperprolactinemia and thyroid dysfunction
Estrogen only therapy leads to an increase risk of what?
Endometrial cancer`
Rapid plasma reagin
Test used for syphilis prior to to dark field microscopy
NE acting on —- receptor contracts bladder neck
Alpha 1 receptors
NE acting on —- receptor relaxes detrusor muscle
B3 receptor
ACh acting on — receptor contracts detrusor muscle
M3 receptor
Stress incontinence
Lost of tone in UG diaphragm and increased intra-abdominal pressure
Highest control of micturition
Periaqueductal grey (PAG)
L Region of brainstem
Controls striated muscles to promote urinary continence
AKA - Pontine Storage Center
M Region of brainstem
Controls smooth muscle to promote urination
AKA - Pontine Micturition Center
Why does a UTI lead to urinary frequency?
Afferent sensory nerves are hyper sensitized which leads to a lower threshold for bladder contractions.
What nervous system is needed for defection but not urination.
Enteric nervous system
Ex: Hirschsprung’s disease -> megacolon
Example of conditions that can damage NANC nerve terminal and result in the absence of male erection in the presences of viagra
Diabetes
CV disedase
Orgasm
Rhythmic contractions of perineal muscles
Pudenal nerve activated globally
Neuropeptides of LSt (lumbar sphinothalamic) nerves
Galanin, CCK, enkephalin, NK-1R
Sexually dimorphic nuclei in the hypothalamus located in the medial prepotic area
Bigger in males
Lesion in SDN in males
Problems with sexual function and motivation
Lesion in SDN in females
Problems with mate selection
Inhibits sexual function
Ventral medullary regions of brainstem
Trisomy 21 maternal serum findings
Decreased AFP, uE3
Increased hCG, inhibin A
Large nuchal translucency
Down’s Syndrome
Measured for open neural tube defects
AFP and acetylcholinesterase
Confined placental mosaicism is associated with
IUGR
Growth and density of amniotic fluid cells is ideal at
16-18 weeks gestation
Maternal age increases risk for autosomal aneuploidies and sex chromosome aneuploidies except
45, X Turner’s syndrome
Polyploidies or micro deletions
Increase risk of translocation Down’s syndrome if
Mom is carrying the robertsonian translocation
When is maternal serum screening less effective
Twin gestations
Younger maternal age groups due to lower PPV
Carrier detection African American
Hemoglobinopathies, Hgb S, C
Carrier detection Mediterranean
Beta-thalassemia
Carrier detection SE Asian
Alpha-thalassemia