Slides

Question 1

Answer 1

Target Cell; Seen in HbC disease, Asplenia, Liver Disease and alcoholism (Nonmegaloblastic anemia), Thalassemias (HALT).

Question 2

Answer 2

Dacrocytes (“Teardrop Cells”); Bone marrow infiltration (e.g., Myelofibrosis), Thalassemias.

Question 3

Answer 3

Basophilic Stippling; Sideroblastic Anemia, Thalassemias.

Question 4

Answer 4

Ringed Sideroblasts; Sideroblastic Anemias in bone marrow.

Question 5

Answer 5

Hypersegmented Neutrophil; Megaloblastic Anemia.

Question 6

Answer 6

Aplastic Anemia; Hypocellular bone marrow with fatty infiltration (dry bone marrow tap).

Question 7

Answer 7

Echinocyte (“Burr cell”); Liver disease, ESRD, Pyruvate kinase deficiency

Question 8

Answer 8

Spherocytes; Hereditary Spherocytosis, Autoimmune (Drug and infection induced) hemolytic Anemia.

Question 9

Answer 9

Elliptocyte; Hereditary Elliptocytosis.

Question 10

Answer 10

Sickle Cell; Sickle Cell Anemia.

Question 11

Answer 11

Howell-Jolly Bodies (and sickle cells); Function Hyposplenia (Sickle cell disease), Asplenia.

Question 12

Answer 12

Bite Cells; G6PD deficiency.

Question 13

Answer 13

Heinz Bodies; G6PD deficiency.

Question 14

Answer 14

Schistocytes (“Helmet Cells”); Microangiopathic hemolytic anemia (e.g., DIC, TTP/HUS, HELLP syndrome), Mechanical hemolysis (e.g., Heart valve prosthesis).

Question 15

Answer 15

Neutrophil; Neutrophilia seen in Bacterial infections (e.g., appendicitis), Tissue necrosis (e.g., MI); Neutropenia seen in Sepsis/postinfection, drugs (including chemotherapy), aplastic anemia, SLE, radiation.

Question 16

Answer 16

Monocyte; Monocytosis seen in chronic inflammatory states (e.g., autoimmune and infectious) and malignancy.

Question 17

Answer 17

Macrophage

Question 18

Answer 18

Eosinophil; Eosinophilia is seen in PACCMAN; Eosinopenia is seen in Cushing syndrome and corticosteroids.

Question 19

Answer 19

Basophils; Basophilia seen in Chronic myeloproliferative disorders (e.g., CML, Polycythemia vera).

Question 20

Answer 20

Lymphocyte; Lymphocytosis seen in viral infection and bordetella pertusis (Whooping cough) infection; Lymphopenia seen in HIV, Digeorge syndrome, SCID, SLE, Corticosteroids, radiation, sepsis, postoperative.

Question 21

Answer 21

Plasma cell

Question 22

Answer 22

Leukoerythroblastic reaction; Immature bone marrow WBCs and nucleated RBCs in the peripheral blood.

Question 23

Answer 23

Atypical lymphocyte; Infectious mononucleosis, CMV.

Question 24

Answer 24

Toxic granulation and Dohle bodies; Infection, Leukemoid reaction.

Question 25

Answer 25

Myelofibrosis; Also shows teardrop RBCs and nucleated RBCs.

Question 26

Answer 26

Auer rods; Acute promyelocytic leukemia (AML).

Question 27

Answer 27

Blast cell

Question 28

Answer 28

Smudge cells; Chronic lymphocytic leukemia.

Question 29

Answer 29

Hairy cell Leukemia

Question 30

Answer 30

Normal lymph node; B cells - Geminal follicle; T cells - Paracortex; Histiocytes - Sinus.

Question 31

Answer 31

Burkitt Lymphoma; “Starry sky” appearance (Neoplastic B cells - dark night; Reactive histiocytes with phagocytic debris - stars).

Question 32

Answer 32

Follicular hyperplasia –> Follicular lymphoma.

Question 33

Answer 33

Classic Reed-Sterberg cell; Hodgkin Lymphoma.

Question 34

Answer 34

Nonclassic Reed-Sterberg cell; Nodular sclerosing hodgkin lymphoma (RS cell in clear lake-like spaces - Lacunar cell).

Question 35

Answer 35

Birbeck (“Tennis racket”) granules in Langerhans cell.

Question 36

Answer 36

Rouleaux formation of RBCs on blood smear; Multiple myeloma.