Slides

Question 1

What is this and why?

Answer 1

Minimal Change Disease - podocyte foot process effacement

Question 2

What is this and why?

Answer 2

FSGS because only part of the glomeruli is carred, and only some glomeruli are effected

Question 3

What is this and why?

Answer 3

This is a comparison of normal glomeruli and podocyte foot process effacement in MCD and FSGS

Question 4

What is this and why?

Answer 4

These are wire loop capillaries that correspond to Membranous Nephropathy

Question 5

What is this and why?

Answer 5

Membranous Nephropathy with granular IgG deposits

Question 6

What is this and why?

Answer 6

Membranous Nephropathy due to the spikes and domes in the glomerular basement membrane

Question 7

What is this and why?

Answer 7

MPGN due to increased cellularity and pronounced “lobularity”

Question 8

What is this and why?

Answer 8

MPGN, due to increased cellularity and lobulation

Question 9

How could MPGN Type I and Type II be differentiated?

Answer 9

On the slide alone, you can’t tell - need a stem for IgG + C3 staining (Type I) or C3 (Type II)

Question 10

What is this and why?

Answer 10

Diabetic Nephropathy, due to the Kimmelstein Wilson lesions in the big pink blob

Question 11

What is this and why?

Answer 11

Chronic Glomerulonephritis; because there’s a bunch of totally sclerosed Glomeruli

Question 12

What is this and why?

Answer 12

Post Steptococcal Glomerulonephritis - Starry Sky fluorescnece

Question 13

What is this and why?

Answer 13

Post Streptococcal Glomerulonephritis, due to subepithelial humps

Question 14

What is this and why?

Answer 14

Rapidly Progressive Glomerulonephritis on Light Microscopy, due to proliferation of cells, possibly a result of Type I (Anti-GBM/Goodpasture’s) or Type II (Lupus Nephritis) or Type III (MPA/GPA/EGPA)

Question 15

What type of RPGN is this and why?

Answer 15

Type I RPGN due to the linear deposits, suggesting anti-GBM disease

Question 16

What type of RPGN is this and why?

Answer 16

RPGN Type II, due to the granular IgG deposits which suggests an immune complex disease like SLE or PSGN with C3 and IgG/A

Question 17

What type of RPGN is this and why?

Answer 17

This is RPGN Type III, which has no findings on FM or EM but shows up as hypercellularity on LM, due to the thickening of the fibrinoid vessel, suggesting MPA

Question 18

What type of RPGN is this and why?

Answer 18

This is RPGN Type III, which has no findings on FM or EM but shows up as hypercellularity on LM, due to the thickening of the fibrinoid vessel, suggesting GPA because it is in a glomeruli

Question 19

What is this and why?

Answer 19

This is IgA nephropathy, since the mesangial tree of the Glomeruli has thickened due to deposition of IgA immune complexes

Question 20

What is this and why?

Answer 20

IgA Nephropathy due to granular deposition of IgA immune complexes

Question 21

What is this and why?

Answer 21

Amyloidosis, due to the Congo Red stain showing apple-green birefringence on polarized light